MDL 72527 - CAS 93565-01-6
Category: Inhibitor
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Molecular Formula:
Molecular Weight:
MDL 72527 is a polyamine oxidase inhibitor. It can block the production of H2O2 and increase the cells survival. MDL 72527 shows anticancer and neuroprotective activity in vivo.
≥95% by HPLC
MDL 72527; MDL72527; MDL-72527; N1,N4-Di-2,3-butadienyl-1,4-butanediamine dihydrochloride
Canonical SMILES:
1.A small molecule polyamine oxidase inhibitor blocks androgen-induced oxidative stress and delays prostate cancer progression in the transgenic adenocarcinoma of the mouse prostate model.
Basu HS;Thompson TA;Church DR;Clower CC;Mehraein-Ghomi F;Amlong CA;Martin CT;Woster PM;Lindstrom MJ;Wilding G Cancer Res. 2009 Oct 1;69(19):7689-95. doi: 10.1158/0008-5472.CAN-08-2472. Epub 2009 Sep 22.
High levels of reactive oxygen species (ROS) present in human prostate epithelia are an important etiologic factor in prostate cancer (CaP) occurrence, recurrence, and progression. Androgen induces ROS production in the prostate by a yet unknown mechanism. Here, to the best of our knowledge, we report for the first time that androgen induces an overexpression of spermidine/spermine N1-acetyltransferase, the rate-limiting enzyme in the polyamine oxidation pathway. As prostatic epithelia produce a large excess of polyamines, the androgen-induced polyamine oxidation that produces H2O2 could be a major reason for the high ROS levels in the prostate epithelia. A small molecule polyamine oxidase inhibitor N,N'-butanedienyl butanediamine (MDL 72,527 or CPC-200) effectively blocks androgen-induced ROS production in human CaP cells, as well as significantly delays CaP progression and death in animals developing spontaneous CaP. These data show that polyamine oxidation is not only a major pathway for ROS production in prostate, but inhibiting this pathway also successfully delays CaP progression.
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CAS 93565-01-6 MDL 72527

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