|Description||Matrine((+)-Matrine) is an alkaloid found in plants from the Sophora family, which has a variety of pharmacological effects, including anti-cancer effects, and action as a kappa opioid receptor agonist.|
Cebranopadol is a novel first in class compounds with potent agonist activity on opioid receptor like -1(ORL-1) and the well established mu opioid receptor. lt ...
Deltorphin 2, an anion transporting peptid, is a selective peptide agonist for theδ opioid receptor.
LY 106737 is phenylpiperidine opioid receptor antagonist, but no detailed information has been published yet.
JNJ-20788560 is a delta opioid agonist analgesics. No recent reports of development identified for preclinical development in Inflammatory-pain in USA.
PZM21 is a potent Gi activator with exceptional selectivity for μOR (EC50= 1.8 nM) and minimal β-arrestin-2 recruitment.
6 α-naloxol, a human metabolite of naloxone, is an opioid antagonist.
Loperamide HCl is an opioid-receptor agonist with an ED50 of 0.15 mg/kg.
Papaverine is an opiate alkaloid isolated from the plant Papaver somniferum. It is used primarily in the treatment of visceral spasm, vasospasm. It is also used...
LY2795050, a κ-opioid Receptor antagonist, has been found to be effective in imaging KOR behaving as a PET tracer. IC50: 0.72 nM and 25.8 nM for κ-opioid Recept...
GSK-1521498 is a novel μ-Opioid receptor antagonist. It shows to attenuate reward-driven compulsive behaviours, such as stimulant drug seeking or binge eating i...
A 4-phenylpiperidine derivative, for the κ-opioid receptor.
Hemorphin-7, a hemorphin peptide with antinociceptive and antihypertensive effects, is an endogenous opioid peptide derived from the β-chain of hemoglobin. Hemo...
Naloxegol oxalate is a CYP3A4 enzyme inhibitor, is a peripherally-selective opioid antagonist, for the treatment of opioid-induced constipation.
Nalfurafine is a selective and centrally-penetrant κ-opioid receptor (KOR) agonist without significant activity on μ- and δ-opioid receptors. With antipruritic ...
Trimebutine is an opioid receptor agonist used as spasmolytic agent abdominal pain.
Trimebutine is an agonist of peripheral mu, kappa and delta opiate receptors, used as spasmolytic agent for treatment of both acute and chronic abdominal pain.
Alvimopan is a novel, oral, peripherally acting antagonist of the mu opioid receptor, which can help gastrointestinal recovery after surgery. Phase III IC50: Mu...
JTC-801 is a selective opioid receptor-like1 (ORL1) receptor antagonist with IC50 of 94 nM, weakly inhibits receptors δ, κ, and μ. It is an opioid analgesic dru...
BAN ORL 24 dihydrochloride
BAN ORL 24 dihydrochloride is a hydrochloride salt form of BAN ORL 24. BAN ORL 24, a spiro-isobenzofuran compound, has been found to be a NOP receptor antagonis...
Naltrexone significantly suppresses ethanol self-administration and prevents ethanol-induced increases in dialysate dopamine levels.