Mepivacaine HCl - CAS 1722-62-9
Catalog number:
1722-62-9
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C15H22N2O.HCl  
Molecular Weight:
282.81
COA:
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Targets:
Sodium Channel
Description:
Mepivacaine is a tertiary amine used as a local anesthetic.
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Purity:
>98%
MSDS:
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1.Intrathecal amantadine for prolonged spinal blockade of sensory and motor functions in rats.
Tzeng JI1, Kan CD2, Wang JN3, Wang JJ4, Lin HT5,6, Hung CH7,8. Fundam Clin Pharmacol. 2016 Mar 24. doi: 10.1111/fcp.12200. [Epub ahead of print]
We aimed to compare the hypothesized local anesthetic action of amantadine (1-adamantanamine) with that of the known local anesthetic mepivacaine. Motor, proprioceptive and nociceptive functions were evaluated in rats after intrathecal administration. Amantadine elicited spinal anesthesia in a dose-related fashion and produced a better sensory-selective action over motor blockade (p<0.01). On the 50% effective dose (ED50 ) basis, the rank of potency on spinal motor, proprioceptive and nociceptive block was mepivacaine > amantadine (p<0.01 for the differences). Amantadine (63.5 μmol/kg) and mepivacaine (7.1 μmol/kg) produced complete spinal block of motor function, proprioception and nociception. On an equipotent basis (ED25 , ED50 , and ED75 ), the duration of amantadine was longer (p<0.01) than that of mepivacaine on spinal motor, proprioceptive and nociceptive block. Our preclinical data demonstrated that amantadine was less potent than mepivacaine at producing spinal anesthesia.
2.Cardiovascular effects of combined hyaluronidase and mepivacaine in dental anesthesia: A randomized clinical trial.
Tornelli MJ, Prado RM, Tornelli HR, Prado GF, Viera PV, Rocha RG, Borsatti MA. Am J Dent. 2016 Feb;29(1):10-4.
PURPOSE: To evaluate the effects of combined administration of mepivacaine with epinephrine and the diffusion agent hyaluronidase on hemodynamic and electrocardiographic parameters in healthy individuals undergoing dental surgery.
3.Plasma mepivacaine concentrations in patients undergoing third molar surgery.
Scarparo HC1, Maia RN2, Filho EA3, Soares EC4, Costa FW5, Fonteles CS6, Bezerra TP7, Ribeiro TR6, Romero NR3. Aust Dent J. 2016 Jan 18. doi: 10.1111/adj.12410. [Epub ahead of print]
BACKGROUND: Local anesthesic-related systemic toxicity mainly results from elevated plasma concentrations of these drugs. We hypothesized that intraoral injection of submaximum doses of mepivacaine does not lead to toxic levels of this drug in blood. This study evaluated the plasma levels of mepivacaine in third molars surgeries.
4.Lipid Emulsion Inhibits Vasodilation Induced by a Toxic Dose of Bupivacaine via Attenuated Dephosphorylation of Myosin Phosphatase Target Subunit 1 in Isolated Rat Aorta.
Ok SH1, Byon HJ2, Kwon SC3, Park J4, Lee Y4, Hwang Y4, Baik J5, Choi MJ6, Sohn JT7. Int J Med Sci. 2015 Nov 5;12(12):958-67. doi: 10.7150/ijms.13299. eCollection 2015.
Lipid emulsions are widely used for the treatment of systemic toxicity that arises from local anesthetics. The goal of this in vitro study was to examine the cellular mechanism associated with the lipid emulsion-mediated attenuation of vasodilation induced by a toxic dose of bupivacaine in isolated endothelium-denuded rat aorta. The effects of lipid emulsion on vasodilation induced by bupivacaine, mepivacaine, and verapamil were assessed in isolated aorta precontracted with phenylephrine, the Rho kinase stimulant NaF, and the protein kinase C activator phorbol 12,13-dibutyrate (PDBu). The effects of Rho kinase inhibitor Y-27632 on contraction induced by phenylephrine or NaF were assessed. The effects of bupivacaine on intracellular calcium concentrations ([Ca(2+)]i) and tension induced by NaF were simultaneously measured. The effects of bupivacaine alone and lipid emulsion plus bupivacaine on myosin phosphatase target subunit 1 (MYPT1) phosphorylation induced by NaF were examined in rat aortic vascular smooth muscle cells.
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CAS 1722-62-9 Mepivacaine HCl

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