Mafenide hydrochloride - CAS 138-37-4
Catalog number:
138-37-4
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C8H12N2O2S
Molecular Weight:
222.69
COA:
Inquire
Targets:
Antibacterial
Description:
The hydrochloride salt form of Mafenide, a Sulfanilamide derivative, could be used as an antibiotic. Mafenide could oftn be existed as acetate salt form.
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Purity:
98%
Appearance:
Powder
Synonyms:
Mafenide hydrochloride; 4-Aminomethylbenzenesulfonamide hydrochloride; Marfanil; 4-(Aminomethyl)benzenesulfonamide hydrochloride
Solubility:
10 mM in H2O
Storage:
-20ºC Freeze
MSDS:
Inquire
Application:
The hydrochloride salt form of Mafenide could be used as an antibiotic. Mafenide could oftn be existed as acetate salt form.
Shelf Life:
As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly
Quantity:
Grams-Kilos
InChIKey:
SIACJRVYIPXFKS-UHFFFAOYSA-N
InChI:
InChI=1S/C7H10N2O2S.ClH/c8-5-6-1-3-7(4-2-6)12(9,10)11;/h1-4H,5,8H2,(H2,9,10,11);1H
Canonical SMILES:
C1=CC(=CC=C1CN)S(=O)(=O)N.Cl
1.Wet disc testing of mafenide hydrochloride, chlorhexidine gluconate, and triple antibiotic solution against bacteria isolated from burn wounds.
Holder IA1. J Burn Care Rehabil. 1990 Jul-Aug;11(4):301-4.
Various antimicrobial solutions for topical use on burn wounds tested, in vitro with a newly described wet disc assay, for their activity against bacterial isolates from patients with burns. The antimicrobial activity of triple antibiotic solution was shown to reside in the neomycin component. The activity of 2.5% mafenide hydrochloride solution was equal to that of 4% mafenide HCl and could be used clinically with significant savings and perhaps, fewer side effects. Chlorhexidine gluconate had broad antimicrobial activity in an 0.05% solution in water; however, dissolving the active ingredient in saline nullified its activity significantly. The wet disc assay appears to be a useful means by which to assess the efficacy of solutions for topical use.
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CAS 138-37-4 Mafenide hydrochloride

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