(+)-Matrine - CAS 519-02-8
Catalog number: B0084-070319
Category: Inhibitor
Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Molecular Formula:
C15H24N2O
Molecular Weight:
248.36
COA:
Inquire
Targets:
Opioid Receptor
Description:
Matrine((+)-Matrine) is an alkaloid found in plants from the Sophora family, which has a variety of pharmacological effects, including anti-cancer effects, and action as a kappa opioid receptor agonist.
Ordering Information
Catalog Number Size Price Stock Quantity
B0084-070319 2 g $299 In stock
Bulk Inquiry
Purity:
>98%
MSDS:
Inquire
InChIKey:
ZSBXGIUJOOQZMP-JLNYLFASSA-N
InChI:
InChI=1S/C15H24N2O/c18-14-7-1-6-13-12-5-3-9-16-8-2-4-11(15(12)16)10-17(13)14/h11-13,15H,1-10H2/t11-,12+,13+,15-/m0/s1
Canonical SMILES:
C1CC2C3CCCN4C3C(CCC4)CN2C(=O)C1
1.Antiparasitic effects of oxymatrine and matrine against Toxoplasma gondii in vitro and in vivo.
Zhang X1, Jin L1, Cui Z2, Zhang C1, Wu X3, Park H4, Quan H5, Jin C6. Exp Parasitol. 2016 Mar 16;165:95-102. doi: 10.1016/j.exppara.2016.03.020. [Epub ahead of print]
Toxoplasma gondii (T. gondii) is an important pathogen which can causes serious public health problems. Since the current therapeutic drugs for toxoplasmosis present serious host toxicity, research on effective and new substances of relatively low toxicity is urgently needed. This study was carried out to evaluate the anti-parasitic effect of oxymatrine (OM) and matrine (ME) against T. gondii in vitro and in vivo. In our study, the anti-T. gondii activities of ME and OM were evaluated in vitro using cell counting kit-8 assay, morphological observation and trypan blue exclusion assay. In vivo, mice were sacrificed four days post-infection and ascites were drawn out to determine the extent of tachyzoite proliferation. Viscera indexes and liver biochemical parameters, such as alanine aminotransferase (ALT), aspartate aminotransferase (AST), glutathione (GSH) and malondialdehyde (MDA), were examined to evaluate the toxicity of compounds to mice.
2.A Novel, Multi-Target Natural Drug Candidate, Matrine, Improves Cognitive Deficits in Alzheimer's Disease Transgenic Mice by Inhibiting Aβ Aggregation and Blocking the RAGE/Aβ Axis.
Cui L1, Cai Y2, Cheng W2, Liu G2, Zhao J2,3, Cao H4, Tao H2,3, Wang Y5, Yin M2, Liu T2, Liu Y2, Huang P2, Liu Z2, Li K1,6, Zhao B7. Mol Neurobiol. 2016 Feb 22. [Epub ahead of print]
The treatment of AD is a topic that has puzzled researchers for many years. Current mainstream theories still consider Aβ to be the most important target for the cure of AD. In this study, we attempted to explore multiple targets for AD treatments with the aim of identifying a qualified compound that could both inhibit the aggregation of Aβ and block the RAGE/Aβ axis. We believed that a compound that targets both Aβ and RAGE may be a feasible strategy for AD treatment. A novel and small natural compound, Matrine (Mat), was identified by high-throughput screening of the main components of traditional Chinese herbs used to treat dementia. Various experimental techniques were used to evaluate the effect of Mat on these two targets both in vitro and in AD mouse model. Mat could inhibit Aβ42-induced cytotoxicity and suppress the Aβ/RAGE signaling pathway in vitro. Additionally, the results of in vivo evaluations of the effects of Mat on the two targets were consistent with the results of our in vitro studies.
3.A Novel, Multi-Target Natural Drug Candidate, Matrine, Improves Cognitive Deficits in Alzheimer's Disease Transgenic Mice by Inhibiting Aβ Aggregation and Blocking the RAGE/Aβ Axis.
Cui L1, Cai Y2, Cheng W2, Liu G2, Zhao J2,3, Cao H4, Tao H2,3, Wang Y5, Yin M2, Liu T2, Liu Y2, Huang P2, Liu Z2, Li K1,6, Zhao B7. Mol Neurobiol. 2016 Feb 22. [Epub ahead of print]
The treatment of AD is a topic that has puzzled researchers for many years. Current mainstream theories still consider Aβ to be the most important target for the cure of AD. In this study, we attempted to explore multiple targets for AD treatments with the aim of identifying a qualified compound that could both inhibit the aggregation of Aβ and block the RAGE/Aβ axis. We believed that a compound that targets both Aβ and RAGE may be a feasible strategy for AD treatment. A novel and small natural compound, Matrine (Mat), was identified by high-throughput screening of the main components of traditional Chinese herbs used to treat dementia. Various experimental techniques were used to evaluate the effect of Mat on these two targets both in vitro and in AD mouse model. Mat could inhibit Aβ42-induced cytotoxicity and suppress the Aβ/RAGE signaling pathway in vitro. Additionally, the results of in vivo evaluations of the effects of Mat on the two targets were consistent with the results of our in vitro studies.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Opioid Receptor Products


CAS 122517-78-6 Naltriben mesylate

Naltriben mesylate
(CAS: 122517-78-6)

Naltriben mesylate is a selective and potent δ-opioid receptor antagonist (Ki= 0.013, 19 and 152 nM for δ, μ and κ receptors respectively).

CAS 170098-38-1 Alvimopan dihydrate

Alvimopan dihydrate
(CAS: 170098-38-1)

Alvimopan dihydrate is a novel, orally available peripherally restricted opioid antagonist with low systemic absorption. It accelerates the gastrointestinal rec...

CAS 785835-79-2 JDTic dihydrochloride

JDTic dihydrochloride
(CAS: 785835-79-2)

JDTic dihydrochloride is a highly selective antagonist for the κ-opioid receptor with IC50 value of 0.02nM without affecting the μ- or δ-opioid receptors. It is...

PD-117302
(CAS: 111728-01-9)

PD-117302, a new nonpeptide opioid compound, is a selective kappa-opioid agonist. It has been evaluated in vivo for antinociceptive activity and other effects c...

CAS 83420-94-4 ICI 154,129

ICI 154,129
(CAS: 83420-94-4)

ICI 154,129 is a selective δ opioid antagonist. It is a peptide analog that antagonized the effects of Leu-enkephalin.

CAS 16676-29-2 Naltrexone HCl

Naltrexone HCl
(CAS: 16676-29-2)

Naltrexone significantly suppresses ethanol self-administration and prevents ethanol-induced increases in dialysate dopamine levels.

CAS 156053-89-3 Alvimopan

Alvimopan
(CAS: 156053-89-3)

Alvimopan is a novel, oral, peripherally acting antagonist of the mu opioid receptor, which can help gastrointestinal recovery after surgery. Phase III IC50: Mu...

CAS 380620-88-2 [(pF)Phe4]Nociceptin(1-13)NH2

[(pF)Phe4]Nociceptin(1-13)NH2
(CAS: 380620-88-2)

[(pF)Phe4]Nociceptin(1-13)NH2 is a highly potent and selective nociceptin/orphanin FQ receptor (OP4) agonist peptide (pKi = 10.68; pEC50 = 9.80), with 8000-fold...

Chemical Structure

CAS 519-02-8 (+)-Matrine

Quick Inquiry

Verification code

Featured Items