Mafenide - CAS 138-39-6
Catalog number: 138-39-6
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C7H10N2O2S
Molecular Weight:
186.23
COA:
Inquire
Targets:
Antibacterial
Description:
Mafenide is a sulfonamide-type medication.
Purity:
>98%
Synonyms:
Sulfamylon
MSDS:
Inquire
InChIKey:
TYMRLRRVMHJFTF-UHFFFAOYSA-N
InChI:
InChI=1S/C7H10N2O2S/c8-5-6-1-3-7(4-2-6)12(9,10)11/h1-4H,5,8H2,(H2,9,10,11)
Canonical SMILES:
C1=CC(=CC=C1CN)S(=O)(=O)N
1.Effect of Olea ointment and Acetate Mafenide on burn wounds - A randomized clinical trial.
Zahmatkesh M1, Manesh MJ2, Babashahabi R3. Iran J Nurs Midwifery Res. 2015 Sep-Oct;20(5):599-603. doi: 10.4103/1735-9066.164507.
BACKGROUND: The main goals in treating burns are to accelerate tissue renovation and prevent infection. Topical antibiotics are used in the treatment of burns, but they can cause side effects. Recently, a traditional ointment (Olea) has been used in Iran in the treatment of burns. This study examines the effect of topical honey ointment in healing of burn patients.
2.Evaluation of the Antimicrobial Effect of Chitosan/Polyvinyl Alcohol Electrospun Nanofibers Containing Mafenide Acetate.
Abbaspour M1, Sharif Makhmalzadeh B1, Rezaee B1, Shoja S2, Ahangari Z3. Jundishapur J Microbiol. 2015 Oct 28;8(10):e24239. doi: 10.5812/jjm.24239. eCollection 2015.
BACKGROUND: Chitosan, an important biodegradable and biocompatible polymer, has demonstrated wound-healing and antimicrobial properties.
3.In vitro toxicity and activity of Dakin's solution, mafenide acetate, and amphotericin B on filamentous fungi and human cells.
Barsoumian A1, Sanchez CJ, Mende K, Tully CC, Beckius ML, Akers KS, Wenke JC, Murray CK. J Orthop Trauma. 2013 Aug;27(8):428-36. doi: 10.1097/BOT.0b013e3182830bf9.
OBJECTIVES: Posttraumatic invasive fungal infections threaten critically injured combat-related injuries and require a combination of extensive surgery and systemic antifungal therapy, along with topical antimicrobials used adjunctively to control the infection. We evaluated the in vitro activity of topical agents in varying combinations and concentrations against molds from patients that were responsible for wound invasive fungal infections and the topical agents' toxicity to human cells.
4.A simple cost-saving measure: 2.5% mafenide acetate solution.
Ibrahim A1, Fagan S, Keaney T, Sarhane KA, Hursey DA, Chang P, Sheridan R, Ryan C, Tompkins R, Goverman J. J Burn Care Res. 2014 Jul-Aug;35(4):349-53. doi: 10.1097/BCR.0b013e3182a22715.
The optimal concentration of mafenide acetate solution for use in the treatment of burns is unknown. Despite data supporting the use of a 2.5% solution, 5% formulation is traditionally used, and has been the highest-costing medication on formulary. The aim of the current study is to evaluate cost and patient outcomes associated with a new policy implementing the use of 2.5% solution in burn patients and restricting the 5% formulation to specific indications only. A retrospective review of all patients receiving mafenide acetate solution at a single pediatric burn hospital was performed before and after the initiation of the new policy on the use of 5 vs 2.5% solution. Duration of therapy, adverse events, cost, incidence of wound infection, and bacteremia were analyzed. In 2009, 69 patients were treated with 5% mafenide acetate solution for a total cost of $125,000 ($1811 per patient). In 2010, after the initiation of the policy, 48 patients were treated: 19 received 5% mafenide acetate solution with appropriate indication, whereas the remaining 29 received 2.
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CAS 138-39-6 Mafenide

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