Methotrexate - CAS 59-05-2
Not Intended for Therapeutic Use. For research use only.
Category:
ADCs
Product Name:
Methotrexate
Catalog Number:
59-05-2
Synonyms:
WR19039; CL14377
CAS Number:
59-05-2
Description:
Methotrexate(WR19039; CL14377) can interfere with the growth of certain cells of the body, especially cells that reproduce quickly, such as cancer cells, bone marrow cells, and skin cells.
Molecular Weight:
454.44
Molecular Formula:
C20H22N8O5
COA:
Inquire
MSDS:
Inquire
Tag:
ADCs Cytotoxin
Chemical Structure
CAS 59-05-2 Methotrexate

Related ADCs Cytotoxin Products


CAS 5489-15-6 O-Methylisocorydine Iodomethylate

O-Methylisocorydine Iodomethylate
(CAS: 5489-15-6)

Aporphin alkaloid derivative of Isocorydine from plants of the Corydalis genus, Fumariaceae, a long-lasting ganglioblocker, with a sympathetic/parasympathetic a...

CAS 477-30-5 Colcemide

Colcemide
(CAS: 477-30-5)

An antineoplastic alkaloid from Colchicum autumnale L. isolated from Colchicum autumnale L.

Glutasam
(CAS: 148822-98-4)

Complex of lanthanide element,an anticoagulant. The lanthanide element from Glutasam replaces calcium in its complex with prothrombine, thus preventing the form...

CAS 36101-54-9 Peganole

Peganole
(CAS: 36101-54-9)

Derivative of Desoxypeganine from plants of the Zygophyllaceae family, a psychotomimetic agent on dogs and cats; acetylcholinesterase inhibitor.

CAS 994-29-6 Et3N-Me

Et3N-Me
(CAS: 994-29-6)

Ganglioblocker Quaternary triethylamine derivative Synthetic

CAS 6659-51-4 Quireston

Quireston
(CAS: 6659-51-4)

Synthetic, a potent inhibitor of high-affinity choline uptake (HAChU) in synaptosomes.

Pempidine hydriodide
(CAS: 4167-76-7)

Synthetic, a neuronal nicotinic AChR antagonist.

CAS 41451-87-0 Turkesterone

Turkesterone
(CAS: 41451-87-0)

Turkesterone is a phytoecdysteroid possessing an 11alpha-hydroxyl group, also is an analogue of the insect steroid hormone 20-hydroxyecdysone.

CAS 485-49-4 (+)-Bicuculline

(+)-Bicuculline
(CAS: 485-49-4)

Ionotropic GABAA receptors are ligand-gated ion channels that facilitate the passing of chloride ions across the cell membrane and promote an inhibitory influen...

CAS 51052-72-3 Isobicyphat

Isobicyphat
(CAS: 51052-72-3)

Synthetic organophosphorous compound, a non-competitive GABA antagonist; potent convulsant: causes epileptoform seizures.

CAS 205304-86-5 Tubulysin A

Tubulysin A
(CAS: 205304-86-5)

Tubulysin A is a novel antibiotic, which is anti-microtubule, anti-mitotic, apoptosis inducer, anticancer, anti-angiogenic, and antiproliferative. Tubulysins sh...

Seco-DuocarmycinCN
(CAS: 1613286-54-6)

Seco-Duocarmycin CN is a cytotoxic agent, used as the cytotoxic component in antibody-drug conjugates.

CAS 224790-71-0 Etbicythionat

Etbicythionat
(CAS: 224790-71-0)

GABA receptor antagonist

CAS 145017-83-0 ω-agatoxin-IVA

ω-agatoxin-IVA
(CAS: 145017-83-0)

ω-agatoxin-IVA (ω-AGA IVA) is a peptide originally isolated from funnel web-spider venom Agelenopsis aperta. This peptide is a specific blocker of P/Q-type calc...

3-alpha-iodo-Imperialine

A cardioselective M2-cholinoblocking compound semi-synthetic derivative of Imperialine alkaloid Derived from base alkaloid Imperialine, isolated from the plant ...

Ungerine Nitrate

Alkaloid , from plants of the Ungernia genus, Amaryllidaceae.

CAS 145199-73-1 Kaliotoxin

Kaliotoxin
(CAS: 145199-73-1)

Potent blocker of voltage-sensitive K+ channels (IC50 values are 0.1, 1.1 and 25 nM for KV1.3, KV1.1 and KV1.2 channels) respectively). Also inhibits Ca2+-activ...

Convolvidine
(CAS: 50656-81-0)

A native alkaloid A tropane alkaloid Extracted from Convolvulus subhirsitus plant.

