Meprednisone - CAS 1247-42-3
Catalog number:
1247-42-3
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C22H28O5
Molecular Weight:
372.455
COA:
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Targets:
Glucocorticoid Receptor
Description:
Meprednisone is a glucocorticoid and a methylated derivative of prednisone.
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Purity:
>98%
Synonyms:
NSC 527579, SCH 4358
MSDS:
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1.Comparative analysis the binding affinity of mycophenolic sodium and meprednisone with human serum albumin: Insight by NMR relaxation data and docking simulation.
Ma X1, He J1, Yan J1, Wang Q1, Li H2. Chem Biol Interact. 2016 Mar 25;248:52-9. doi: 10.1016/j.cbi.2016.02.009. Epub 2016 Feb 16.
Mycophenolic sodium is an immunosuppressive agent that is always combined administration with corticosteroid in clinical practice. Considering the distribution and side-effect of the drug may change when co-administrated drug exist, this paper comparatively analyzed the binding ability of mycophenolic sodium and meprednisone toward human serum albumin by nuclear magnetic resonance relaxation data and docking simulation. The nuclear magnetic resonance approach was based on the analysis of proton selective and non-selective relaxation rate enhancement of the ligand in the absence and presence of macromolecules. The contribution of the bound ligand fraction to the observed relaxation rate in relation to protein concentration allowed the calculation of the affinity index. This approach allowed the comparison of the binding affinity of mycophenolic sodium and meprednisone. Molecular modeling was operated to simulate the binding model of ligand and albumin through Autodock 4.
2.Granulomatosis with polyangiitis: recurrence presenting as ependimoplexitis.
Pisoni CN1, Ibañez S, Guevara M, Castro D, Romero Vidomlansky S. Clin Exp Rheumatol. 2014 May-Jun;32(3 Suppl 82):S70-2. Epub 2014 Mar 17.
A 55-year-old man with granulomatosis with polyangiitis (GPA) developed continuous parietal headache, malaise, nasal crusting and dry cough. Neurological exam revealed only left hand hypoesthesia in 4th and 5th finger. Brain MRI showed enlarged right choroid plexus, hyperintense periventricular white matter, thalami and right side of corpus callosum. The suspected diagnosis was ependimoplexitis due to GPA, the patient received three 500 mg methylprednisolone pulses followed by 1 mg/kg of meprednisone with gradual tapering and was switched to oral cyclophosphamide. He had complete resolution of headache. An MRI following this treatment for relapse revealed only minimal ependimal changes.
3.Effect of premedication with systemic steroids on surgical field bleeding and visibility during nasosinusal endoscopic surgery.
Fraire ME1, Sanchez-Vallecillo MV, Zernotti ME, Paoletti OA. Acta Otorrinolaringol Esp. 2013 Mar-Apr;64(2):133-9. doi: 10.1016/j.otorri.2012.09.009. Epub 2013 Jan 11.
INTRODUCTION: Chronic rhinosinusitis (CRS) is the inflammation of the nasal and paranasal sinus mucosa persisting for at least 12 weeks. The success of endoscopic sinus surgery (ESS) depends on minimising oedema and intraoperative bleeding. For this purpose, some surgeons advocate the use of preoperative systemic steroids (SS). Our aim was to assess if the administration of preoperative SS in patients with CRS with or without nasal polyps (NP) facilitates the surgical procedure.
4.Autoimmune cholangitis associated to IgG4 related sclerosing disease.
Frider B1, Bruno A, Zylberman M, Oría A, Amante M. Acta Gastroenterol Latinoam. 2011 Mar;41(1):55-9.
The IgG4-related sclerosing disease is characterized by the presence of plasmatic IgG4 positive cells and T-lymphocytes infiltration in different organs. We herein report a case of cholestasis due to autoimmune cholangitis associated to IgG4 disease. A 40-year-old woman with a history of pruritus, anosmia, Sjögren's syndrome and diabetes, was referred for a pancreatic tumor. Alkaline phosphatase was 24-fold upper limit of normal (ULN), gamma-glutamyl transpeptidase 21-fold ULN, aspartate aminotransferase 3-fold ULN, alanine aminotransferase 2-fold ULN, cholesterol 408 mg/dL, bilirubin normal, gamma-globulin 3.92 g/dL, IgG4 4.6 g/L, antinuclear antibody positive (1/320), and antimitochondrial antibodies negative. Ultrasound scan (US) showed a mass in the pancreatic head and thickening of the gallbladder and the bile duct walls. Dilation and strictures of the main pancreatic duct and intrahepatic bile ducts were detected by MR cholangiopancreatography.
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CAS 1247-42-3 Meprednisone

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