Medetomidine - CAS 86347-14-0
Catalog number:
86347-14-0
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C13H16N2
Molecular Weight:
200.28
COA:
Inquire
Targets:
Adrenergic Receptor
Description:
Medetomidine is a potent, highly selective α2-adrenoceptor agonist, which Ki values are 1.08 and 1750 nM for α2- and α1-adrenoceptors respectively. It is often used as the hydrochloride salt, medetomidine hydrochloride. It is a racemic mixture of two stereoisomers and dexmedetomidine is the isomer with more useful effects. It is a synthetic drug used as both a surgical anesthetic and analgesic. It is used in veterinary medicine for its analgesic and sedative properties. It inhibits twitch response in electrically stimulated mouse vas deferens. It can be administered as an intravenous drug solution with sterile water. It has been developed by Orion Pharma. It is currently approved for dogs in the United States, and distributed in the United States by Pfizer Animal Health and by Novartis Animal Health in Canada under the product name Domitor. It is distributed by the Swedish company I-Tech AB under the product name Selektope for use as an antifouling substance in marine paints. It also can be used as an antifouling substance in marine paint and mainly effective against barnacles.
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Purity:
>98 %
Appearance:
Solid powder
Synonyms:
4-[1-(2,3-Dimethylphenyl)ethyl]-1H-imidazole;( -)-4-(alpha,2,3-Trimethylbenzyl)imidazole;(Rs)-4-(alpha,2,3-trimethylbenzyl)imidazol;1H-Imidazole, 4-(1-(2,3-dimethylphenyl)ethyl)-;5-[1-(2,3-dimethylphenyl)ethyl]-1H-imidazole
Solubility:
10 mM in DMSO
Storage:
-20°C Freezer
MSDS:
Inquire
Application:
Medetomidine is used in veterinary medicine for its analgesic and sedative properties. It also can be used as an antifouling substance in marine paint and mainly effective against barnacles.
Quality Standard:
In-house standard
Shelf Life:
2 month in rt, long time
Quantity:
Grams-Kilos
Boiling Point:
381.9±11.0 °C | Condition: Press: 760 Torr
Density:
1.053±0.06 g/cm3 | Condition: Temp: 20 °C Press: 760 Torr
InChIKey:
CUHVIMMYOGQXCV-UHFFFAOYSA-N
InChI:
InChI=1S/C13H16N2/c1-9-5-4-6-12(10(9)2)11(3)13-7-14-8-15-13/h4-8,11H,1-3H3,(H,14,15)
Canonical SMILES:
CC1=C(C(=CC=C1)C(C)C2=CN=CN2)C
Current Developer:
Medetomidine was developed by Orion Pharma.
1.Effects of a medetomidine-ketamine combination on Schirmer tear test I results of clinically normal cats.
Di Pietro S, Macrì F, Bonarrigo T, Giudice E, Palumbo Piccionello A, Pugliese A. Am J Vet Res. 2016 Mar;77(3):310-4. doi: 10.2460/ajvr.77.3.310.
OBJECTIVE To evaluate the effects of a medetomidine-ketamine combination on tear production of clinically normal cats by use of the Schirmer tear test (STT) 1 before and during anesthesia and after reversal of medetomidine with atipamezole. ANIMALS 40 client-owned crossbred domestic shorthair cats (23 males and 17 females; age range, 6 to 24 months). PROCEDURES A complete physical examination, CBC, and ophthalmic examination were performed on each cat. Cats with no abnormalities on physical and ophthalmic examinations were included in the study. Cats were allocated into 2 groups: a control group (n = 10 cats) anesthetized by administration of a combination of medetomidine hydrochloride (80 μg/kg) and ketamine hydrochloride (5 mg/kg), and an experimental group (30) anesthetized with the medetomidine-ketamine combination and reversal by administration of atipamezole. Tear production of both eyes of each cat was measured by use of the STT I before anesthesia, 15 minutes after the beginning of anesthesia, and 15 minutes after administration of atipamezole.
