Maropitant - CAS 147116-67-4
Catalog number: 147116-67-4
Category: Inhibitor
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Molecular Formula:
C32H40N2O
Molecular Weight:
468.685
COA:
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Targets:
Neurokinin Receptor
Description:
Maropitant is a neurokinin (NK1) receptor antagonist.
Purity:
>98%
Appearance:
white solid powder
Synonyms:
Maropitant; CJ-11972; CJ-11,972; CJ11,972. Cerenia
MSDS:
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InChIKey:
OMPCVMLFFSQFIX-CONSDPRKSA-N
InChI:
InChI=1S/C32H40N2O/c1-32(2,3)27-15-16-28(35-4)26(21-27)22-33-30-25-17-19-34(20-18-25)31(30)29(23-11-7-5-8-12-23)24-13-9-6-10-14-24/h5-16,21,25,29-31,33H,17-20,22H2,1-4H3/t30-,31-/m0/s1
Canonical SMILES:
CC(C)(C)C1=CC(=C(C=C1)OC)CNC2C3CCN(C2C(C4=CC=CC=C4)C5=CC=CC=C5)CC3
1.Evaluation of the antiemetic efficacy of maropitant in dogs medicated with morphine and acepromazine.
Lorenzutti AM1, Martín-Flores M2, Litterio NJ1, Himelfarb MA1, Zarazaga MP1. Vet Anaesth Analg. 2016 Mar;43(2):195-8. doi: 10.1111/vaa.12286. Epub 2015 Jun 19.
OBJECTIVE: To evaluate whether maropitant (1 mg kg(-1) ) injected subcutaneously (SC), administered simultaneously or 30 minutes prior to intramuscular (IM) administration of morphine (0.5 mg kg(-1) ) and acepromazine (0.05 mg kg(-1) ), reduces the incidence of salivation, retching and emesis in dogs.
2.Effects of the neurokinin-1 antagonist maropitant on canine gastric emptying assessed by radioscintigraphy and breath test.
Schmitz S1, Fink T, Failing K, Borsch C, Kunz C, Clemence R, Savary-Bataille K, Neiger R. Tierarztl Prax Ausg K Kleintiere Heimtiere. 2016 Apr 19;44(3). [Epub ahead of print]
OBJECTIVE: Delayed gastric emptying is a well-recognised phenomenon in a number of canine disease conditions. Only a limited number of drugs have been reported to have some gastrokinetic effect in the dog. The aim of this study was to investigate prokinetic effects of maropitant.
3.Comparison of NK-1 Receptor Antagonist (Maropitant) to Morphine as a Pre-Anaesthetic Agent for Canine Ovariohysterectomy.
Marquez M1, Boscan P1, Weir H1, Vogel P1, Twedt DC1. PLoS One. 2015 Oct 29;10(10):e0140734. doi: 10.1371/journal.pone.0140734. eCollection 2015.
OBJECTIVE: To compare the NK-1 receptor antagonist maropitant to morphine during and after surgery in dogs undergoing ovariohysterectomy (OHE).
4.Evaluation of oral maropitant as an antiemetic in cats receiving morphine and dexmedetomidine.
Martin-Flores M1, Sakai DM2, Mastrocco A2, Learn MM2, Campoy L2, Kirch PJ2, Boesch JM2, Gleed RD2. J Feline Med Surg. 2015 Nov 3. pii: 1098612X15613389. [Epub ahead of print]
OBJECTIVES: The aim of the study was to evaluate the antiemetic effects of maropitant, after oral administration, in cats receiving morphine and dexmedetomidine.
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CAS 147116-67-4 Maropitant

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