Methoxamine Hydrochloride - CAS 61-16-5
Catalog number: 61-16-5
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C11H18ClNO3
Molecular Weight:
247.72
COA:
Inquire
Targets:
Adrenergic Receptor
Description:
Methoxamine Hydrochloride is an alpha-1 adrenergic agonist, similar in structure to butaxamine and 2,5-DMA. It causes prolonged peripheral vasoconstriction. It induces vasoconstriction of skin and splanchnic blood vessels, thus increasing peripheral vascular resistance and raising mean arterial blood pressure. lt is used for the treatment of paroxysmal supraventricular tachycardia and is used as a booster in the state of low blood pressure. It has been listed.
Publictions citing BOC Sciences Products
  • >> More
Purity:
98%
Appearance:
Solid powder
Synonyms:
1-(2,5-Dimethoxyphenyl)-2-aminopropanol;2-Amino-1-(2,5-dimethoxyphenyl)-1-propanolhydrochloride;Alpha-(1-aminoethyl)-2,5-dimethoxy-benzenemethano hydrochloride;Methoxamine HCl;Vasoxyl hydrochloride;2-Amino-1-(2,5-dimethoxyphenyl)propan-1-ol hydrochloride
Solubility:
Soluble in DMSO, not in water
Storage:
2-8°C
MSDS:
Inquire
Application:
Methoxamine Hydrochloride is used for the treatment of paroxysmal supraventricular tachycardia and is used as a booster in the state of low blood pressure.
Quality Standard:
In-house standard
Quantity:
Kilograms to Tons
Boiling Point:
368.4 °C at 760 mmHg
Melting Point:
212-216 °C
InChIKey:
YGRFXPCHZBRUKP-UHFFFAOYSA-N
InChI:
InChI=1S/C11H17NO3.ClH/c1-7(12)11(13)9-6-8(14-2)4-5-10(9)15-3;/h4-7,11,13H,12H2,1-3H3;1H
Canonical SMILES:
CC(C(C1=C(C=CC(=C1)OC)OC)O)N.Cl
Current Developer:
Methoxamine Hydrochloride has been listed.
1.Stimulation of calcium-sensing receptors induces endothelium-dependent vasorelaxations via nitric oxide production and activation of IKCa channels.
Greenberg HZ1, Shi J2, Jahan KS2, Martinucci MC2, Gilbert SJ2, Vanessa Ho WS2, Albert AP2. Vascul Pharmacol. 2016 May;80:75-84. doi: 10.1016/j.vph.2016.01.001. Epub 2016 Jan 6.
Stimulation of vascular calcium-sensing receptors (CaSRs) is reported to induce both constrictions and relaxations. However, cellular mechanisms involved in these responses remain unclear. The present study investigates the effect of stimulating CaSRs on vascular contractility and focuses on the role of the endothelium, nitric oxide (NO) and K(+) channels in these responses. In wire myography studies, increasing [Ca(2+)]o from 1mM to 6mM induced concentration-dependent relaxations of methoxamine pre-contracted rabbit mesenteric arteries. [Ca(2+)]o-induced relaxations were dependent on a functional endothelium, and were inhibited by the negative allosteric CaSR modulator Calhex-231. [Ca(2+)]o-induced relaxations were reduced by inhibitors of endothelial NO synthase, guanylate cyclase, and protein kinase G. CaSR activation also induced NO production in freshly isolated endothelial cells (ECs) in experiments using the fluorescent NO indicator DAF-FM.
2.Effects of tempol on altered metabolism and renal vascular responsiveness in fructose-fed rats.
Abdulla MH1, Sattar MA2, Johns EJ1. Appl Physiol Nutr Metab. 2016 Feb;41(2):210-8. doi: 10.1139/apnm-2015-0411. Epub 2015 Nov 5.
