Marbofloxacin - CAS 115550-35-1
Catalog number: 115550-35-1
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C17H19FN4O4
Molecular Weight:
362.36
COA:
Inquire
Targets:
Antibacterial
Description:
Marbofloxacin exhibits high bactericidal activity against a broad spectrum of aerobic Gram-negative and some Gram-positive bacteria, as well as Mycoplasma spp.
Publictions citing BOC Sciences Products
  • >> More
Purity:
>98%
Synonyms:
N/A
MSDS:
Inquire
1.In vitro Dynamic Pharmacokinetic/Pharmacodynamic (PK/PD) study and COPD of Marbofloxacin against Haemophilus parasuis.
Sun J1, Xiao X2,3, Huang RJ4, Yang T5, Chen Y6, Fang X7, Huang T8, Zhou YF9, Liu YH10,11. BMC Vet Res. 2015 Dec 1;11:293. doi: 10.1186/s12917-015-0604-5.
BACKGROUND: Haemophilus parasuis (H. parasuis) can invade the body and cause systemic infection under stress conditions. Marbofloxacin has been recommended for the treatment of swine infections. However, few studies have investigated the PK/PD characteristics and PK/PD cutoff (COPD) of this drug against H. parasuis.
2.Marbofloxacin-encapsulated microparticles provide sustained drug release for treatment of veterinary diseases.
Lee J1, Kwon HJ2, Ji H2, Cho SH1, Cho EH3, Han HD4, Shin BC5. Mater Sci Eng C Mater Biol Appl. 2016 Mar 1;60:511-7. doi: 10.1016/j.msec.2015.12.004. Epub 2015 Dec 4.
Fluoroquinolone antibiotics with concentration-dependent killing effects and a well-established broad spectrum of activity are used commonly to treat infectious diseases caused by bacteria. However, frequent and excessive administration of these antibiotics is a serious problem, and leads to increased number of drug-resistant bacteria. Thus, there is an urgent need for novel fluoroquinolone antibiotic formulations that minimize the risk of resistance while maximizing their efficacy. In this study, we developed intramuscularly injectable polymeric microparticles (MPs) that encapsulated with marbofloxacin (MAR) and were composed of poly(D,L-lactide-co-glycolic acid) (PLGA) and poloxamer (POL). MAR-encapsulated MP (MAR-MP) had a spherical shape with particle size ranging from 80 μm to 120 μm. Drug loading efficiency varied from 55 to 85% (w/w) at increasing amount of hydrophilic agent, POL. Drug release from MAR-MP demonstrated a significant and sustained increase at increased ratios of POL to PLGA.
3.Pharmacokinetics/pharmacodynamics of marbofloxacin in a Pasteurella multocida serious murine lung infection model.
Qu Y1, Qiu Z2, Cao C3, Lu Y4, Sun M5, Liang C6, Zeng Z7. BMC Vet Res. 2015 Dec 2;11:294. doi: 10.1186/s12917-015-0608-1.
BACKGROUND: Marbofloxacin is a third-generation fluoroquinolone developed solely for veterinary medicine with a broad spectrum of antibacterial activity against some Gram-positive and most Gram-negative bacteria, including the bovine respiratory tract pathogen, Pasteurella multocida. The objective of our study was to elucidate the pharmacokinetics and pharmacodynamics of marbofloxacin in a Pasteurella multocida infected murine lung model, and to estimate the magnitudes of pharmacokinetics-pharmacodynamics parameters associated with various effects.
4.Determination of marbofloxacin in plasma and synovial fluid by ultrafiltration followed by HPLC-MS/MS.
Montesano C1, Curini R1, Sergi M2, Compagnone D3, Celani G4, Varasano V4, Petrizzi L4, Amorena M3. J Pharm Biomed Anal. 2016 May 10;123:31-6. doi: 10.1016/j.jpba.2016.01.061. Epub 2016 Feb 1.
A rapid LC-MS/MS method for the determination of marbofloxacin in plasma and synovial fluid is presented in this study. The method uses a rapid sample preparation which only requires an ultrafiltration step with centrifugal filter devices. The optimized procedure allows a minimal need of sample (175μL), particularly useful for synovial fluid samples which amount is rather limited; it is simple, rapid and easily applicable providing anyhow a satisfactory clean up, demonstrated by post-infusion experiments. On the other hand to maximize the speed of the analysis an ultrafast chromatographic separation has been obtained by selecting a column of 20mm; the reduced run-time is suitable for processing numerous samples on a daily basis. Linearity was assessed in the range 5-2500ngmL(-1); ofloxacin was used as internal standard. LOD and LOQ were respectively 1 and 5ng/mL. The method was successfully applied to a set of samples generated during an experimental veterinary study.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Antibacterial Products


CAS 229016-73-3 Ceftaroline fosamil

Ceftaroline fosamil
(CAS: 229016-73-3)

Ceftaroline fosamil, a cephalosporin antibiotic, is active against methicillin-resistant Staphylococcus aureus (MRSA) and Gram-positive bacteria.

