Methimazole - CAS 60-56-0
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Not Intended for Therapeutic Use. For research use only.
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Methimazole (also known as Tapazole or Thiamazole or MMI) is an antithyroid drug,and part of the thioamide group. Like its counterpart propylthiouracil, a major side effect of treatment is agranulocytosis.
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Niculescu DA1, Dusceac R2, Galoiu SA1, Capatina CA1, Poiana C1. Endocr Pract. 2016 Apr 4. [Epub ahead of print]
Objective Overt hyperthyroidism and methimazole (MMI) treatment are frequently associated with abnormal liver function tests (LFT). We describe the serial changes of LFT in MMI-treated hyperthyroid patients. Methods We retrospectively analyzed all 77 patients presenting with newly diagnosed overt hyperthyroidism (59 Graves diseases, 11 toxic nodular goiters, 4 toxic adenomas, 3 amiodarone-induced thyrotoxicosis) between 2012-2014. All patients started MMI 10 to 60 mg/day that was gradually tapered. We measeured TSH, freeT4, alanine aminotransferase (ALT) and aspartate aminotrasnferase (AST) at baseline and at 6 weeks, 4.5 months and 10 months after starting the MMI treatment. The concomitant medication was stable during MMI treatment. Results At baseline, 25 patients (32.5%) had abnormal LFT, of which 5 had ALT or AST levels over 2 × upper limit of normal (ULN). In most patients with baseline abnormal LFT, MMI treatment resulted in a normalization of serum ALT and AST.
2.Hampered Lung Maturation in Methimazole-Induced Hypothyroidism in Fetal Chicken: Morphological and Molecular Correlates to Human Fetal Development.
Bjørnstad S1, Samara A, Erichsen A, Paulsen RE, Glover JC, Roald B. Neonatology. 2016;110(2):83-92. doi: 10.1159/000444656. Epub 2016 Apr 13.
BACKGROUND: Molecular understanding of lung development is crucial for developing therapies and diagnostic tools. Animal models with altered thyroid hormone signaling provide mechanistic insight into thyroid-dependent neonatal lung disease. Repression of Klf2 (Krüppel-like factor 2), a suggested T3 target gene, is associated with disrupted lung development in mice. Klf2 is proposed to be specifically involved in type I pneumocyte differentiation.
3.Graves' disease in a mediastinal mass presenting after total thyroidectomy for nontoxic multinodular goiter: a case report.
Cunha FM1,2, Rodrigues E3,4, Oliveira J3,4, Saavedra A3,4, Vinhas LS5, Carvalho D3,4. J Med Case Rep. 2016 Mar 31;10(1):70. doi: 10.1186/s13256-016-0878-7.
BACKGROUND: Thyrotoxicosis after total thyroidectomy is mostly iatrogenic. Rarely, a hyperfunctional thyroid remnant or ectopic tissue may be the cause. There are few cases of Graves' disease arising from thyroid tissue located in the mediastinum and none in which Graves' disease was diagnosed only after surgery. We report the case of a patient with Graves's disease in a mediastinal thyroid mass presenting 7 years after total thyroidectomy for nontoxic goiter.
4.Predicting relapse of Graves' disease following treatment with antithyroid drugs.
Liu L1, Lu H1, Liu Y2, Liu C1, Xun C3. Exp Ther Med. 2016 Apr;11(4):1453-1458. Epub 2016 Feb 9.
The aim of the present study was to monitor long term antithyroid drug treatments and to identify prognostic factors for Graves' disease (GD). A total of 306 patients with GD who were referred to the Endocrinology Clinic at Weifang People's Hospital (Weifang, China) between August 2005 and June 2009 and treated with methimazole were included in the present study. Following treatment, patients were divided into non-remission, including recurrence and constant treatment subgroups, and remission groups. Various prognosis factors were analyzed and compared, including: Patient age, gender, size of thyroid prior to and following treatment, thyroid hormone levels, disease relapse, hypothyroidism and drug side-effects, and states of thyrotropin suppression were observed at 3, 6 and 12 months post-treatment. Sixty-five patients (21.2%) were male, and 241 patients (78.8%) were female. The mean age was 42±11 years, and the follow-up was 31.5±6.8 months.
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CAS 60-56-0 Methimazole

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