This study investigated the effect of tempol (a superoxide dismutase mimetic) on renal vasoconstrictor responses to angiotensin II (Ang II) and adrenergic agonists in fructose-fed Sprague-Dawley rats (a model of metabolic syndrome). Rats were fed 20% fructose in drinking water (F) for 8 weeks. One fructose-fed group received tempol (FT) at 1 mmol·L(-1) in drinking water for 8 weeks or as an infusion (1.5 mg·kg(-1)·min(-1)) intrarenally. At the end of the treatment regimen, the renal responses to noradrenaline, phenylephrine, methoxamine, and Ang II were determined. F rats exhibited hyperinsulinemia, hyperuricemia, hypertriglyceridemia, and hypertension. Tempol reduced blood glucose and insulin levels (all p < 0.05) in FT rats compared with their untreated counterparts. The vasoconstriction response to all agonists was lower in F rats than in control rats by about 35%-65% (all p < 0.05). Vasoconstrictor responses to noradrenaline, phenylephrine, and methoxamine but not Ang II were about 41%-75% higher in FT rats compared with F rats (all p < 0.
3.Pharmacological evidence that NaHS inhibits the vasopressor responses induced by stimulation of the preganglionic sympathetic outflow in pithed rats.
Centurión D1, De la Cruz SH2, Gutiérrez-Lara EJ2, Beltrán-Ornelas JH2, Sánchez-López A2. Eur J Pharmacol. 2016 Jan 5;770:40-5. doi: 10.1016/j.ejphar.2015.11.057. Epub 2015 Nov 28.
It has been reported that i.v. administration of NaHS, a donor of H2S, elicited dose-dependent hypotension although the mechanisms are not completely understood. In this regard, several mechanisms could be involved including the inhibition of the vasopressor sympathetic outflow. Thus, this study was designed to determine the potential capability of NaHS to mediate inhibition of the vasopressor responses induced by preganglionic sympathetic stimulation. For this purpose, Wistar rats were anaesthetised, pithed and cannulated for drug administration. In animals pre-treated with gallamine, the effect of i.v. infusion of NaHS (310 and 560μg/kgmin) or its vehicle (phosphate buffer) was determined on the vasopressor responses induced by: (1) sympathetic stimulation (0.03-10Hz); (2) i.v. bolus injections of exogenous noradrenaline (0.03-3μg/kg); or (3) methoxamine (1-100μg/kg). The vasopressor responses induced by preganglionic sympathetic stimulation were dose-dependently inhibited by i.
4.Endothelial nitric oxide weakens arterial contractile responses and reduces blood pressure during early postnatal development in rats.
Sofronova SI1, Borzykh AA2, Gaynullina DK3, Kuzmin IV4, Shvetsova AA4, Lukoshkova EV5, Tarasova OS4. Nitric Oxide. 2016 Feb 23;55-56:1-9. doi: 10.1016/j.niox.2016.02.005. [Epub ahead of print]
OBJECTIVE: During maturation the vascular system undergoes structural and functional remodeling. At the systemic level it results in a gradual increase of arterial blood pressure during postnatal ontogenesis. The mechanisms of maintaining the blood pressure at a comparatively low level during the early postnatal development are not completely understood. Recently we showed that the hindlimb arteries of young (1-2 wk-old) rats exhibited an enhanced endothelial NO-pathway activity, which weakened their contractile responsiveness compared to the arteries of adult rats. Here we tested the hypothesis that an increased tonic endothelial NO production can take place in the whole vascular system leading to a decreased level of systemic blood pressure in young rats.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Adrenergic Receptor Products


