Metaxalone - CAS 1665-48-1
Catalog number: 1665-48-1
Category: Inhibitor
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Molecular Formula:
C12H15NO3
Molecular Weight:
221.25
COA:
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Targets:
Others
Description:
Metaxalone is a muscle relaxant. The mechanism of action of metaxalone in humans is not fully understood. It was suggested that it acts through general central nervous system depression..
Purity:
>98%
Synonyms:
AHR438; NSC170959; AHR 438; NSC 170959; AHR-438; NSC-170959; Skelaxin
MSDS:
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InChIKey:
IMWZZHHPURKASS-UHFFFAOYSA-N
InChI:
InChI=1S/C12H15NO3/c1-8-3-9(2)5-10(4-8)15-7-11-6-13-12(14)16-11/h3-5,11H,6-7H2,1-2H3,(H,13,14)
Canonical SMILES:
CC1=CC(=CC(=C1)OCC2CNC(=O)O2)C
1. Inappropriate medication prescribing in community-dwelling elderly people living in Iran
Laurent Azoulay . Amir Zargarzadeh . Zeinab Salahshouri . Driss Oraichi . Anick Bérard. Eur J Clin Pharmacol (2005) 61: 913–919
Beers’ updated explicit criteria shown in Table 1 were used to define medications considered inappropriate irrespective of medical conditions from the entire list of medications prescribed at the time of the visit. The criteria included medications that unnecessarily place the elderly at high risk of having an adverse drug reaction. Using the classification system of Zhan et al., the medications listed in Table 1 were further categorized into three groups: medications 1) that should always be avoided (barbiturates, flurazepam, meprobamate, chlorpropamide, meperidine, pentazocine, trimethobenzamide, belladonna alkaloids, dicyclomine, hyoscyamine, propantheline), 2) that are rarely appropriate (chlordiazepoxide, diazepam, propoxyphene, carisoprodol, chlorzoxazone, cyclobenzaprine, metaxalone, methocarbamol) and 3) that have some indications but are often misused (amitriptyline, doxepin, indomethacin, dipyridamole, ticlopidine, methyldopa, reserpine, disopyramide, oxybutynin, chlorpheniramine, cyproheptadine, diphenhydramine, hydroxyzine, promethazine). Five medications present in the Beers [11] criteria were not classified by the Zhan et al. expert panel: cyclospasmol, ergot mesyloids, phenylbutazone, dexchlorpheniramine, and tripelennamine.
2. LC-MS–MS Determination of Pregabalin in Human Plasma
Vikas V. Vaidya, Santosh M. Yetal, Shikha M. N. Roy, Noel A. Gomes, Santosh S. Joshi. Chromatographia 2007, 66, December (No. 11/12)
The electrospray ionization of pregabalin and metaxalone produced the abundant protonated molecules ([MH+]) at m/z 160.2 and 222.2, respectively under positive ionization conditions, with evidence of adduct formation. The quantification of the analysis was performed using the MRM mode due to high selectivity and sensitivity of MRM data acquisitions: Pregabalin 160.2 > 142.2 and metaxalone 222.2 > 161.1. LC-MS–MS methods operated with the revere phase C18 column and low aqueous-high organic mobile phase have been proven to be ideal for the analysis of polar compounds in biological fluids. The higher organic content in the mobile phase resulted in the sensitivity improvement via enhancement of ionization yield. It is desirable to use isotope-labled or a structure similar internal standard in an LC-MS–MS procedure. However such compounds are not commercially available. In this study, a simple deproteinized procedure was used to treat the sample, therefore, metaxalone with similar chromatographic retention to its analyte was used as internal standard. Protein precipitation with acetronitrile was used with 500 lL plasma. The proposed method, proved to be accurate and selective, meeting the standards of bioanalysis method validation accepted by FDA.
3. LC-MS-MS Development and Validation for Quantitative Determination of Methoxsalen in Human Plasma
Noel Alex Gomes, Vikas V. Vaidya, Ashutosh M. Pudage. Chromatographia 2009, 69, May (No. 9/10)
A Hypurity C18, (50 9 4.6 mm), 5 μ column obtained from Thermo Electron, Mumbai, India was used for the compound retention. The mobile phase consisted of acetonitrile–2 mM ammonium acetate buffer (80:20, v/v), delivered at a flow rate of 0.4 mL min-1 by an Shimadzu Prominence series (Kyoto, Japan) binary pump. Detection of methoxsalen and metaxalone (IS) was achieved using an Applied Biosystems API 3200MS-MS apparatus (Applied Biosystems, Ontario, Canada) fitted with a TurboIonSpray source. Electrospray ionization (ESI) was performed in the positive ion mode with nitrogen as the collision gas. The spray voltage and source temperature were 5,500 V and 450 ℃, respectively. The declustering potential (DP), collision energy (CE), entrance potential (EP), cell exit potential (CXP) were optimized during tuning as 46, 37, 5.5, 6; 40, 15, 5, 5 eV for methoxsalen and metaxalone, respectively. The collision activated dissociation (CAD) gas was set at 6 psi, while the curtain gas was set at 10 psi. The mass spectrometer was operated at unit resolution in the multiple reaction monitoring (MRM) mode, monitoring the transition of the protonated molecular ion m/z 217.1 to the product ion m/z 174.3 for methoxsalen and the transition of the protonated molecular ion m/z 222.2 to the product ion m/z 161.2 for the internal standard, metaxalone. Applied Biosystems Analyst version 1.4.2 software was used for instrument control and data acquisition.
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CAS 1665-48-1 Metaxalone

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