Mc-MMAF - CAS 863971-19-1
Catalog number: B0238-477041
Category: ADCs
Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Molecular Formula:
C49H76N6O11
Molecular Weight:
925.18
COA:
Inquire
Tag:
ADCs Cytotoxin with Linkers
Description:
Mc-MMAF is a protective group-conjugated MMAF, MMAF is an antitubulin agent that inhibit cell division by blocking the polymerization of tubulin and it has lower cytotoxic activity than MMAE.
Ordering Information
Catalog Number Size Price Stock Quantity
B0238-477041 1 mg $499 In stock
Bulk Inquiry
Purity:
≥98%
Appearance:
Soild powder
Synonyms:
SGD-1269; SGD 1269; SGD1269; mc-MMAF; mcMMAF; L4-MMAF; Maleimidocaproyl-MMAF; Maleimidocaproyl monomethylauristatin F; Mafodotin.((2R,3R)-3-((S)-1-((3R,4S,5S)-4-((S)-2-((S)-2-(6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-N-methylhexanamido)-3-methylbutanamido)-N,3-dimethylbutanamido)-3-methoxy-5-methylheptanoyl)pyrrolidin-2-yl)-3-methoxy-2-methylpropanoyl)-L-phenylalanine
MSDS:
Inquire
InChIKey:
ORFNVPGICPYLJV-YTVPMEHESA-N
InChI:
InChI=1S/C49H76N6O11/c1-12-32(6)44(37(65-10)29-41(59)54-27-19-22-36(54)45(66-11)33(7)46(60)50-35(49(63)64)28-34-20-15-13-16-21-34)53(9)48(62)42(30(2)3)51-47(61)43(31(4)5)52(8)38(56)23-17-14-18-26-55-39(57)24-25-40(55)58/h13,15-16,20-21,24-25,30-33,35-37,42-45H,12,14,17-19,22-23,26-29H2,1-11H3,(H,50,60)(H,51,61)(H,63,64)/t32-,33+,35-,36-,37+,42-,43-,44-,45+/m0/s1
Canonical SMILES:
O=C(O)[C@H](CC1=CC=CC=C1)NC([C@H](C)[C@H]([C@H]2N(C(C[C@@H](OC)[C@@H](N(C)C([C@@H](NC([C@@H](N(C)C(CCCCCN3C(C=CC3=O)=O)=O)C(C)C)=O)C(C)C)=O)[C@@H](C)CC)=O)CCC2)OC)=O
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related ADCs Cytotoxin with Linkers Products


CAS 151038-96-9 DOXO-EMCH

DOXO-EMCH
(CAS: 151038-96-9)

INNO-206 is an albumin-binding prodrug of doxorubicin, which is released from albumin under acidic conditions.

DM4-SMCC

DM4 with a reactive linker SMCC, which can react with antibody to make antibody drug conjugate. DM4 can bind to tubulin at or near the vinblastine-binding site.

CAS 1401963-15-2 Mc-MMAD

Mc-MMAD
(CAS: 1401963-15-2)

Monomethyl auristatin D (MMAD), a potent tubulin inhibitor, is a toxin payload in antibody drug conjugate; Mc-MMAD is a protective group (maleimidocaproyl) -con...

Fmoc-VC-PAB-MMAE
(CAS: 1350456-56-2)

Fmoc-Val-Cit-PAB-MMAE is an antibody drug conjugate contained Fmoc-Val-Cit-PAB and MMAE and probably have antineoplastic activity.

CAS 863971-24-8 Mc-MMAE

Mc-MMAE
(CAS: 863971-24-8)

Mc-MMAE is a protective group conjugated MMAE, MMAE inhibits tubulin polymerization so that it inhibits cell division.

CAS 1401963-17-4 Vc-MMAD

Vc-MMAD
(CAS: 1401963-17-4)

Vc-MMAD consists the ADCs linker(Val-Cit) and potent tubulin inhibitor (MMAD), Vc-MMAD is an antibody drug conjugate.

sulfo-SPDB-DM4

DM4 with a reactive linker sulfo-SPDB, which can react with antibody to make antibody drug conjugate. DM4 can bind to tubulin at or near the vinblastine-binding...

CAS 1342820-51-2 MC-Val-Ala-PBD

MC-Val-Ala-PBD
(CAS: 1342820-51-2)

MC-Val-Ala-PBD is a protective group conjugated PBD, PBD bind in the minor groove of DNA.

CAS 138148-68-2 DM1-SMe

DM1-SMe
(CAS: 138148-68-2)

DM1-SMe is a potent maytansinoid microtubular inhibitor and an unconjugated DM1 as a mixed disulfide with thiomethane to cap its sulfhydryl group. DM1-SMe can b...

CAS 1361644-26-9 INNO-206

INNO-206
(CAS: 1361644-26-9)

INNO-206 (Aldoxorubicin) is the 6-maleimidocaproyl hydrazone derivative prodrug of the anthracycline antibiotic doxorubicin (DOXO-EMCH) with antineoplastic acti...

CAS 1415329-13-3 Vat-Cit-PAB-MMAD

Vat-Cit-PAB-MMAD
(CAS: 1415329-13-3)

Vat-Cit-PAB-MMAD is a protective group conjugated MMAD, MMAD is a toxin payload in antibody drug conjugate.

CAS 1018448-65-1 Trastuzumab emtansine

Trastuzumab emtansine
(CAS: 1018448-65-1)

Trastuzumab emtansine is an antibody-drug conjugate (ADC) consisting of the recombinant anti-epidermal growth factor receptor 2 (HER2) monoclonal antibody trast...

CAS 863971-19-1 Mc-MMAF

Mc-MMAF
(CAS: 863971-19-1)

Mc-MMAF is a protective group-conjugated MMAF, MMAF is an antitubulin agent that inhibit cell division by blocking the polymerization of tubulin and it has lowe...

MC-Val-Cit-PAB-MMAF
(CAS: 863971-17-9)

MC-Val-Cit-PAB-MMAF is a potent tubulin inhibitor (MMAF), Val-Cit-PAB-MMAF is an antibody drug conjugate.

CAS 452072-20-7 DM1-SPP

DM1-SPP
(CAS: 452072-20-7)

DM1 with a reactive linker SPP, which can react with antibody to make antibody drug conjugate, as a potent EGFR inhibitor and it overcomes resistant to EGFR.

Val-Cit-PAB-MMAE
(CAS: 644981-35-1)

Val-Cit-PAB-MMAE is a potent tubulin inhibitor (MMAE), Val-Cit-PAB-MMAE is an antibody drug conjugate.

DM4-SPDP

DM4 with a reactive linker SPDP, which can react with antibody to make antibody drug conjugate. DM4 can bind to tubulin at or near the vinblastine-binding site.

CAS 646502-53-6 MC-Val-Cit-PAB-MMAE

MC-Val-Cit-PAB-MMAE
(CAS: 646502-53-6)

MC-Val-Cit-PAB-MMAE is a potent tubulin inhibitor (MMAE), Val-Cit-PAB-MMAE is an antibody drug conjugate.

CAS 796073-70-6 DM3-SMe

DM3-SMe
(CAS: 796073-70-6)

DM3-SMe can be readily conjugate to the SH group of an antibody to form antibody-drug conjugate (ADC). .

BA-3011

BA-3011 is a novel conditionally active biologic AXL-targeted antibody-drug conjugate used to treat solid tumor. The CAB technology is aimed to improve the sele...

Chemical Structure

CAS 863971-19-1 Mc-MMAF

Quick Inquiry

Verification code

Featured Items