Macbecin I - CAS 73341-72-7
Catalog number: 73341-72-7
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
Molecular Weight:
Macbecin I is an ansamycin antibiotic compound that inhibits Hsp90 by binding to the ATP-binding site.IC50 = 2μM. Exhibits antitumor and cytocidal activities (IC50~ 0.4 μM) by causing degradation of key oncogenic client proteins such as ErbB2 and cRaf1. Exhibits higher affinity and potency than geldanamycin.
Brife Description:
Macbecin I is a Hsp90 inhibitor.
Yellow lyophilised solid
Soluble in DMSO
Desiccate at -20°C
Quality Standard:
Canonical SMILES:
1.Studies on the syntheses of benzoquinone ansamycin antibiotics. Syntheses of the C5-C15 subunits of macbecin I, geldanamycin, and herbimycin A.
Belardi JK1, Micalizio GC. Org Lett. 2006 May 25;8(11):2409-12.
[reaction: see text] A general and convergent route to the C(5)-C(15) subunits of the benzoquinone ansamycin antibiotics macbecin I, geldanamycin, and herbimycin A is described. Each subunit is prepared by the stepwise coupling of differentially functionalized aldehydes with a pentenyl dianion equivalent derived from diastereoselective pentynylation and regioselective reductive coupling.
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CAS 73341-72-7 Macbecin I

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