|Description||Meclinertant, a chloroquinolin derivative, has been found to be a Neurotensin receptor antagonist that could be probably effective against schizophrenia and some sorts of drug addiction at some extent. It has been already discontinued by sanofi-aventis for Small cell lung cancer. IC50: 15.3 and 20.4 nM for NTS1 and NTS2 respectively.|
|Synonyms||Meclinertant; SR 48692; SR-48692; Reminertant; SR48692|
|Storage||Store in a cool and dry place and at 0 - 4 °C for short term (days to weeks) or -20 °C for long term (months to years).|
|Quality Standard||In-house standard|
Neurotensin, a gut tridecapeptide with many central and peripheral functions, acts as a potent cellular mitogen for various colorectal and pancreatic cancers wh...
Meclinertant, a chloroquinolin derivative, has been found to be a Neurotensin receptor antagonist that could be probably effective against schizophrenia and som...
Medicinal chemistry optimization of MLS-0233108 led to ML314, the most potent molecule in this second series that exhibited full agonist behavior (100 %) on NTR...