Mdivi-1 - CAS 338967-87-6
Catalog number: 338967-87-6
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
Molecular Weight:
Mdivi-1 is a selective cell-permeable inhibitor of mitochondrial division DRP1 (dynamin-related GTPase) and mitochondrial division Dynamin I (Dnm1) with IC50 of 1-10 μM.
Publictions citing BOC Sciences Products
  • >> More
1.Mdivi-1 Protects Epileptic Hippocampal Neurons from Apoptosis via Inhibiting Oxidative Stress and Endoplasmic Reticulum Stress in Vitro.
Xie N1, Wang C2, Wu C1, Cheng X1, Gao Y1, Zhang H1, Zhang Y1, Lian Y3. Neurochem Res. 2016 Jan 22. [Epub ahead of print]
Mitochondrial division inhibitor 1 (mdivi-1), a selective inhibitor of the mitochondrial fission protein dynamin-related protein 1, has been proposed to have a neuroprotective effect on hippocampal neurons in animal models of epilepsy. However, the effect of mdivi-1 on epileptic neuronal death in vitro remains unknown. Therefore, we investigated the effect of mdivi-1 and the underlying mechanisms in the hippocampal neuronal culture (HNC) model of acquired epilepsy (AE) in vitro. We found that mitochondrial fission was increased in the HNC model of AE and inhibition of mitochondrial fission by mdivi-1 significantly decreased neuronal apoptosis induced by AE. In addition, mdivi-1 pretreatment significantly attenuated oxidative stress induced by AE characterized by decrease of reactive oxygen species (ROS) production and malondialdehyde level and by increase of superoxide dismutase activity. Moreover, mdivi-1 pretreatment significantly decreased endoplasmic reticulum (ER) stress markers glucose-regulated protein 78, C/EBP homologous protein expression and caspase-3 activation.
2.The mitochondrial division inhibitor Mdivi-1 rescues mammalian neurons from anesthetic-induced cytotoxicity.
Xu F1,2, Armstrong R3, Urrego D3, Qazzaz M3, Pehar M4, Armstrong JN4, Shutt T5, Syed N6,7. Mol Brain. 2016 Mar 24;9:35. doi: 10.1186/s13041-016-0210-x.
BACKGROUND: Concerns have risen regarding the potential side effects of clinical exposure of the pediatric population to inhalational anesthetics, and how they might impact cognitive, learning, and memory functions. However, neither the mechanisms of anesthetic cytotoxicity, nor potential protective strategies, have yet been fully explored. In this study, we examined whether two of the most commonly used inhalational anesthetics, sevoflurane and desflurane, affect neuronal viability and synaptic network assembly between cultured rat cortical neurons.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Dynamin Products

CAS 1120-02-1 OctMAB

(CAS: 1120-02-1)

OctMAB is a dynamin inhibitor with IC50 value of 1.9 μM for dynamin I. It can also inhibit receptor-mediated endocytosis.

CAS 251634-21-6 Dynamin inhibitory peptide

Dynamin inhibitory peptide
(CAS: 251634-21-6)

Has been found to be a peptide inhibitor of the GTPase dynamin and competitively blocks binding of dynamin to amphiphysin thus prevents endocytosis when adminis...

CAS 1128165-88-7 Dynole 34-2

Dynole 34-2
(CAS: 1128165-88-7)

Dynole 34-2 is a dynamin I inhibitor with IC50 value of 1.3 μM. It also inhibits receptor-mediated endocytosis (RME) with IC50 value of 5.0 μM.

CAS 338967-87-6 Mdivi-1

(CAS: 338967-87-6)

Mdivi-1 is a selective cell-permeable inhibitor of mitochondrial division DRP1 (dynamin-related GTPase) and mitochondrial division Dynamin I (Dnm1) with IC50 of...

CAS 304448-55-3 Dynasore

(CAS: 304448-55-3)

Dynasore is a cell-permeable and noncompetitive inhibitor of the GTPase activity of dynamin with IC50 value of 15 µM.

CAS 251939-41-0 D15

(CAS: 251939-41-0)

D15 is an endocytosis inhibitor, blocking the interaction of dynamin with amphiphysin 1 and 2. It impairs AMPA receptor cycling and blocks DHPG-induced long ter...

Chemical Structure

CAS 338967-87-6 Mdivi-1

Quick Inquiry

Verification code

Featured Items