|Appearance||white solid powder|
|Synonyms||Maropitant; CJ-11972; CJ-11,972; CJ11,972. Cerenia|
Substance P, a neuropeptide, is a sensory neuropeptide and inflammatory mediator. The endogenous receptor for substance P is neurokinin 1 receptor (NK1-receptor...
Eledoisin-Related Peptide is a tachykinin receptor ligand.
L760735 is a high-affinity NK1 receptor antagonist with IC50 value of 0.19 nM. It is selective over NK2 and NK3 receptors. It is used in the synthetic preparati...
GR 159897 is a potent and selective neurokinin NK2 receptor antagonist. GR 159897 competes for binding of [3H]GR100679 to hNK2-transfected CHO cells (pKi = 9.5)...
RC 160 is a cyclic octapeptide somatostatin analog (Ki= 0.7, 5.4, 30.9, 45 and > 1000 nM for sst5, sst2, sst3, sst4 and sst1 receptors respectively). RC 160 is ...
CP 96345 is an effective and selective non-peptide NK1 receptor antagonist and has been found to show activities in restraining neurogenic inflammation in vivo.
Kassinin, a tachykinin peptide derived from the Kassina frog, is secreted as a defense response, and is involved in neuropeptide signalling and shows selectivit...
Rolapitant HCl hydrate
Rolapitant, also known as SCH-619734, is a potent, highly selective, long-acting Neurokinin-1 (NK-1) receptor antagonist with potential antiemetic activity. Unl...
MDL 29913 is a selective NK2 tachykinin receptor antagonist which can be used in the treatment of IBS.
SSR 146977 hydrochloride
SSR 146977 hydrochloride is a potent and selective NK3 receptor antagonist (Ki = 0.26 and 19.3 nM in CHO cells expressing the human NK3 and NK2 receptor, respec...
Netupitant is a selective neurokinin 1 (NK1) receptor antagonist with potential antiemetic activity. Netupitant competitively binds to and blocks the activity o...
Physalaemin, a non-mammalian tachykinin originally isolated from the Physalaemus frog, binds selectively to neurokinin-1 (NK1) receptor with high affinity.
L-733,061, a phenylpiperidine derivative, has been found to be a NK1 receptor antagonist that could probably be antidepressant/ anxiolytic agent and also show a...
SR 140333 is a potent NK1 receptor antagonist (Ki = 0.74 nM. IC50 = 1.6 nM). SR 140333 inhibits substance P-invoked calcium mobilization and outward current (IC...
An agonist of neurokinin 2 (NK2) receptor
SB 223412 is a brain penetrating and orally bioactive non-peptide NK3 receptor antagonist (Ki = 1, 144 and >100000 nM for human NK3, NK2 and NK1 receptors, resp...
CP 99994 dihydrochloride
The hydrochloride salt form of CP 99994, which is a high affinity NK1 antagonist and could attenuate endothelium-dependent contraction induced by substance P.
RP 67580 is a selective non-peptide tachykinin NK1 receptor antagonist with Ki of 2.9 nM, and shows no activity ofr NK2 and NK3 (Ki>10 uM). It exhibits antinoci...
L-732,138 is a highly selective and potent substance P (SP) receptor antagonist. It is also a potent and competitive tachykinin NK1 receptor antagonist with IC5...