|Description||Mepenzolate Bromide is a muscarinic antagonist used to treat gastrointestinal disorders, and decreases the severity of elastase-induced airspace enlargement and respiratory dysfunction.|
Milameline is a non-selective muscarinic acetylcholine receptor partial agonist at all receptor subtypes (Ki values are 2.3, 2.4, 3.6, 3.8 and 4.3 μM for hM1, h...
VU 6008667 is a selective negative allosteric modulator (NAM) of M5 muscarinic acetylcholine receptor (mAChR) (IC50 values of 1.2 and 1.6 μM in human and rat M5...
Nuvenzepine, a new pirenzepine-analog, is an mAChR antagonist, administered intraduodenally, displayed a long-lasting and dose-dependent inhibition of neostigmi...
MK-0969 is an Muscarinic M3 antagonist which has the potential for the treatment of chronic obstructive pulmonary diseases.
Irsogladine is a PDE4 inhibitor and muscarinic acetylcholine receptor binder. It inhibits bFGF-induced angiogenesis in wild-type, tPA-knockout, and uPA-knockout...
Benzhexol HCl is an anticholinergic tertiary amine used to treat parkinsonism and the extrapyramidal side effects of anti-psychotic drugs.
YM-46303 is an mAChR antagonist which had a binding affinity of 0.39 nM to M3-receptors. YM-46303 exhibits the highest affinities for M1 and M3 receptors. YM-46...
Biperiden is an antiparkinsonian agent, which is the selective central M1 cholinoreceptors blocker. It is used for the adjunctive treatment of all forms of Park...
Arecaidine But-2-ynyl Ester Tosylate (ABET) is a potent and selective agonist of M2 recceptors in the atrium versus those in the ileum.
BQCA is a highly selective positive allosteric modulator of the M1 muscarinic acetylcholine receptor (mAChR), as it dose-dependently reduces the concentration o...
MK-7622 is a cholinesterase inhibitor under evaluation for the treatment of Alzheimer's disease. No studies have been published on this compound in the peer-rev...
Tiotropium Bromide hydrate
Tiotropium Bromide hydrate is a monohydrate of tiotropium bromide (Spiriva; Tiova; BA 679BR; tiopropium) that is an anticholinergic and bronchodilator and a mus...
Desfesoterodine is the active metabolite of fesoterodine as its isobutyrate ester.
Irsogladine is a PDE4 inhibitor and muscarinic acetylcholine receptor binder.Irsogladine treatment (300 and 500 mg/kg/day) resulted in a dose-dependent reductio...
Diphemanil Methylsulfate is a quaternary ammonium anticholinergic.It binds muscarinic acetycholine receptors (mAchR).
Ipratropium bromide, under the trade name Atrovent, structurally similar to atropine, is a muscarinic antagonist and a bronchodilator.
Cevimeline hydrochloride hemihydrate
Cevimeline is a muscarinic M1 and M3 receptor agonist. Cevimeline stimulates secretion by the salivary glands and is used to treat the symptoms of dry mouth. Ce...
Homatropine Bromide is an muscarinic AChR antagonist, inhibits endothelial and smooth muscle muscarinic receptors of WKY-E and SHR-E with IC50 of 162.5 nM and 1...
Fesoterodine Fumarate is an antimuscarinic agent and is rapidly de-esterified to its active metabolite 5-hydroxymethyl tolterodine that is a muscarinic receptor...
CDD0102 is a selective M1 agonist which stimulated the secretion of APP from CHO-K1 cells expressing M1 receptors and penetrated into the brain following i.p. a...