LY341495 - CAS 201943-63-7
Catalog number:
201943-63-7
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C20H19NO5
Molecular Weight:
353.37
COA:
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Targets:
mGluR
Description:
Very selective nanomolar potent antagonist for group II mGlu receptors. Also a relatively potent antagonist for group III mGlu receptors at high nanomolar to low micromolar concentrations. Kd values for human receptors are 1.67 (mGlu2), 0.75 (mGlu3), 31.6 (mGlu6), 72.7 (mGlu7a) and 14 nM (mGlu8a). IC50 values are 7.8, 8.2 and 22 μM for mGlu1a, mGlu5a and mGlu4 receptors, respectively. Readily brain penetrant and active in vivo.
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Purity:
>98%
Synonyms:
LY 341495; LY-341495
MSDS:
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1.Lower [3H]LY341495 binding to mGlu2/3 receptors in the anterior cingulate of subjects with major depressive disorder but not bipolar disorder or schizophrenia.
McOmish CE1, Pavey G2, Gibbons A2, Hopper S2, Udawela M2, Scarr E3, Dean B4. J Affect Disord. 2016 Jan 15;190:241-8. doi: 10.1016/j.jad.2015.10.004. Epub 2015 Oct 23.
INTRODUCTION: The glutamatergic system has recently been implicated in the pathogenesis and treatment of major depressive disorders(MDD) and mGlu2/3 receptors play an important role in regulating glutamatergic tone. We therefore measured cortical levels of mGlu2/3 to determine if they were changed in MDD.
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CAS 201943-63-7 LY341495

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