MDL 11939 - CAS 107703-78-6
Category: Inhibitor
Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Molecular Formula:
C20H25NO
Molecular Weight:
295.42
COA:
Inquire
Targets:
5-HT Receptor
Description:
MDL 11939 is a selective 5-HT2A receptor antagonist. MDL 11939 has anti-arrhythmic activity in anesthetized dogs following myocardial infarction.
Purity:
≥99% by HPLC
Synonyms:
Glemanserin; MDL 11,939; Mdl 11939; α-Phenyl-1-(2-phenylethyl)-4-piperidinemethanol
MSDS:
Inquire
InChIKey:
AXNGJCOYCMDPQG-UHFFFAOYSA-N
InChI:
InChI=1S/C20H25NO/c22-20(18-9-5-2-6-10-18)19-12-15-21(16-13-19)14-11-17-7-3-1-4-8-17/h1-10,19-20,22H,11-16H2
Canonical SMILES:
C1CN(CCC1C(C2=CC=CC=C2)O)CCC3=CC=CC=C3
1.Methylenedioxymethamphetamine-induced hyperthermia and neurotoxicity are independently mediated by 5-HT2 receptors.
Schmidt CJ;Black CK;Abbate GM;Taylor VL Brain Res. 1990 Oct 8;529(1-2):85-90.
Methylenedioxymethamphetamine (MDMA) produced a significant hyperthermia in rats which was antagonized in a competitive manner by the selective 5-HT2 antagonist, MDL 11,939. The 5-HT antagonist also blocked MDMA-induced neurotoxicity as assessed by the decline in regional 5-HT concentrations observed 1 week later. These two effects of MDL 11,939 were dissociated at higher doses of MDMA where the antagonist still provided virtually complete protection against the neurochemical deficits but only partially attenuated the hyperthermic response. In contrast to the effect of the 5-HT2 antagonist, haloperidol did not alter MDMA-induced hyperthermia but did antagonize its long-term neurochemical effects. Similarly, coadministration of the selective 5-HT uptake inhibitor, MDL 27,777, did not affect the hyperthermia produced by a high dose of MDMA but completely prevented the depletion of 5-HT. When the MDMA-induced hyperthermia was prevented by temporarily maintaining animals at reduced ambient temperature, the neurochemical changes normally observed 1 week later were also blocked. Although these results demonstrate that the drugs tested do not antagonize MDMA-induced neurotoxicity by interfering with its effect on body temperature, they do indicate that MDMA-induced hyperthermia may contribute to the development of the drug's long-term neurochemical effects.
2.Effects of serotonin 5-HT(2A/2C) antagonists on associative learning in the rabbit.
Welsh SE;Romano AG;Harvey JA Psychopharmacology (Berl). 1998 May;137(2):157-63.
The 5-HT(2A/2C) receptor antagonist, ritanserin, was reported to retard the acquisition of conditioned responses (CRs) during classical conditioning of the rabbit's nictitating membrane (NM) response. The present study compared the effects of ritanserin on acquisition of CRs to a tone conditioned stimulus (CS) with that of the 5-HT(2A/2C) receptor antagonist, LY-53,857 and the 5-HT2A selective antagonist, MDL-11,939. All three drugs were injected at equimolar doses of 0.067, 0.67 and 6.7 micromol/kg, SC, 1 h before behavioral testing. Ritanserin and MDL-11,939 retarded CR acquisition to a tone CS, while LY-53,857 had no effect. Control experiments demonstrated that ritanserin (1 micromol/kg), MDL-11,939 (1 micromol/kg) and LY-53,857 (2 micromol/kg) had no effect on baseline responding or non-associative responding to the CS. However, both ritanserin and MDL-11,939 impaired the performance of the unconditioned NM reflex, as measured by a decrease in UR amplitudes on US alone trials, while LY-53,857 had no effect. In previously trained animals, ritanserin robustly impaired the performance of CRs, as measured by a reduced ability of the CS to elicit CRs, while the effects of LY-53,857 and MDL-11,939 were marginal.
3.5HT2 receptors mediate the effects of stress on the activity of periventricular hypophysial dopaminergic neurons and the secretion of alpha-melanocyte-stimulating hormone.
Goudreau JL;Manzanares J;Lookingland KJ;Moore KE J Pharmacol Exp Ther. 1993 Apr;265(1):303-7.
The roles of 5-hydroxytryptaminergic (5HT) neurons and receptor subtypes in mediating the effects of stress on the activity of periventricular hypophysial dopaminergic (PHDA) neurons and the secretion of alpha-melanocyte-stimulating hormone (alpha MSH) were examined in female rats. Periventricular hypophysial dopaminergic neuronal activity was estimated by measuring concentrations of 3,4-dihydroxyphenylacetic acid in the intermediate lobe of the pituitary. Brief exposure to diethylether followed by 30 min of supine restraint decreased intermediate lobe 3,4-dihydroxyphenylacetic acid concentrations and increased plasma concentrations of alpha MSH. These stress-induced effects were not observed in animals in which 5HT neurons had been previously destroyed by 5,7-dihydroxytryptamine or inhibited by the administration of the 5HT1A receptor agonist 8-hydroxy-2-(di-n-propyl-amino)-tetralin. Pretreatment of rats with the 5HT2 receptor antagonist MDL-11,939 blocked the inhibitory effects of stress on intermediate lobe 3,4-dihydroxyphenylacetic acid concentrations and the corresponding increase in plasma alpha MSH concentrations, whereas the 5HT3 receptor antagonist ondansetron was without effect.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related 5-HT Receptor Products


CAS 96850-13-4 Indatraline hydrochloride

Indatraline hydrochloride
(CAS: 96850-13-4)

Indatraline hydrochloride is the hydrobromide salt of indatraline, which is a potent monoamine uptake inhibitor. It inhibits the synaptosomal uptake of noradren...

CAS 192927-92-7 LY310762

LY310762
(CAS: 192927-92-7)

LY310762 has a higher affinity for the guinea pig 5-HT1D receptor than for the 5-HT1B receptor. LY310762 potentiates the potassium-induced [3H]5-HT outflow from...

CAS 1197333-95-1 RO 04-6790 hydrochloride

RO 04-6790 hydrochloride
(CAS: 1197333-95-1)

RO 04-6790 hydrochloride is a potent and selective serotonin 5-HT6 receptor antagonist.

CAS 40796-97-2 MDL 72222

MDL 72222
(CAS: 40796-97-2)

MDL 72222 is a 5-HT3 receptor antagonist.

CAS 83366-66-9 NEFAZODONE

NEFAZODONE
(CAS: 83366-66-9)

Nefazodone is a selective serotonin 5-HT2 receptor antagonist. It is an antidepressant under the development of Bristol-Myers Squibb. Its sale was discontinued ...

CAS 102908-60-1 MDL 73005EF hydrochloride

MDL 73005EF hydrochloride
(CAS: 102908-60-1)

MDL 73005EF hydrochloride is a 5-HT1A receptor antagonist.

CAS 133920-70-4 FK 960

FK 960
(CAS: 133920-70-4)

FK 960 is a somatostatin receptor agonist and a 5-HT agonist activating both serotonin and somatostatin production as a cognitive enhancer. The phase II clinica...

CAS 350992-13-1 Bifeprunox mesylate

Bifeprunox mesylate
(CAS: 350992-13-1)

Bifeprunox mesylate is a dopamine D2 and 5-HT1A partial agonist developed as an atypical antipsychotic for the treatment of schizophrenia and other psychotic in...

Chemical Structure

CAS 107703-78-6 MDL 11939

Quick Inquiry

Verification code

Featured Items