Methoprene - CAS 40596-69-8
Catalog number: 40596-69-8
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C19H34O3
Molecular Weight:
310.47
COA:
Inquire
Targets:
Antiparasitic
Description:
Methoprene, is a juvenile hormone (JH) analog which can be used as an a biological pesticide.
Publictions citing BOC Sciences Products
  • >> More
Purity:
≥95%
Appearance:
White solid
Synonyms:
propan-2-yl (2E,4E)-11-methoxy-3,7,11-trimethyldodeca-2,4-dienoate; (2E,4E)-11-Methoxy-3,7,11-trimethyl-2,4-Dodecadienoic Acid 1-Methylethyl Ester;
Solubility:
Soluble in DMSO
Storage:
Store at 2-8 °C
MSDS:
Inquire
Application:
A biological pesticide
Quality Standard:
Enterprise Standard
Shelf Life:
As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly
Quantity:
Grams-Kilos
Density:
0.9261
InChIKey:
NFGXHKASABOEEW-LDRANXPESA-N
InChI:
1S/C19H34O3/c1-15(2)22-18(20)14-17(4)11-8-10-16(3)12-9-13-19(5,6)21-7/h8,11,14-16H,9-10,12-13H2,1-7H3/b11-8+,17-14+
Canonical SMILES:
CC(C)OC(=O)C=C(C)C=CCC(C)CCCC(C)(C)OC
1.Differential Juvenile Hormone Variations in Scale Insect Extreme Sexual Dimorphism.
Vea IM1, Tanaka S1, Shiotsuki T2, Jouraku A2, Tanaka T1, Minakuchi C1. PLoS One. 2016 Feb 19;11(2):e0149459. doi: 10.1371/journal.pone.0149459. eCollection 2016.
Scale insects have evolved extreme sexual dimorphism, as demonstrated by sedentary juvenile-like females and ephemeral winged males. This dimorphism is established during the post-embryonic development; however, the underlying regulatory mechanisms have not yet been examined. We herein assessed the role of juvenile hormone (JH) on the diverging developmental pathways occurring in the male and female Japanese mealybug Planococcus kraunhiae (Kuwana). We provide, for the first time, detailed gene expression profiles related to JH signaling in scale insects. Prior to adult emergence, the transcript levels of JH acid O-methyltransferase, encoding a rate-limiting enzyme in JH biosynthesis, were higher in males than in females, suggesting that JH levels are higher in males. Furthermore, male quiescent pupal-like stages were associated with higher transcript levels of the JH receptor gene, Methoprene-tolerant and its co-activator taiman, as well as the JH early-response genes, Krüppel homolog 1 and broad.
2.Synergism of the IGRs Methoprene and Pyriproxyfen Against Larval Cat Fleas (Siphonaptera: Pulicidae).
Rust MK1, Lance W, Hemsarth H2. J Med Entomol. 2016 Mar 8. pii: tjw010. [Epub ahead of print]
Insect growth regulators (IGRs) methoprene and pyriproxyfen are widely used as topical treatments to pets or applied to the indoor environment to control cat fleas, Ctenocephalides felis (Bouché). The toxicity of methoprene, pyriproxyfen, and combinations of both IGRs to cat flea larvae was determined. The LC50 of methoprene and pyriproxyfen applied to larval rearing medium was 0.39 and 0.19 ppm, respectively. Combinations of methoprene:pyriproxyfen in ratios of 1:1, 5:1, 10:1, and 20:1 produced LC50s of 0.06, 0.09, 0.19, and 0.13 ppm, respectively. The pyriproxyfen synergized the activity of methoprene as indicated by the combination indices (CI). The ratio of methoprene:pyriproxyfen (40:1) provided an LC50 of 0.42 ppm and the pyriproxyfen was not synergistic. Combinations of pyriproxyfen:methoprene in ratios of 5:1, 10:1, and 20:1 provided LC50s of 0.14, 0.20, 0.20 ppm, respectively, and the methoprene did not synergize the activity of pyriproxyfen.
3.TOR Pathway-Mediated Juvenile Hormone Synthesis Regulates Nutrient-Dependent Female Reproduction in Nilaparvata lugens (Stål).
Lu K1,2, Chen X3, Liu WT4, Zhou Q5. Int J Mol Sci. 2016 Mar 28;17(4). pii: E438. doi: 10.3390/ijms17040438.
The "target of rapamycin" (TOR) nutritional signaling pathway and juvenile hormone (JH) regulation of vitellogenesis has been known for a long time. However, the interplay between these two pathways regulating vitellogenin (Vg) expression remains obscure. Here, we first demonstrated the key role of amino acids (AAs) in activation of Vg synthesis and egg development in Nilaparvata lugens using chemically defined artificial diets. AAs induced the expression of TOR and S6K (S6 kinase), whereas RNAi-mediated silencing of these two TOR pathway genes and rapamycin application strongly inhibited the AAs-induced Vg synthesis. Furthermore, knockdown of Rheb (Ras homologue enriched in brain), TOR, S6K and application of rapamycin resulted in a dramatic reduction in the mRNA levels of jmtN (juvenile hormone acid methyltransferase, JHAMT). Application of JH III on the RNAi (Rheb and TOR) and rapamycin-treated females partially rescued the Vg expression.
4.Effects of juvenile hormone (JH) analog insecticides on larval development and JH esterase activity in two spodopterans.
El-Sheikh el-SA1, Kamita SG2, Hammock BD3. Pestic Biochem Physiol. 2016 Mar;128:30-6. doi: 10.1016/j.pestbp.2015.10.008. Epub 2015 Oct 22.
Juvenile hormone analog (JHA) insecticides are biological and structural mimics of JH, a key insect developmental hormone. Toxic and anti-developmental effects of the JHA insecticides methoprene, fenoxycarb, and pyriproxyfen were investigated on the larval and pupal stages of Spodoptera littoralis and Spodoptera frugiperda. Bioassays showed that fenoxycarb has the highest toxicity and fastest speed of kill in 2nd instar S. littoralis. All three JHAs affected the development of 6th instar (i.e., final instar) and pupal S. frugiperda. JH esterase (JHE) is a critical enzyme that helps to regulate JH levels during insect development. JHE activity in the last instar S. littoralis and S. frugiperda was 11 and 23nmolmin(-1)ml(-1) hemolymph, respectively. Methoprene and pyriproxyfen showed poor inhibition of JHE activity from these insects, whereas fenoxycarb showed stronger inhibition. The inhibitory activity of fenoxycarb, however, was more than 1000-fold lower than that of OTFP, a highly potent inhibitor of JHEs.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Antiparasitic Products


