Methacycline Hydrochloride - CAS 3963-95-9
Catalog number: 3963-95-9
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
Molecular Weight:
Methacycline HCl is a tetracycline antibiotic, and also an inhibitor of epithelial–mesenchymal transition (EMT) with IC50 of roughly 5 μM, used to treat various infections.
Publictions citing BOC Sciences Products
  • >> More
1.[Comparative evaluation of methacycline hydrochloride capsules and tablets according to their dissolubility and rate of solution].
Berezovskaia LN, Grakovskaia LK, Nesterova LIa. Antibiotiki. 1979 Aug;24(8):604-8.
Desintegration and dissolution of capsules and tablets of methacycline hydrochloride were studied. The study on solubility of methacycline hydrochliride capsules filled with methacycline granulate or powder according to the same formula showed that the rate of the antibiotic liberation from the capsules filled with the powder decreased during storage while that from the capsules filled with the granulate did not change. Investigation of the effect of the mass packing value in a drop on the antibiotic liberation from the capsules showed that an increase in the packing coefficient above 1.38 resulted in a marked decrease in the rate of methacycline liberation from the capsules filled with the granulate. No correlation between desintegration and dissolution of methacycline capsules and tablets was found.
2.[Drug induced esophageal ulcers].
Hügel HE, Schinko H, Bischof HP. Z Gastroenterol. 1982 Oct;20(10):599-603.
Drug induced esophageal ulcers are more frequent than supposed. Four ulcerative lesions of the esophagus, two after ingestion of doxycycline-hydrochloride, one after metacycline-hydrochloride, and one after emeproniumbromide were detected at the department of Internal Medicine of a medium-sized standard-hospital during the last six years. Symptoms develop suddenly after taking the drug with minimum fluid, usually before going to bed. Retrosternal burning, odynophagia and dysphagia are pathognomonic features. The cause of ulceration is discussed to be a matter of the drug remaining in the esophagus and of its local cytolytic and corrosive effect. Cytomegalo and herpes-simplex-infections can be excluded as etiologic factor of such ulcers. The clinical diagnosis is verified by endoscopy only.
3.Colorimetric determination of tetracycline derivatives in pharmaceutical preparations.
Saha U1. J Assoc Off Anal Chem. 1989 Mar-Apr;72(2):242-4.
A quick colorimetric method is reported for the determination of tetracycline derivatives such as oxytetracycline hydrochloride (OTCH), chlortetracycline hydrochloride (CTCH), methacycline hydrochloride (MCH), and doxycycline hydrochloride (DCH). The method involves complexation of the above derivatives with cupric chloride in alkaline medium. The yellowish green copper complexes of OTCH, CTCH, MCH, and DCH show maximum absorbance at 395, 410, 400, and 400 nm, respectively. The color intensity obeys Beer's law in the concentration range of 0-20 micrograms/mL.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Antibacterial Products

CAS 140-64-7 Pentamidine isethionate

Pentamidine isethionate
(CAS: 140-64-7)

The diisethionate salt form of Pentamidine, an amidine derivative, has been found to have antiprotozoal and antifungal effect and could be commonly used against...

CP 6232
(CAS: 141562-38-1)

CP 6232 is a new anti-pseudomonal cephalosporin as a cell wall inhibitor. It was developed by Meiji Seika Pharma. Research for the treatment of bacterial infect...

CAS 12650-69-0 Mupirocin

(CAS: 12650-69-0)

Mupirocin is an isoleucyl t-RNA synthetase inhibitor, used in the treatment of bacterial skin infections.

CAS 122841-12-7 Cefoselis sulfate

Cefoselis sulfate
(CAS: 122841-12-7)

Cefoselis sulfate is a stable cephalosporin for BETA-lactamase. The drug shows antimicrobial activity for a wide range of bacteria including Pseudomonas.

CAS 10592-13-9 Doxycycline HCl

Doxycycline HCl
(CAS: 10592-13-9)

Doxycycline HCl is a tetracycline antibiotic that commonly used to treat a variety of infections and MMP inhibitor.

CAS 31282-04-9 Hygromycin B

Hygromycin B
(CAS: 31282-04-9)

Hygromycin B, a selective antibiotic that is effective on most bacteria, fungi and higher eukaryotes, inhibits protein synthesis by interfering with translocati...

CAS 127-79-7 Sulfamerazine

(CAS: 127-79-7)

Sulfamerazine is a sulfonamide antibacterial.

CAS 100986-85-4 Levofloxacin

(CAS: 100986-85-4)

Levofloxacin is as efficacious as or more efficacious than that with ciprofloxacin in systemic as well as pyelonephritis infections in mice. Levofloxacin achiev...

CAS 13412-64-1 Dicloxacillin sodium monohydrate

Dicloxacillin sodium monohydrate
(CAS: 13412-64-1)

The sodium monohydrate salt form of Dicloxacillin, a β-Lactam compound, could be used as an antibiotic especially against Gram-positive bacteria and also be sig...

(CAS: 432038-96-5)

CP-5609 is a novel carbapenem with enhanced antimicrobial activities.

LY 215890
(CAS: 153502-35-3)

LY 215890 has been found to have probable antibiotic activity.

CAS 7081-44-9 Cloxacillin Sodium

Cloxacillin Sodium
(CAS: 7081-44-9)

Cloxacillin Sodium is a sodium salt of cloxacillin that is a penicillinase-resistant, acid resistant, semi-synthetic penicillin.

CAS 120410-24-4 Biapenem

(CAS: 120410-24-4)

Biapenem (INN) is a carbapenem antibiotic. It has in vitro activity against anaerobes.

CAS 37693-01-9 Clofoctol

(CAS: 37693-01-9)

Clofoctol is a bacteriostatic antibiotic used to against gram-positive bacteria.

CAS 4697-36-3 Carbenicillin

(CAS: 4697-36-3)

Carbenicillin is broad-spectrum semisynthetic penicillin derivative used parenterally. It is a semi-synthetic penicillin antibiotic which interferes with cell w...

CAS 21462-39-5 Clindamycin HCl

Clindamycin HCl
(CAS: 21462-39-5)

Clindamycin hydrochloride(Dalacin) is the hydrated hydrochloride salt of clindamycin which is a semisynthetic antibiotic. Clindamycin is a lincosamide antibioti...

CAS 91832-40-5 Cefdinir

(CAS: 91832-40-5)

Cefdinir is a semi-synthetic, broad-spectrum antibiotic, used for soft tissue infections and respiratory tract infections

CAS 122-16-7 Sulfanitran

(CAS: 122-16-7)

Sulfanitran, a sulfonamide derivative, could be commonly used as an anticoccidial drug for animals.

CAS 21736-83-4 Spectinomycin Hydrochloride

Spectinomycin Hydrochloride
(CAS: 21736-83-4)

Spectinomycin is an antibiotic useful for the treatment of the bacterial infection, gonorrhea.It is marketed as the hydrochloride salt spectinomycin hydrochlori...

CAS 24168-96-5 Isoconazole nitrate

Isoconazole nitrate
(CAS: 24168-96-5)

Isoconazole nitrate (Travogen) is an azole antifungal reagent.Nigerian and British medical researchers found that for foot and vaginal infections, isoconazole h...

Chemical Structure

CAS 3963-95-9 Methacycline Hydrochloride

Quick Inquiry

Verification code

Featured Items