|Description||LY-404,039, also known as pomaglumetad, is an amino acid analog drug that acts as a highly selective agonist for the metabotropic glutamate receptor group II subtypes mGluR2 and mGluR3.|
LY 379268 is a group II mGlu receptor agonist with EC50 values of 2.69 and 4.48 nM for hmGlu2 and hmGlu3. Some research shows that LY379268 can attenuate cocain...
(±)-LY 395756 is a mixed mGlu2 agonist/mGlu3 antagonist.
VU0357121 is a novel positive allosteric modulator (PAM) of mGlu5 with EC50 of 33 nM, is inactive or very weakly antagonizing at other mGlu receptor subtypes.
LY 456236 hydrochloride
LY 456236 hydrochloride is a mGlu1 receptor antagonist with IC50 value of 143 nM. It may be used in the treatment of chronic pain.
LY 2389575 hydrochloride
LY 2389575 hydrochloride is a mGluR3 receptor antagonist with IC50 value of 190 nM.
FTIDC is an orally bioactive mGlu1 receptor negative allosteric modulator (IC50 = 5.8 and 6200 nM for mGlu1 and mGlu5, respectively) and an mGlu1 receptor inver...
SIB 1893 is a selective and noncompetitive antagonist for the metabotropic glutamate mGlu5 receptor subtype (IC50 = 0.3 μM and > 100 μM at hmGlu5, hmGlu1b, hmGl...
EGLU is a group II mGluR antagonist and also a selective antagonist of presynaptically-mediated (1S,3S)-ACPD-induced depression of motoneuron excitation in neon...
ACET, a potent and selective GluR5-containing kainate receptor antagonist, has been found to exhibit activities in blocking induction of NMDA receptor-independe...
(RS)-3-Hydroxyphenylglycine is an agonist at PI-linked metabotropic glutamate receptors.
SIB 1757 is a highly selective antagonist for the metabotropic glutamate mGlu5 receptor subtype (IC50 = 0.4 μM and > 30 μM at hmGlu5, hmGlu1b, hmGlu2, hmGlu4, h...
NPS 2390 is a Group I mGlu antagonist. NPS 2390 acts as a noncompetitive antagonist of mGluR1 and mGluR5 with IC50 values of 5.2 and 82 nM.
VU 0155041 is a potent positive allosteric modulator at mGlu4 receptors (EC50 = 798 and 693 nM at human and rat mGlu4 receptors, respectively). VU 0155041 displ...
MFZ 10-7 is a mGlu5 receptor negative allosteric modulator. It can inhibit mGlu5 glutamate-mediated calcium mobilization with IC50 value of 1.22 nM. MFZ 10-7 ca...
L-Glutamine is one of the 20 amino acids encoded by the standard genetic code.
(1R,2S)-VU0155041 is a partial mGluR4-positive allosteric modulator (EC50= 2.35 μM) that dependently attenuated hyperalgesia in neuropathic pain model rats.
Lu AF21934 is a selective and brain-penetrating positive allosteric modulator (PAM) of mGlu4 receptors (IC50= 500 nM) on the harmaline-induced tremor and other ...
YM 230888 is a selective mGlu1 antagonist (Ki = 13 nM) that inhibits mGlu1-mediated inositol phosphate production in rat cerebellar granule cells (IC50 = 13 nM)...
TASP 0433864 is a selective and positive allosteric modulator of mGlu2 receptor (EC50 = 199 and 206 nM for human and rat receptors, respectively) with no agonis...
(S)-3-Carboxy-4-hydroxyphenylglycine has been found to be a mixed group II mGlu agonist as well as group I metabotropic glutamate receptor antagonist.