Macelignan - CAS 107534-93-0
Catalog number: 107534-93-0
Category: Inhibitor
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Macelignan is a natural compound isolated from Myristica fragrans Houtt. It possesses therapeutic potentials against neurodegenerative diseases with oxidative stress and neuroinflammation.
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1.[Studies on chemical constituents of Kadsura Longepedunculata].
You ZP;Liao MJ;Shi YH;Chen YZ Yao Xue Xue Bao. 1997 Jun;32(6):455-7.
The chemical constituents of Kadsura Longepedunculata collected from Zhejiang province were studied. Six compounds were isolated and their structures were elucidated based on physical and spectral analysis. Among them, one is a new compound, which is named kadsulactone acid (I) and the others are kadsulactone (II), (+)-anwulignan (III), mesodihydroguaiaretic acid (IV), d-epidalbacin(V) and beta-sitosterol (VI).
2.Cytotoxic and anti-tumor activities of lignans from the seeds of Vietnamese nutmeg Myristica fragrans.
Thuong PT;Hung TM;Khoi NM;Nhung HT;Chinh NT;Quy NT;Jang TS;Na M Arch Pharm Res. 2014 Mar;37(3):399-403. doi: 10.1007/s12272-013-0185-4. Epub 2013 Jul 23.
Four lignans, meso-dihydroguaiaretic acid (DHGA), macelignan, fragransin A2 and nectandrin B, were isolated from the seeds of Myristica fragrans (Vietnamese nutmeg) and investigated for their cytotoxic activity against eight cancer cell lines. Of these, DHGA exhibited potent cytotoxicity against H358 with IC50 value of 10.1 μM. In addition, DHGA showed antitumor activity in allogeneic tumor-bearing mice model.
3.Separation of Leucas aspera, a medicinal plant of Bangladesh, guided by prostaglandin inhibitory and antioxidant activities.
Sadhu SK;Okuyama E;Fujimoto H;Ishibashi M Chem Pharm Bull (Tokyo). 2003 May;51(5):595-8.
According to the traditional usage of the plant for antiinflammation and analgesia, Leucas aspera was tested for its prostaglandin (PG) inhibitory and antioxidant activities. The extract showed both activities, i.e., inhibition at 3 x 10(-4) g/ml against PGE(1)- and PGE(2)-induced contractions in guinea pig ileum and a 1, 1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging effect. The separation guided by the activities in these dual assay methods provided eight lignans and four flavonoids, LA-1- -12, among which LA-1- -7 and LA-10- -12 were identified as nectandrin B, meso-dihydroguaiaretic acid, macelignan, acacetin, apigenin 7-O-[6"-O-(p-coumaroyl)-beta-D-glucoside], chrysoeriol, apigenin, erythro-2-(4-allyl-2, 6-dimethoxyphenoxy)-1-(4-hydroxy-3-methoxyphenyl)propan-1-ol, myristargenol B, and machilin C, respectively. LA-8 was determined to be (-)-chicanine, the new antipode of the (+) compound, by spectroscopic methods including CD and ORD. Chiral-HPLC analysis of LA-9 showed that it was a mixture of two enantiomers, (7R, 8R)- and (7S, 8S)-licarin A. All of these components were first isolated from L. aspera. PG inhibition was observed in LA-1, LA-2, and LA-5, and antioxidant activity in LA-1- -3 and LA-8- -12.
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CAS 107534-93-0 Macelignan

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