|Description||MC 969 is an analog of the calcemic drug 1α-hydroxyvitamin D3 (1α-OH-D3) in which carbons 25, 26, and 27 in the side chain are incorporated into a cyclopropane ring. Metabolites of MC 969 were generated in an in vitro human hepatocyte cell model, Hep 3B. The identity of the metabolites was established by comigration on HPLC with authentic standards, and by mass spectrometry of native and chemically modified metabolites Unequivocal identification of the 24-keto- and the two epimeric 24-alcohol metabolites is provided. No 25-hydroxylated metabolites were detected. In competition studies, MC 969 was able to inhibit 25-hydroxylation of tritiated vitamin D3 more effectively than 1α-OH-D3 itself, indicating that the vitamin D3-25-hydroxylase may be responsible for generation of one or more of the metabolites observed.|
Tacalcitol monohydrate is a VDR-like Receptor promotes normal bone development by regulating calcium. It modulates immunological and inflammatory processes and ...
1α, 24, 25-Trihydroxy VD2
1alpha, 24, 25-Trihydroxy VD2 is a vitamin D analog.
(24R)-MC 976 is a Vitamin D3 derivative.
LG190155 is a moderately potent VDR agonist.
Calcipotriol increased hCAP18 mRNA expression in IL-17/IL-22-stimulated keratinocytes. However, LL37 peptide in the culture supernatants was reduced by calcipot...
Calcitriol Impurities D
One of the impurities of Calcitriol, an active metabolite of VD3, could be a agonist of vitamin D receptor.
Calcifediol monohydrate is a prehormone that is produced in the liver by hydroxylation of vitamin D3 (cholecalciferol) by the enzyme cholecalciferol 25-hydroxyl...
(24S)-24,25-Dihydroxycholecalciferol is an inactive form of vitamin D3 which undergoes various levels of hydroxylation to form active vitamin D3 analogs.