2.EFFICACY AND SAFETY OF A MEDETOMIDINE-AZAPERONE-ALFAXALONE COMBINATION IN CAPTIVE WHITE-TAILED DEER (ODOCOILEUS VIRGINIANUS).
Pon K, Caulkett N, Woodbury M. J Zoo Wildl Med. 2016 Mar;47(1):29-37. doi: 10.1638/2015-0121.1.
Alfaxalone is a neurosteroid that interacts with gamma-aminobutyric type A receptors to produce central nervous system depression and muscle relaxation. The effects of alfaxalone vary from sedation to general anesthesia. Alfaxalone is synergistic with other tranquilizers and sedatives and therefore has the potential to improve existing alpha-2 adrenergic agonist-based combinations used for wildlife immobilization. The objective of this study was to determine the efficacy and cardiopulmonary effects of a medetomidine-azaperone-alfaxalone (MAA) combination in captive white-tailed deer (Odocoileus virginianus). Eight captive white-tailed deer were restrained in a drop-floor chute; hand injected i.m. with 0.15 mg/kg medetomidine, 0.2 mg/kg azaperone, and 0.5 mg/kg alfaxalone; and released into a small enclosure for observation. The deer were maintained in lateral recumbency for a total time from postinjection (PI) of the drug of 60 min. At 60 min PI, atipamezole was administered i.
3.THIAFENTANIL-AZAPERONE-XYLAZINE AND CARFENTANIL-XYLAZINE IMMOBILIZATIONS OF FREE-RANGING CARIBOU (RANGIFER TARANDUS GRANTI) IN ALASKA, USA.
Lian M1,2, Beckmen KB2, Bentzen TW2, Demma DJ3, Arnemo JM1,4. J Wildl Dis. 2016 Mar 11. [Epub ahead of print]
Carfentanil-xylazine (CX) has been the primary drug combination used for immobilizing free-ranging ungulates in Alaska, USA since 1986. We investigated the efficacy of a potential new drug of choice, thiafentanil (Investigational New Animal Drug A-3080). Captive trials indicated that thiafentanil-azaperone-medetomidine could provide good levels of immobilization. However, field trials conducted in October 2013 on free-ranging caribou ( Rangifer tarandus granti) calves showed the combination too potent, causing three respiratory arrests and one mortality. The protocol was revised to thiafentanil-azaperone-xylazine (TAX), with good results. The induction time was not significantly different between the two combinations. However, the recovery time was significantly shorter for the TAX group than for the CX group. A physiologic evaluation was performed on 12 animals immobilized on CX and 15 animals on TAX. Arterial blood was collected after induction and again after 10 min of intranasal oxygen supplements (1 L/min).
4.Evaluation and optimisation of propofol pharmacokinetic parameters in cats for target-controlled infusion.
Cattai A1, Pilla T2, Cagnardi P3, Zonca A3, Franci P1. Vet Rec. 2016 Apr 4. pii: vetrec-2015-103560. doi: 10.1136/vr.103560. [Epub ahead of print]
The aim of this study was to develop and evaluate a pharmacokinetic model-driven infusion of propofol in premedicated cats. In a first step, propofol (10 mg/kg) was administered intravenously over 60 seconds to induce anaesthesia for the elective neutering of seven healthy cats, premedicated intramuscularly with 0.3 mg/kg methadone, 0.01 mg/kg medetomidine and 2 mg/kg ketamine. Venous blood samples were collected over 240 minutes, and propofol concentrations were measured via a validated high-performance liquid chromatography assay. Selected pharmacokinetic parameters, determined by a three-compartment open linear model, were entered into a computer-controlled infusion pump (target-controlled infusion-1 (TCI-1)). In a second step, TCI-1 was used to induce and maintain general anaesthesia in nine cats undergoing neutering. Predicted and measured plasma concentrations of propofol were compared at specific time points. In a third step, the pharmacokinetic parameters were modified according to the results from the use of TCI-1 and were evaluated again in six cats.
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CAS 86347-14-0 Medetomidine

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