|Description||(±)-McN 5652 is a potent, orally active 5-HT uptake inhibitor. McN-5652 is characterized by exceptionally high potency as an inhibitor of the uptake of serotonin by rat brain synaptosomes in vitro (Ki approximately 0.6 nM) and ex vivo (ED50 approximately 2 mg/kg p.o.). (±)-McN 5652 is a potent, selective inhibitor of serotonin reuptake in mammalian brain. It potently potentiates 5-HT-induced effects in vivo following oral administration. Its biological activity resides predominantly in the (+)-enantiomer.|
|Purity||≥98% by HPLC|
|Synonyms||(±)-McN 5652; (±)-McN5652; (±)-McN-5652; (6R,10bS)-rel-1,2,3,5,6,10b-Hexahydro-6-[4-(methylthio)phenyl]-pyrrolo[2,1-a]isoquinoline|
|Storage||Store in a cool and dry place (or refer to the Certificate of Analysis).|
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