Melatonin - CAS 73-31-4
Catalog number: B0084-302428
Category: Inhibitor
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Molecular Formula:
C13H16N2O2
Molecular Weight:
232.28
COA:
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Targets:
Others
Description:
Melatonin is a hormone produced in the brain by the pineal gland from the amino acid tryptophan. It can be used as an antioxidant. Melatonin is involved in many biological functions such as circadian rhythm, sleep, the stress response, aging, and immunity.
Nutritional supplement in health care products.
Ordering Information
Catalog Number Size Price Stock Quantity
B0084-302428 20 g $189 In stock
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Brife Description:
hormone, antioxidant therapy
Purity:
>98%
Appearance:
Solid powder
Synonyms:
ML-236B; ML 236B; ML236B; Melatonine; N-Acetyl-5-methoxytryptamine; Circadin; 5-Methoxy-N-acetyltryptamine
Solubility:
>34.8 ug/mL
MSDS:
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Application:
Ingredient of health care products.
Melting Point:
117 °C
InChIKey:
DRLFMBDRBRZALE-UHFFFAOYSA-N
InChI:
InChI=1S/C13H16N2O2/c1-9(16)14-6-5-10-8-15-13-4-3-11(17-2)7-12(10)13/h3-4,7-8,15H,5-6H2,1-2H3,(H,14,16)
Canonical SMILES:
CC(=O)NCCC1=CNC2=C1C=C(C=C2)OC
1.Effects and mechanisms of melatonin on neural differentiation of induced pluripotent stem cells.
Shu T1, Wu T2, Pang M1, Liu C1, Wang X1, Wang J3, Liu B1, Rong L4. Biochem Biophys Res Commun. 2016 Apr 26. pii: S0006-291X(16)30613-1. doi: 10.1016/j.bbrc.2016.04.108. [Epub ahead of print]
Melatonin, a lipophilic molecule mainly synthesized in the pineal gland, has properties of antioxidation, anti-inflammation, and antiapoptosis to improve neuroprotective functions. Here, we investigate effects and mechanisms of melatonin on neural differentiation of induced pluripotent stem cells (iPSCs). iPSCs were induced into neural stem cells (NSCs), then further differentiated into neurons in medium with or without melatonin, melatonin receptor antagonist (Luzindole) or Phosphatidylinositide 3 kinase (PI3K) inhibitor (LY294002). Melatonin significantly promoted the number of neurospheres and cell viability. In addition, Melatonin markedly up-regulated gene and protein expression of Nestin and MAP2. However, Luzindole or LY294002 attenuated these increase. The expression of pAKT/AKT were increased by Melatonin, while Luzindole or LY294002 declined these melatonin-induced increase. These results suggest that melatonin significantly increased neural differentiation of iPSCs via activating PI3K/AKT signaling pathway through melatonin receptor.
2.Sustained release of melatonin: A novel approach in elevating efficacy of tamoxifen in breast cancer treatment.
Sabzichi M1, Samadi N2, Mohammadian J3, Hamishehkar H4, Akbarzadeh M5, Molavi O6. Colloids Surf B Biointerfaces. 2016 Apr 22;145:64-71. doi: 10.1016/j.colsurfb.2016.04.042. [Epub ahead of print]
BACKGROUND: Finding advanced anti-cancer agents with selective toxicity in tumor tissues is the goal of anticancer delivery systems. This study investigated potential application of nanostructured lipid carriers (NLCs) in increasing melatonin induced cytotoxicity and apoptosis in MCF-7 breast cancer cells.
3.Exogenous melatonin improved potassium content in Malus under different stress conditions.
Li C1, Liang B1, Chang C1, Wei Z1, Zhou S1, Ma F1. J Pineal Res. 2016 May 4. doi: 10.1111/jpi.12342. [Epub ahead of print]
Melatonin mediates many physiological processes in plants. We investigated its role in regulating growth, potassium uptake, and root system architecture under three types of stress: salinity or a deficiency of all nutrients in Malus hupehensis Rehd., as well as a K-deficiency in M. rockii Rehd. Each treatment caused a reduction in growth rates and disrupted the absorption of potassium. However, pre-treatment with 0.1 μM melatonin significantly alleviated such inhibitions. The addition of melatonin also up-regulated genes for antioxidant enzymes involved in the ascorbate-glutathione cycle (MdcAPX, MdDHAR1, MdDHAR2, MdMDHAR, and MdcGR) and helped decrease the accumulation of H2 O2 while improving the expression of K-transporters and genes for the CBL1-CIPK23 pathway. These results indicated that melatonin can regulate the ROS signal and activate the CBL1-CIPK23 pathway to regulate the expression of a potassium channel protein gene, thereby promoting the absorption of potassium ions.
4.Polymorphism of the melatonin receptor 1A (MNTR1A) gene and association with seasonality of reproductive activity in a local Greek sheep breed.
Giantsis IA1, Laliotis GP1, Stoupa O1, Avdi M1. J Biol Res (Thessalon). 2016 Apr 29;23:9. doi: 10.1186/s40709-016-0050-y. eCollection 2016.
BACKGROUND: Sheep's reproductive physiology in temperate latitudes (such as Greece), is characterized by seasonality and is also regulated by photoperiodic exposure. Melatonin is the key hormone involved in this regulation. However, the melatonin secretion and therefore the ewes reproductive activity underlies variation, proposed to be linked with the melatonin receptor subtype 1A (MNTR1A) gene structure. This study was designed to investigate the polymorphism of the MNTR1A gene in a local Greek sheep breed and to determine its potential association with reproductive seasonality.
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CAS 73-31-4 Melatonin

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