Metaraminol tartrate - CAS 33402-03-8
Catalog number: 33402-03-8
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
Molecular Weight:
Adrenergic Receptor
Metaraminol is a stereoisomer of meta-hydroxynorephedrine, acts as An adrenergic agonist that increases both systolic and diastolic blood pressure.
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White powder
3-[(1R,2S)-2-amino-1-hydroxypropyl]phenol;2,3-dihydroxybutanedioic acid
10 mM in H2O
Store at R. T.
Used in the prevention and treatment of hypotension, particularly as a complication of anesthesia
Quality Standard:
Enterprise Standard/USP
Shelf Life:
As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly
Boiling Point:
357.9ºC at 760 mmHg
Melting Point:
Canonical SMILES:
Current Developer:
1.High-throughput screening of FDA-approved drugs using oxygen biosensor plates reveals secondary mitofunctional effects.
Sahdeo S1, Tomilov A1, Komachi K2, Iwahashi C3, Datta S1, Hughes O2, Hagerman P3, Cortopassi G1. Mitochondrion. 2014 Jul;17:116-25. doi: 10.1016/j.mito.2014.07.002. Epub 2014 Jul 14.
Repurposing of FDA-approved drugs with effects on mitochondrial function might shorten the critical path to mitochondrial disease drug development. We improved a biosensor-based assay of mitochondrial O2 consumption, and identified mitofunctional defects in cell models of LHON and FXTAS. Using this platform, we screened a 1600-compound library of clinically used drugs. The assay identified drugs known to affect mitochondrial function, such as metformin and decoquinate. We also identified several drugs not previously known to affect mitochondrial respiration including acarbose, metaraminol, gallamine triethiodide, and acamprosate. These previously unknown 'mitoactives' represent novel links to targets for mitochondrial regulation and potentially therapy, for mitochondrial disease.
2.A comparison of three vasopressors for tight control of maternal blood pressure during cesarean section under spinal anesthesia: Effect on maternal and fetal outcome.
Bhardwaj N1, Jain K, Arora S, Bharti N. J Anaesthesiol Clin Pharmacol. 2013 Jan;29(1):26-31. doi: 10.4103/0970-9185.105789.
PURPOSE: Maintaining systolic blood pressure (SBP) at 100% of baseline is best for fetal and maternal outcome. We hypothesized that irrespective of the vasopressor used, maintaining SBP at 100% of baseline with phenylephrine (P), metaraminol (M), or ephedrine (E) will produce the best fetal pH after cesarean section (LSCS) under subarachnoid block (SAB).
3.Propofol for adult procedural sedation in a UK emergency department: safety profile in 1008 cases.
Newstead B1, Bradburn S, Appelboam A, Reuben A, Harris A, Hudson A, Jones L, McLauchlan C, Riou P, Jadav M, Lloyd G. Br J Anaesth. 2013 Oct;111(4):651-5. doi: 10.1093/bja/aet168. Epub 2013 May 9.
BACKGROUND: Concerns exist regarding the safe use of propofol by Emergency Physicians for procedural sedation. The World SIVA International Sedation Task Force has recently created an adverse event tool, in an effort to standardize reporting. We present a safety analysis of our use of propofol using this tool.
4.Vasoconstrictor responses to vasopressor agents in human pulmonary and radial arteries: an in vitro study.
Currigan DA1, Hughes RJ, Wright CE, Angus JA, Soeding PF. Anesthesiology. 2014 Nov;121(5):930-6. doi: 10.1097/ALN.0000000000000430.
BACKGROUND: Vasopressor drugs, commonly used to treat systemic hypotension and maintain organ perfusion, may also induce regional vasoconstriction in specialized vascular beds such as the lung. An increase in pulmonary vascular tone may adversely affect patients with pulmonary hypertension or right heart failure. While sympathomimetics constrict pulmonary vessels, and vasopressin does not, a direct comparison between these drugs has not been made. This study investigated the effects of clinically used vasopressor agents on human isolated pulmonary and radial arteries.
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CAS 33402-03-8 Metaraminol tartrate

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