|Description||Mesopram is an orally active, selective phosphodiesterase (PDE) 4 inhibitor. In vitro, mesopram selectively inhibits the activity of type 1 helper T (Th1) cells without affecting cytokine production or proliferation of type 2 helper T (Th2) cells. It decreases the synthesis of tumor necrosis factor-alpha (TNF-alpha) and interferon-gamma (IFN-gamma). Some studies conclude that the specific type-4 phosphodiesterase inhibitor mesopram ameliorates murine colitis both in a preventive and a therapeutic setting.|
|Purity||≥98% by HPLC|
|Storage||Store in a cool and dry place (or refer to the Certificate of Analysis).|
RS 25344 hydrochloride
RS 25344 hydrochloride is a potent and selective inhibitor of four cloned isoforms of PDE4 (A, B, C and D) and phosphorylated PDE4D (IC50= 0.28, > 100, 160 and ...
Trequinsin hydrochloride is a highly potent inhibitor of cGMP-inhibited phosphodiesterase (PDE3) (IC50 = 250 pM). Trequinsin stimulates cAMP accumulation at a c...
Small molecule inhibitor of the KRAS–PDEδ interaction that impairs oncogenic KRAS signalling by altering its localization to endomembranes (in cell Kd value 41 ...
Olprinone(Loprinone) is a selective phosphodiesterase 3 (PDE3) inhibitor.
Denaverine hydrochloride is a phosphodiesterase inhibitor.Denaverine hydrochloride is applied in relaxation and delatation of birth canal in animals and spasms ...
A potent, orally active and dual inhibitor of phosphodiesterase 4 (PDE4) (IC50= 1.1 μM) and tumor necrosis factor-α (TNF-α) (IC50= 2.5 μM).
Thioquinapiperifil is a phosphodiesterase-5 (PDE-5) inhibitor used as a dietary supplement.
Tadalafil binds to PDE5 with KD of 2.4 nM.