CAS 26002-80-2 Phenothrin

Phenothrin
(CAS: 26002-80-2)

Phenothrin, also called as Forte or Sumithrin, a synthetic pyrethroid, is an antiparasitic drug that is used to kills adult fleas and ticks.

CAS 68813-55-8 Oxantel Pamoate

Oxantel Pamoate
(CAS: 68813-55-8)

Oxantel Pamoate is used as an anthelmintic. It has typically been used human and animal use as a standard treatment for intestinal worms. lt may be used as a fu...

CAS 53716-50-0 Oxfendazole

Oxfendazole
(CAS: 53716-50-0)

Oxfendazole is the sulfoxide form of fenbendazole which is a broad spectrum benzimidazole anthelmintic.

CAS 58306-30-2 Febantel

Febantel
(CAS: 58306-30-2)

Febantel is an anthelmintic for veterinary use on dogs, cats, cattle, sheep, goats, pig and poultry against roundworms and tapeworms, which is a veteran anthelm...

CAS 95233-18-4 Atovaquone

Atovaquone
(CAS: 95233-18-4)

Atovaquone is a medication used to treat or prevent for pneumocystis pneumonia, toxoplasmosis, malaria, and babesia.

CAS 3383-96-8 Temefos

Temefos
(CAS: 3383-96-8)

Temefos or temephos is an an insecticide used to to treat water infested in aquatic situations and on domestic pets.

CAS 1642-54-2 Diethylcarbamazine citrate

Diethylcarbamazine citrate
(CAS: 1642-54-2)

Diethylcarbamazine Citrate can be used as an anthelmintic. The LD50 in rats is 1.38 g/kg.

CAS 59729-37-2 Fexinidazole

Fexinidazole
(CAS: 59729-37-2)

Fexinidazole is effective against trypanosomes caused by infection with species of the protozoan parasite Trypanosoma brucei.

CAS 137-88-2 Amprolium HCl

Amprolium HCl
(CAS: 137-88-2)

Amprolium chloride is a thiamin antagonist, which prevents carbohydrate synthesis by blocking thiamine uptake.

CAS 52645-53-1 Permethrin

Permethrin
(CAS: 52645-53-1)

Permethrin is a synthetic pyrethroid insectide, affecting neuron membranes by prolonging sodium channel activation.

CAS 117772-70-0 Azithromycin Dihydrate

Azithromycin Dihydrate
(CAS: 117772-70-0)

Azithromycin is marginally less active than erythromycin in vitro against Gram-positive organisms, although this is of doubtful clinical significance as suscept...

CAS 1263-89-4 Paromomycin Sulfate

Paromomycin Sulfate
(CAS: 1263-89-4)

Paromomycin Sulfate is an aminoglycoside antibiotics inhibiting protein synthesis in non-resistant cells by binding to 16S ribosomal RNA.

CAS 117704-25-3 Doramectin

Doramectin
(CAS: 117704-25-3)

Doramectin is an antiparasitic agent.

CAS 321-55-1 Haloxon

Haloxon
(CAS: 321-55-1)

Haloxon is an organophosphorus anthelmintic once used against nematodes of the abomasum and small intestine in ruminants.

CAS 74847-35-1 Pyronaridine

Pyronaridine
(CAS: 74847-35-1)

Pyronaridine is an antimalarial drug. Pyronaridine was first synthesized in 1970 and has been in clinical use in China since the 1980s. It is one of the compone...

CAS 33564-30-6 Cefoxitin sodium

Cefoxitin sodium
(CAS: 33564-30-6)

Cefoxitin is is derived from cephamycin C, a semi-synthetic, broad-spectrum cepha antibiotic often grouped with the second-generation cephalosporins.

CAS 7181-73-9 Bephenium

Bephenium
(CAS: 7181-73-9)

Bephenium is an anthelmintic agent formerly used in the treatment of hookworm infections and ascariasis.

CAS 63-45-6 Primaquine Diphosphate

Primaquine Diphosphate
(CAS: 63-45-6)

Primaquine is the only generally available anti-malarial that prevents relapse in vivax and ovale malaria, and the only potent gametocytocide in falciparum mala...

CAS 551-92-8 Dimetridazole

Dimetridazole
(CAS: 551-92-8)

Dimetridazole is a nitroimidazole-based compound that combats protozoan infections, with antibacterial and anticoccidial activity

CAS 2971-90-6 Clopidol

Clopidol
(CAS: 2971-90-6)

Clopidol is an organic compound that is used as in veterinary medicine as a coccidiostat. It is prepared industrially by a multistep process from dehydroacetic ...

Chemical Structure

CAS 40596-69-8 Methoprene

Quick Inquiry

Verification code

Featured Items