|Description||Mavoglurant is a structurally novel, non-competitive mGlu5 receptor antagonist (IC50=30 nM), as a a selective non-competitive antagonist.|
|Synonyms||AFQ-056; (3aR,4S,7aR)-Octahydro-4-hydroxy-4-[2-(3-methylphenyl)ethynyl]-1H-indole-1-carboxylic acid methyl ester; methyl (3aR,4S,7aR)-4-hydroxy-4-[2-(3-methylphenyl)ethynyl]-3,3a,5,6,7,7a-hexahydro-2H-indole-1-carboxylate|
|Solubility||Soluble in DMSO|
|Storage||Store at -20 °C|
|Application||A selective non-competitive antagonist|
|Quality Standard||Enterprise Standard|
|Shelf Life||As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly|
(±)-LY 395756 is a mixed mGlu2 agonist/mGlu3 antagonist.
YM 230888 is a selective mGlu1 antagonist (Ki = 13 nM) that inhibits mGlu1-mediated inositol phosphate production in rat cerebellar granule cells (IC50 = 13 nM)...
CPPG is the most potent group II/III mGluR antagonist displaying approximately 20-fold selectivity for group III over group II (IC50 = 2.2 and 46.2 nM, respecti...
Fenobam is a potent, selective, noncompetitive glutamate mGluR5 receptor antagonist. It displays inverse agonist properties. It blocks mGluR5 constitutive activ...
Z-Cyclopentyl-AP4 is a group III mGlu receptor agonist with higher potency at mGlu4 than mGlu8 (EC50 = 49 and 124 μM, respectively). Z-Cyclopentyl-AP4 selective...
JNJ 16259685, a pyrano-quinolin derivative, has been found to be a metabotropic glutamate receptor-1 antagonist.
LSN 2463359 is an allosteric modulator at the mGlu5 receptor with EC50 value of 24 nM. It is brain penetrant and can reverse learning deficits in a rat model of...
Spaglumic acid is the most abundant peptide neurotransmitter in the mammalian CNS. Spaglumic acid is a weak activator of NMDA receptors and a highly selective a...
VU 0155041 sodium salt
VU 0155041 sodium salt is a potent positive allosteric modulator at mGlu4 receptors (EC50 = 798 and 693 nM at human and rat mGlu4 receptors, respectively). VU 0...
LY 354740 is a selective group II mGlu receptors agonist with EC50 values are 5.1 and 24.3 nM at mGlu2 and mGlu3 receptors. It shows antianxiety and antiaddicti...
NPS 2390 is a Group I mGlu antagonist. NPS 2390 acts as a noncompetitive antagonist of mGluR1 and mGluR5 with IC50 values of 5.2 and 82 nM.
3-MATIDA is a potent metabotropic glutamate (mGlu1) receptor antagonist with IC50 value of 6.3 μM at rat mGlu1a. It displays ≥ 40-fold selectivity over other re...
BMT-145027 is a potent mGluR5 PAM without inherent agonist activity with an EC50 of 47 nM. BMT-145027 is a non-MPEP site PAM to demonstrate in vivo efficacy.
BAY 36-7620 elective mGlu1 receptor non-competitive antagonist (IC50 = 0.16 μM) with inverse agonist activity.
(RS)-3,5-DHPG is a group I metabotropic glutamate receptor (mGluR) agonist with selectivity for both mGlu1 and mGlu5. It is also acts as an antagonist at metabo...
DCB is an allosteric ligand for the metabotropic glutamate receptor mGlu5 that displays neutral modulation. It inhibits the modulation of mGlu5 by other alloste...
ADX-47273 is a drug used in scientific research which acts as a positive allosteric modulator selective for the metabotropic glutamate receptor subtype mGluR5.
VU 1545 is a metabotropic glutamate receptor 5 (mGlu5) positive allosteric modulator (EC50 = 9.6 nM, Ki = 156 nM at rat mGlu5).
(S)-HexylHIBO is a Group I mGlu receptor antagonist (Kb = 30 and 61 μM at mGlu1a and mGlu5a receptors, respectively).
L-AP4 is a selective group III metabotropic glutamate receptor (mGluR) agonist. It also acts as an agonist at the quisqualate-sensitized AP6 site in hippocampus...