Maxacalcitol - CAS 103909-75-7
Catalog number: 103909-75-7
Category: Inhibitor
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Molecular Formula:
C26H42O4
Molecular Weight:
418.61
COA:
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Targets:
VD/VDR
Description:
Maxacalcitol is non-calcemic vitamin D3 analog and ligand of VDR-like receptors.
Purity:
>98%
Synonyms:
22-Oxacalcitriol
MSDS:
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InChIKey:
DTXXSJZBSTYZKE-ZDQKKZTESA-N
InChI:
InChI=1S/C26H42O4/c1-17-20(15-21(27)16-24(17)28)9-8-19-7-6-12-26(5)22(10-11-23(19)26)18(2)30-14-13-25(3,4)29/h8-9,18,21-24,27-29H,1,6-7,10-16H2,2-5H3/b19-8+,20-9-/t18-,21+,22+,23-,24-,26+/m0/s1
Canonical SMILES:
CC(C1CCC2C1(CCCC2=CC=C3CC(CC(C3=C)O)O)C)OCCC(C)(C)O
1.The Influence of Maxacalcitol, Vitamin D3 Analog, on Detrusor Overactivity in Conscious Rats.
Wróbel A1, Rechberger T2. Urology. 2016 Mar 23. pii: S0090-4295(16)00296-X. doi: 10.1016/j.urology.2016.03.008. [Epub ahead of print]
OBJECTIVES: To test the hypothesis that maxacalcitol, vitamin D3 analog, would ameliorate detrusor overactivity (DO) induced by retinyl acetate instillation; To test the outcome of the combined administration of maxacalcitol and the ROCK inhibitor -GSK 269962, amlodipine besylate or oxybutynin chloride in this model.
2.Vitamin d in the patients with chronic kidney disease: when, to whom and in which form.
Pavlovic D1, Katicic D1, Gulin T1, Josipovic J1. Mater Sociomed. 2015 Apr;27(2):122-4. doi: 10.5455/msm.2015.27.122-124. Epub 2015 Apr 5.
Alteration in vitamin D metabolism has a central role in the pathogenesis of secondary hyperparathyroidism (SHPT) and is also associated with increased cardiovascular morbidity and mortality in patients with chronic kidney disease (CKD). For more than sixty years, vitamin D, nutritional vitamin D (ergocalciferol, cholecalciferol or calcifediol) and nonselective vitamin D receptor (VDR) activators (calcitriol, alfacalcidol) have been used in the prevention and treatment of SHPT. In the last twenty years, selective VDR activators (paricalcitol, maxacalcitol) have been used to target SHPT. However, there are many open questions regarding use of nutritional vitamin D or VDR activators. The K/DOQI and KDIGO guidelines recommended testing for vitamin D insufficiency and deficiency in patients with CKD, but there is no consensus on the definition of vitamin D insufficiency in CKD. There are a many open questions, for example, regarding the optimal nutritional vitamin D type and the dose and co-administration of nutritional vitamin and VDR activators.
3.Effect of Vitamin D Receptor Activators on Glomerular Filtration Rate: A Meta-Analysis and Systematic Review.
Zhang Q1, Li M2, Zhang T3, Chen J4. PLoS One. 2016 Jan 26;11(1):e0147347. doi: 10.1371/journal.pone.0147347. eCollection 2016.
BACKGROUND: Vitamin D receptor activators (VDRAs) can protect against mineral bone disease, but they are reported to elevate serum creatinine (SCr) and may also reduce glomerular filtration rate (GFR).
4.The Vitamin D Receptor Activator Maxacalcitol Provides Cardioprotective Effects in Diabetes Mellitus.
Fujii H1, Nakai K2, Yonekura Y2, Kono K2, Goto S2, Hirata M3, Shinohara M4, Nishi S2, Fukagawa M2,5. Cardiovasc Drugs Ther. 2015 Dec;29(6):499-507.
PURPOSE: Recent reports showed a significant association between vitamin D levels and cardiovascular disease events and mortality. In the current study, we investigated the effect of the vitamin D receptor activator maxacalcitol (OCT) on cardiac damage in a rat model of type 2 diabetes.
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CAS 103909-75-7 Maxacalcitol

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