|Description||Meclinertant, a chloroquinolin derivative, has been found to be a Neurotensin receptor antagonist that could be probably effective against schizophrenia and some sorts of drug addiction at some extent. It has been already discontinued by sanofi-aventis for Small cell lung cancer. IC50: 15.3 and 20.4 nM for NTS1 and NTS2 respectively.|
|Synonyms||Meclinertant; SR 48692; SR-48692; Reminertant; SR48692|
|Storage||Store in a cool and dry place and at 0 - 4 °C for short term (days to weeks) or -20 °C for long term (months to years).|
|Quality Standard||In-house standard|
Medicinal chemistry optimization of MLS-0233108 led to ML314, the most potent molecule in this second series that exhibited full agonist behavior (100 %) on NTR...
Neurotensin, a gut tridecapeptide with many central and peripheral functions, acts as a potent cellular mitogen for various colorectal and pancreatic cancers wh...
Meclinertant, a chloroquinolin derivative, has been found to be a Neurotensin receptor antagonist that could be probably effective against schizophrenia and som...
Dilept is an antagonist of neurotensin (NT) and dopamine (DA) receptor used to mitigate positive and negative symptoms of schizophrenia.