PBD dimer
(CAS: 1222490-34-7)

PBD dimer is a cytotoxic agent, used as the cytotoxic component in antibody-drug conjugates.

Q Pr-i
(CAS: 45842-68-0)

Synthetic, nicotinic AChR. Rigid bicyclic analog of TMA and TEA.

Reference Reading


1. An algorithm to determine the mechanism of drug distribution in lipid-core nanocapsule formulations
Catiuscia P. Oliveira, Cristina G. Venturini, Adriana R. Pohlmann*. Soft Matter, 2013, 9, 1141–115
Indomethacin, diclofenac (acid) and indomethacin ethyl ester showed low solubility in water, with log D values higher than 2. The formulations were then prepared using drug concentrations higher than their saturation concentration in the aqueous phase. The log D value for indomethacin was similar to that determined for methotrexate ethyl ester, but IndOH-LNC1 and MTX(OEt)2-LNC0.5 were classified as having different types of distribution. On the other hand, the water solubilities of these drugs are slightly different (higher for methotrexate diethyl ester), while those of diclofenac (acid) and methotrexate diethyl ester are similar. Therefore, neither the log D nor the water solubility values can be used exclusively to explain the results. The difference between the distribution of methotrexate diethyl ester and those of indomethacin and diclofenac lies in the chemical nature of the functional groups, which are amines (ammonium) in the former and carboxylic (carboxylate) for the latter two cases. Thus, the results suggested that the drug interacts with PCL by hydrogen bonding, the O–H/O (indomethacin and diclofenac with PCL) interaction being stronger than N–H/O (methotrexate diethyl ester with PCL).
2. Gadolinium texaphyrin–methotrexate conjugates. Towards improved cancer chemotherapeutic agents
Wen-Hao Wei, Mark Fountain, Darren Magda*, Jonathan L. Sessler*. Org. Biomol. Chem. , 2005, 3 , 3290–3296
Therefore, in an effort to reduce non-tumor cell toxicity, chemotherapeutic agents better able to localize to tumors, either intrinsically or via attachment to tumor-directing carriers, are being developed. The latter species, often referred to as conjugates, show particular promise and have been shown to increase efficacy or decrease toxicity to non-tumor tissues in several cases. In this work we report the synthesis of conjugates of motexafin gadolinium, an experimental drug demonstrating significant tumor targeting, with methotrexate, a DNA synthesis inhibitor. The resulting conjugates, containing either ester or amide linkers, were tested in vitro for anti-proliferative activity using A549 lung cancer cells. Under conditions involving limited drug exposure times, the ester conjugate exhibited greater activity than the corresponding amide conjugate or methotrexate alone.
3. Direct measurement of drug–enzyme interactions by atomic force microscopy; dihydrofolate reductase and methotrexate
Shellie M. Rigby-Singleton, Stephanie Allen, Saul J. B. Tendler*. J. Chem. Soc., Perkin Trans. 2, 2002, 1722–1727
High-resolution crystal structures of the enzyme–inhibitor complex have also been elucidated. In particular, the inhibitor methotrexate (MTX) has been studied extensively over the last half century . Methotrexate upon binding to DHFR inhabits the same hydrophobic binding site as folate. Demonstrating a higher binding affinity for DHFR than folate, methotrexate acts as a competitive inhibitor of DHFR. When bound, methotrexate adopts an inverse orientation comparedto that of folate, but retains the same hydrogen bonding geometry as the enzyme–substrate complex. The binding site is configured of the αB helix connecting the αC helix (43–48,lc) to the βC sheet (58–62,lc), and a 9 to 23,lc residue loop (connecting the βA sheet and the αB helix).
4. Chromatic response of polydiacetylene vesicle induced by the permeation of methotrexate
Min Jae Shin, Ye Jin Kim and Jong-Duk Kim*. Soft Matter, 2015, 11, 5037—5043
In this study, a mixed vesicle of AEPCDA stabilized by vesicleforming surfactant, dimethyldioctadecylammonium chloride (DODAC) was fabricated as a model chromatic polydiacetylene layer, and methotrexate was used as a target material.We employed two types of detecting system in this study. One of the systems involved a simple detection of methotrexate on the exterior by the vesicle solution, whereas the other system involved detection of methotrexate inside the vesicle solution. In the second method, when methotrexate from the interior permeates out of the vesicle, the color of the vesicle can be changed. Fig. 1 shows a schematic color shift of the mixed vesicle during the permeation of methotrexate. This color shift of polydiacetylene layer can be used for the detection of the target material by both adsorption from the outside and permeation from the inside of the vesicle.