Manninotriose - CAS 13382-86-0
Catalog number: 13382-86-0
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C18H32O16
Molecular Weight:
504.44
COA:
Inquire
Targets:
Others
Description:
Manninotriose, a carbohydrate compound, has been found to be involved in RFO metabolism of red dead deadnettle and probably have antioxidant activity.
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Purity:
>98%
Appearance:
Powder
Synonyms:
Gal(a,1-6)Gal(a,1-6)Glu
Solubility:
10 mM in DMSO
Storage:
-20ºC Freeze
MSDS:
Inquire
Application:
Manninotriose has been found to be involved in RFO metabolism of red dead deadnettle and probably have antioxidant activity.
Quality Standard:
Enterprise Standard
Shelf Life:
As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly
Quantity:
Milligrams-Grams
InChIKey:
FZWBNHMXJMCXLU-YRBKNLIBSA-N
InChI:
InChI=1S/C18H32O16/c19-1-5(21)9(23)10(24)6(22)3-31-17-16(30)14(28)12(26)8(34-17)4-32-18-15(29)13(27)11(25)7(2-20)33-18/h1,5-18,20-30H,2-4H2/t5-,6+,7+,8+,9+,10+,11-,12-,13-,14-,15+,16+,17-,18-/m0/s1
Canonical SMILES:
C(C1C(C(C(C(O1)OCC2C(C(C(C(O2)OCC(C(C(C(C=O)O)O)O)O)O)O)O)O)O)O)O
1.[Optimization of manninotriose preparation from stachoyse].
Wu WH1, Wen XS, Zhao Y. Zhong Yao Cai. 2007 Jul;30(7):848-51.
OBJECTIVE: To optimize the processing of mannatriose preparation from stachyose by acidolysis.
2.[Purification technology of manninotirose in Rehmanniae Radix Praeparata by D-101 microporous adsorption resin].
Wang XX, Qian J, Wu Y, Yan BP, Wang ZZ, Xiao W. Zhongguo Zhong Yao Za Zhi. 2015 Jun;40(12):2340-4.
This paper was aim to optimize the purification technology of Rehmanniae Radix Praeparata extract with macroporous adsorption resin. With the content of manninotriose as index, the absorptive flow and time were investigated, as well as kinds, amount, flow of eluent. D-101 type macroporous adsorption resin was the best choice for the purification of manninotriose. The optimized parameters were as follows: the content of manninotriose at 161.16-53.72 mg x g(-1), absorption time 240 min, eluting solvent of purified water, volume flow at 1.5 BV x h(-1), and eluant volume at 6 BV. D-101 type macroporous adsorption resin could significantly increase the purity of Rehmanniae Radix Praeparata extract with the advantage of high absorption, remove most part of impurity, and the effect of semi-works production was better.
3.Treatment of acute lymphoblastic leukemia from traditional chinese medicine.
Hsiao YL1, Chang PC1, Huang HJ2, Kuo CC1, Chen CY3. Evid Based Complement Alternat Med. 2014;2014:601064. doi: 10.1155/2014/601064. Epub 2014 May 22.
Acute lymphoblastic leukemia (ALL) is a cancer that immature white blood cells continuously overproduce in the bone marrow. These cells crowd out normal cells in the bone marrow bringing damage and death. Methotrexate (MTX) is a drug used in the treatment of various cancer and autoimmune diseases. In particular, for the treatment of childhood acute lymphoblastic leukemia, it had significant effect. MTX competitively inhibits dihydrofolate reductase (DHFR), an enzyme that participates in the tetrahydrofolate synthesis so as to inhibit purine synthesis. In addition, its downstream metabolite methotrexate polyglutamates (MTX-PGs) inhibit the thymidylate synthase (TS). Therefore, MTX can inhibit the synthesis of DNA. However, MTX has cytotoxicity and neurotoxin may cause multiple organ injury and is potentially lethal. Thus, the lower toxicity drugs are necessary to be developed. Recently, diseases treatments with Traditional Chinese Medicine (TCM) as complements are getting more and more attention.
4.Changes in the carbohydrate composition of legumes after soaking and cooking.
Vidal-Valverde C1, Frías J, Valverde S. J Am Diet Assoc. 1993 May;93(5):547-50.
Using a high-performance liquid chromatography (HPLC) method, researchers analyzed the sugar composition of chick-peas, kidney beans, and lentils at various points in the preparation and cooking process: after soaking, after "normal" cooking (ie, boiling), after pressure-cooking, and after cooked legumes had been held at 35 degrees C for 5 hours. There was a considerable decrease in the amount of monosaccharides, disaccharides, and raffinose oligosaccharides in chick-peas and kidney beans after soaking and cooking. This change in carbohydrate composition was less pronounced when the cooking water was not drained before analysis, which was the method used when analyzing the lentils. Method of cooking (either boiling or pressure-cooking) did not have different effects on the sugar composition of chick-peas and lentils, but loss of oligosaccharides was slightly higher when kidney beans were boiled than when they were pressure-cooked. Loss of alpha-galactosides occurred in chick-peas and kidney beans that had been boiled and then held at 35 degrees C for 5 hours.
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CAS 13382-86-0 Manninotriose

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