Meglutol - CAS 503-49-1
Catalog number: 503-49-1
Category: Inhibitor
Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Molecular Formula:
C6H10O5
Molecular Weight:
162.14
COA:
Inquire
Targets:
HMG-CoA Reductase (HMGCR)
Description:
Meglutol is a hypolipidemic agent which inhibits the activity of hydroxymethylglutarryl CoA reductases.
Purity:
≥95%
Appearance:
White to Off-White Solid
Synonyms:
Lipoglutaren; Meglutol; HMGA; NSC 361411; NSC-361411; NSC361411; CB-337; CB 337; CB337;3-Hydroxy-3-methylpentane-1,5-dioic Acid;3-Hydroxy-3-methylglutaric acid; Dicrotalic acid; 3-Hydroxy-3-methylpentanedioic acid;
Solubility:
Soluble in DMSO
Storage:
Store at -20 °C
MSDS:
Inquire
Application:
A hypolipidemic agent
Quality Standard:
Enterprise Standard/USP
Shelf Life:
As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly
Quantity:
Milligrams-Grams
Melting Point:
106-110 °C
InChIKey:
NPOAOTPXWNWTSH-UHFFFAOYSA-N
InChI:
1S/C6H10O5/c1-6(11,2-4(7)8)3-5(9)10/h11H,2-3H2,1H3,(H,7,8)(H,9,10)
Canonical SMILES:
CC(CC(=O)O)(CC(=O)O)O
1.A comparison of the uptake of 3-hydroxy-3-methyl-glutaric acid in newborn and adult rat kidney.
Roth KS;Serabian M;Medow MS Metabolism. 1982 Apr;31(4):406-10.
The developmental aspects of the renal uptake of 3-OH-3-CH3-glutaric acid (HMG) was examined using isolated renal tubules prepared from both newborn and adult rats and isolated renal brush border membranes vesicles from adult rats. The accumulation of 70 microM HMG by both newborn and adult tubules reached a steady state and achieved a distribution ratio (DR) of 4.9 and 6.5, respectively; decreased DR's at higher substrate concentrations suggest concentration-dependent uptake. Lineweaver-Burk analysis of the 5 min calculated velocities of HMG uptake by newborn and adult tubules indicate a single transport system with the same apparent Km of 0.2 mM in both age groups. The Vmax in adult rats was twofold greater than in newborn (0.95 versus 0.44 mM/1/5 min). The carrier system for HMG is assumed to be distinct from those of amino acids and sugars because tubule uptake of HMG is not affected by the presence of alpha-NH2-isobutyric acid and alpha-methyl-D-glucoside. Sodium maleate and acetoacetate significantly decreased HMG uptake in tubules of both age groups. HMG uptake by isolated renal brush border membrane vesicles from adult rats suggests that uptake is both carrier-mediated and Na+-dependent.
2.[Physiological study and taxonomy of Alcaligenes species: A denitrificans, A. odorans and A faecalis].
Pichinoty F;Véron M;Mandel M;Durand M;Job C;Garcia JL Can J Microbiol. 1978 Jun;24(6):743-53.
We have studied 43 strains of the species Alcaligenes dentrificans, A. odorans, and A. faecalis. Twenty-five of them were isolated by enrichment culture on minimal medium containing an organic acid (L-malate, succinate, tartrate, adipate, or itaconate) and N2O as a respiratory electron acceptor. These constitute a single phenon with the A. dentrificans strain type and 9 other strains isolated from clinical specimens. However, strain 4 differs from the other 34 strains in 12 nutritional characters, in its ability to effect a meta cleavage of diphenols, and by the absence of tetrathionate reductase. The percentages of G + C are the following: strains isolated from soil, 66.4 +/- 1.1; collection strains, 67.0 +/- 1.3. The 5 strains of A. odorans differ from the 34 strains of A. denitrificans (not including strain 4) in their inability to denitrify nitrate and use D-saccharate, adipate, pimelate, suberate, beta-hydroxy-beta-methylglutarate meso-tartrate, azelate, and itaconate. Their percentage of G + C is much lower: 56.1 +/- 0.4. From the nutritional point of view the 3 strains of A. faecalis resemble A. dentrificans. However, they differ from the latter by their inability to grow anaerobically on NO3-, NO2-, N2O, and by a slightly lower percentage of G+ C: 64.
3.Role of melanin pigment in expression of Vibrio cholerae virulence factors.
Valeru SP;Rompikuntal PK;Ishikawa T;Vaitkevicius K;Sjöling A;Dolganov N;Zhu J;Schoolnik G;Wai SN Infect Immun. 2009 Mar;77(3):935-42. doi: 10.1128/IAI.00929-08. Epub 2008 Dec 22.
We identified the mutated gene locus in a pigment-overproducing Vibrio cholerae mutant of strain A1552. The deduced gene product is suggested to be an oxidoreductase based on partial homology to putative homogentisate 1,2-dioxygenase in Pseudomonas aeruginosa and Mesorhizobium loti, and we propose that the gene VC1345 in the V. cholerae genome be denoted hmgA in accordance with the nomenclature for other species. The hmgA::mini-Tn5 mutant showed a nonpigmented phenotype after complementation with a plasmid clone carrying the WT hmgA(+) locus. Microarray transcription analysis revealed that expression of hmgA and the neighboring genes encoding a postulated two-component sensor system was growth phase dependent. Results from quantitative reverse transcription-PCR analysis showed that hmgA operon expression was reduced in the rpoS mutant, but pigment production by the WT V. cholerae or the hmgA mutant was not detectably influenced by the stationary-phase regulator RpoS. The pigmented mutant showed increased UV resistance in comparison with the WT strain. Interestingly, the pigment-producing mutant expressed more toxin-coregulated pilus and cholera toxin than WT V. cholerae. Moreover, the hmgA mutant showed a fivefold increase in the ability to colonize the intestines of infant mice.
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