CAS 94-07-5 Synephrine

Synephrine
(CAS: 94-07-5)

Synephrine is an α-adrenergic receptor agonist used as a vasoconstrictor.

CAS 847829-38-3 Rezatomidine

Rezatomidine
(CAS: 847829-38-3)

Rezatomidine is a selective α2-adrenoreceptor antagonist under the development of Allergan. No recent development was reported for the treatment of Diabetic neu...

Moxonidine hydrochloride
(CAS: 75536-04-8)

Moxonidine hydrochloride is a mixed agonist of α2-adrenergic receptor (α2AR) and imidazoline-1 receptor(I1R). Its Ki values is 4.2±3.2 nmol/L, 13.0±4.2 nmol/L, ...

CL-316243
(CAS: 183720-02-7)

CL-316243 is a potent and highly selective β3-adrenoceptor agonist (EC50 = 3 nM) with > 10000-fold selective over β1 and β2 receptors. CL 316243 possesses anti-...

CAS 61-76-7 Phenylephrine HCl

Phenylephrine HCl
(CAS: 61-76-7)

Phenylephrine HCl is a selective α1-adrenergic receptor agonist of the phenethylamine class used primarily as a decongestant, as an agent to dilate the pupil, a...

CAS 29122-68-7 Atenolol

Atenolol
(CAS: 29122-68-7)

Atenolol, with antianginal and antiarrhythmic properties, it is a cardioselective beta-adrenergic blocker and used in hypertension control.

CAS 54239-39-3 Cimbuterol

Cimbuterol
(CAS: 54239-39-3)

Cimbuterol is a β-adrenergic agonist.

Batefenterol
(CAS: 743461-65-6)

Batefenterol is a Beta 2 adrenergic receptor agonist and also a Muscarinic receptor antagonist. It shows high affinity for hM2 (Ki = 1.4 nM), hM3 muscarinic rec...

CAS 149247-12-1 QF0301B

QF0301B
(CAS: 149247-12-1)

QF0301B is an α1 adrenergic receptor antagonist and shows noncompetitive low action in 5-HT3, muscarinic and nicotinic receptors, or as Ca2+ antagonist.

CAS 6211-32-1 Rauwolscine hydrochloride

Rauwolscine hydrochloride
(CAS: 6211-32-1)

Rauwolscine hydrochloride is the hydrochloride salt of Rauwolscine which is a potent, reversible and specific α2 adrenergic receptor antagonist with a Ki values...

CAS 119942-70-0 MK-912 hydrochloride

MK-912 hydrochloride
(CAS: 119942-70-0)

MK-912 is a potent new selective alpha 2-adrenergic receptor antagonist that is originated by Merck & Co for the treatment of Major depressive disorder. In Dec ...

CAS 118457-14-0 L-nebivolol

L-nebivolol
(CAS: 118457-14-0)

Nebivolol, a highly selective β1-adrenergic receptor inhibitor, has vasodilatory effect so that could be effective against hypertension. It was just withdrawed ...

CAS 29110-48-3 Guanfacine HCl

Guanfacine HCl
(CAS: 29110-48-3)

Guanfacine HCl is the hydrochloride salt of Guanfacine. Guanfacine, a selective agonist of α2A receptor, is a sympatholytic drug to treat attention deficit hype...

CAS 498-45-3 Scopine

Scopine
(CAS: 498-45-3)

Scopine is the metabolite of anisodine, which is a α1-adrenergic receptor agonist and used in the treatment of acute circulatory shock.

CAS 51322-75-9 Tizanidine

Tizanidine
(CAS: 51322-75-9)

Tizanidine, a short-acting drug, is an agonist at a2-adrenergic receptor reducing spasticity by increasing presynaptic inhibition of motor neurons.

Milveterol
(CAS: 652990-07-3)

Milveterol is a long-acting β(2)-adrenoceptor agonist. It is potentially useful for the treatment of chronic obstructive pulmonary disease (COPD) and asthma. It...

CAS 56-47-3 Deoxycorticosterone acetate

Deoxycorticosterone acetate
(CAS: 56-47-3)

Deoxycorticosterone acetate is a steroid hormone used for intramuscular injection for replacement therapy of the adrenocortical steroid.

MK-0634
(CAS: 211031-01-5)

MK-0634, also called as L-796568, is an β3 adrenergic receptor agonist that was progressed into clinical studies for the treatment of obesity in the early 2000s...

CAS 89365-50-4 Salmeterol

Salmeterol
(CAS: 89365-50-4)

Salmeterol is a long-acting beta2-adrenergic receptor (beta 2AR) agonist. It is used clinically in the maintenance and prevention of asthma symptoms and mainten...

CAS 66711-21-5 Apraclonidine

Apraclonidine
(CAS: 66711-21-5)

Apraclonidine is a clonidine derivative with relatively selective alpha-2-adrenergic agonistic activity. It is an α2 adrenergic receptor agonist and a weak α1 a...

Chemical Structure

CAS 61-16-5 Methoxamine Hydrochloride

Quick Inquiry

Verification code

Featured Items