MC 976 - CAS 129831-99-8
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Not Intended for Therapeutic Use. For research use only.
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MC 969 is an analog of the calcemic drug 1α-hydroxyvitamin D3 (1α-OH-D3) in which carbons 25, 26, and 27 in the side chain are incorporated into a cyclopropane ring. Metabolites of MC 969 were generated in an in vitro human hepatocyte cell model, Hep 3B. The identity of the metabolites was established by comigration on HPLC with authentic standards, and by mass spectrometry of native and chemically modified metabolites Unequivocal identification of the 24-keto- and the two epimeric 24-alcohol metabolites is provided. No 25-hydroxylated metabolites were detected. In competition studies, MC 969 was able to inhibit 25-hydroxylation of tritiated vitamin D3 more effectively than 1α-OH-D3 itself, indicating that the vitamin D3-25-hydroxylase may be responsible for generation of one or more of the metabolites observed.
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MC-976; MC976
1.A repeated cross-sectional study examining the school impact on child weight status.
Williams AJ1, Wyatt KM2, Williams CA3, Logan S4, Henley WE5. Prev Med. 2014 Jul;64:103-7. doi: 10.1016/j.ypmed.2014.04.003. Epub 2014 Apr 13.
OBJECTIVE: The aim of this study is to examine whether there is a differential impact of primary schools upon children's weight status.
2.Optimization in stent implantation by manual thrombus aspiration in ST-segment-elevation myocardial infarction: findings from the EXAMINATION trial.
Fernández-Rodríguez D1, Regueiro A1, Brugaletta S1, Martín-Yuste V1, Masotti M1, Cequier A1, Iñíguez A1, Serra A1, Hernández-Antolín R1, Mainar V1, Valgimigli M1, Tespili M1, den Heijer P1, Bethencourt A1, Vázquez N1, Serruys PW1, Sabaté M2; EXAMINATION i Circ Cardiovasc Interv. 2014 Jun;7(3):294-300. doi: 10.1161/CIRCINTERVENTIONS.113.000964. Epub 2014 May 27.
BACKGROUND: Manual thrombus aspiration (TA) is effective to reduce the thrombus burden during primary percutaneous coronary intervention for ST-elevation myocardial infarction. The objective of this study is to assess the impact of manual TA on stent implantation during primary percutaneous coronary intervention.
3.In-vivo measurement of muscle tension: dynamic properties of the MC sensor during isometric muscle contraction.
Đorđević S1, Tomažič S2, Narici M3, Pišot R4, Meglič A1. Sensors (Basel). 2014 Sep 25;14(9):17848-63. doi: 10.3390/s140917848.
Skeletal muscle is the largest tissue structure in our body and plays an essential role for producing motion through integrated action with bones, tendons, ligaments and joints, for stabilizing body position, for generation of heat through cell respiration and for blood glucose disposal. A key function of skeletal muscle is force generation. Non-invasive and selective measurement of muscle contraction force in the field and in clinical settings has always been challenging. The aim of our work has been to develop a sensor that can overcome these difficulties and therefore enable measurement of muscle force during different contraction conditions. In this study, we tested the mechanical properties of a "Muscle Contraction" (MC) sensor during isometric muscle contraction in different length/tension conditions. The MC sensor is attached so that it indents the skin overlying a muscle group and detects varying degrees of tension during muscular contraction.
4.High cumulative oxygen levels are associated with improved survival of children treated with mild therapeutic hypothermia after cardiac arrest.
van Zellem L1, de Jonge R2, van Rosmalen J3, Reiss I2, Tibboel D1, Buysse C4. Resuscitation. 2015 May;90:150-7. doi: 10.1016/j.resuscitation.2014.12.013. Epub 2015 Jan 6.
AIM: The aim of this study was to analyze the relationship between the partial pressure of arterial oxygen (PaO2) and in-hospital (IH) mortality in children after cardiac arrest (CA) using the conventional cutoff analysis, which was compared with the cumulative analysis, a new method in PaO2 analysis. Additionally, we analyzed this relationship for children with and without mild therapeutic hypothermia (MTH; 32-34 °C).
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