CAS 119478-56-7 Meropenem trihydrate

Meropenem trihydrate
(CAS: 119478-56-7)

Meropenem (trihydrate) is a carbapenem antibiotic, which displaying a broad spectrum of antibacterial activity.

CAS 56-75-7 Chloramphenicol

Chloramphenicol
(CAS: 56-75-7)

Chloramphenicol is an antibiotic useful for the treatment of a number of bacterial infections.

CAS 100986-85-4 Levofloxacin

Levofloxacin
(CAS: 100986-85-4)

Levofloxacin is as efficacious as or more efficacious than that with ciprofloxacin in systemic as well as pyelonephritis infections in mice. Levofloxacin achiev...

CAS 58-71-9 Cephalothin sodium

Cephalothin sodium
(CAS: 58-71-9)

Cephalothin sodium is a semisynthetic first generation cephalosporin having a broad spectrum of antibiotic activity that is administered parenterally used to pr...

CAS 37693-01-9 Clofoctol

Clofoctol
(CAS: 37693-01-9)

Clofoctol is a bacteriostatic antibiotic used to against gram-positive bacteria.

CAS 245342-14-7 LED209

LED209
(CAS: 245342-14-7)

LED209 is a highly selective for histidine sensor kinase QseC that blocks both norepinephrine- and epinephrine-triggered QseC-dependent virulence gene expressio...

CAS 1192500-31-4 Avibactam free acid

Avibactam free acid
(CAS: 1192500-31-4)

Avibactam is a novel investigational non-beta-lactam beta-lactamase inhibitor that is being developed for possible use in combination with ceftaroline in the U....

CAS 118081-34-8 Ceftibuten dihydrate

Ceftibuten dihydrate
(CAS: 118081-34-8)

Dihydrate form of Ceftibuten which is one of the third-generation cephalosporin antibiotics.

CAS 6018-19-5 p-Aminosalicylic acid sodium salt dihydrate

p-Aminosalicylic acid sodium salt dihydr
(CAS: 6018-19-5)

p-Aminosalicylic acid sodium salt dihydrate is one of the antimycobacterial drugs currently used for multidrug-resistant tuberculosis.It is an antibiotic used t...

CAS 2058-46-0 Oxytetracycline hydrochloride

Oxytetracycline hydrochloride
(CAS: 2058-46-0)

Oxytetracycline hydrochloride, a tetracycline derivative isolated from the elaboration products of the actinomycete, Streptomyces rimosus, is an antibacterial c...

CAS 127254-12-0 Sitafloxacin

Sitafloxacin
(CAS: 127254-12-0)

Sitafloxacin, a new-generation, broad-spectrum oral fluoroquinolone that is very active against many Gram-positive, Gram-negative and anaerobic clinical isolate...

CAS 1405-10-3 Neomycin sulfate

Neomycin sulfate
(CAS: 1405-10-3)

Neomycin sulfate belongs to a class of antibiotics known as the aminoglycosides.

CAS 173903-47-4 Tizoxanide

Tizoxanide
(CAS: 173903-47-4)

Tizoxanide is the active metabolite of nitazoxanide, an anti-infective that has been approved for the treatment of diarrhea caused by Giardia lamblia or Crytosp...

CAS 53179-09-2 Sisomicin sulfate

Sisomicin sulfate
(CAS: 53179-09-2)

Sisomicin sulfate is an aminoglycoside antibiotic displaying a broad spectrum antibiotic activity.

CAS 121123-17-9 Cefprozil monohydrate

Cefprozil monohydrate
(CAS: 121123-17-9)

Cefprozil hydrate (Cefzil) is a second-generation cephalosporin type antibiotic. Cefprozil hydrate (Cefzil) can be used to treat bronchitis, ear infections, ski...

CAS 364622-82-2 Doripenem Hydrate

Doripenem Hydrate
(CAS: 364622-82-2)

Doripenem Hydrate is an ultra-broad-spectrum injectable antibiotic, used to treat complicated intra-abdominal infections and complicated urinary tract infection...

CAS 773-76-2 Chloroxine

Chloroxine
(CAS: 773-76-2)

Chloroxine has bacteriostatic, fungistatic and antiprotozoal properties. It is effective against Streptococci, Staphylococci, Candida, Candida albicans, Shigell...

CAS 79-57-2 Oxytetracycline

Oxytetracycline
(CAS: 79-57-2)

Oxytetracycline (Terramycin) was the second of the broad-spectrum tetracycline group of antibiotics to be discovered.

CAS 32887-01-7 Mecillinam

Mecillinam
(CAS: 32887-01-7)

Mecillinam is an extended-spectrum penicillin antibiotic as an active antibacterial against gram-negative bacteria.

Chemical Structure

CAS 115550-35-1 Marbofloxacin

Quick Inquiry

Verification code

Featured Items