|Synonyms||4,4-Difluoro-N-[(1S)-3-[(3-exo)-3-[3-methyl-5-(1-methylethyl-d6)-4H-1,2,4-triazol-4-yl]-8-azabicyclo[3.2.1]oct-8-yl]-1-phenylpropyl]cyclohexanecarboxamide; UK 427857-d6;|
|Description||Selective CCR5 antagonist|
|Targets||CCR | HIV|
Approximately 2.4–2.9 μM of BI-D was required to inhibit 50% of HIV-Luc infection of WT and Hdgfrp2 KO cells, while the IC50 decreased dramatically, to 160–200 ...
Potent and selective CCR2 antagonist with low nM affinity for CCR2 on human monocytes
BMS-626529 is a member of the new drug class of HIV-1 attachment inhibitors currently in development. BMS-663068 is the phosphonooxymethyl prodrug of BMS-626529...
A novel, potent and selective small molecule antagonist of the mouse CCR2 receptor
BMS-663749 is HIV-1 attachment inhibitor.
Nelfinavir is a HIV protease inhibitor; antiretroviral; and anti-tumor agent.
Dolutegravir (GSK1349572) is a two-metal-binding HIV integrase inhibitor with IC50 of 2.7 nM, modest activity against raltegravir-resistant signature mutants Y1...
Emtricitabine moderately reduces hepatocyte proliferation independent of effects on mtDNA in HepG2 human hepatoma cells.
Selective, non-peptide CCR8 agonist
K-11777 is a potent, irreversible cysteine protease inhibitor. Besides， K11777 is not only a substrate but also a mechanism-based inhibitor of CYP3A4.
Potent and selective CCR3 antagonist
AZD5672 is CCR5 receptor antagonist originated by AstraZeneca. In Jul 2009, Phase-II for Rheumatoid arthritis in USA was discontinued.
CP-481715 is a potent and selective CCR1 antagonist with >100-fold selective for CCR1 as compared with a panel of G-protein-coupled receptors including related ...
Atazanavir is a HIV protease inhibitor with Ki of 2.66 nM. It is an antiretroviral drug of the protease inhibitor (PI) class. Like other antiretrovirals, it is ...
BMS-488043 is a small-molecule HIV fusion inhibitor.
Potent CCR1 antagonist
BI 224436 is a novel HIV-1 non-catalytic-site integrase inhibitor; has antiviral EC50s of <15 nM against different HIV-1 laboratory strains and cellular cytotox...
HIV-1 integrase inhibitor
HIV-1 integrase inhibitor is uesful for anti-HIV, which can target HIV-1 integrase and depress the activity in the treatment of HIV infection, AIDS, and other s...
A CCR1 agonist; A bisquinoline compound
Potent, selective and orally bioavailable CCR2 antagonist with IC50 of 3.7 nM