|Description||LY310762 has a higher affinity for the guinea pig 5-HT1D receptor than for the 5-HT1B receptor. LY310762 potentiates the potassium-induced [3H]5-HT outflow from guinea pig cortical slices with an EC50 of 30 nM.|
The hydrochloride salt form of Agomelatine that is an antidepressant agent for acting as an antagonism of the 5-HT2C receptor. It is also an antagonist of 5-HT2...
Tianeptine is a selective facilitator of 5-HT uptake in vitro and in vivo with psychostimulant, anti-ulcer and anti-emetic properties.
8-OH-DPAT (8-Hydroxy-DPAT) is an agonist that has selectivity for 5-HT1A receptor (pIC50 = 8.19). It was subsequently found to be a serotonin reuptake inhibitor...
A potent dual antagonist of α1-adrenergic receptor and 5-HT2 receptor
Azasetron HCl is a selective 5-HT3 receptor antagonist with IC50 of 0.33 nM used in the management of nausea and vomiting induced by cancer chemotherapy.
The hydrochloride salt form of Alosetron, a 5HT3-receptor antagonist, could be used against bowel syndrome.
SB-269970 is a selective 5-HT7 receptor antagonist (pKi of 8.3) with >50-fold selectivity against other receptors, on amphetamine and ketamine-induced hyperacti...
Eletriptan is Serotonin 1D receptor agonist originated by Pfizer. It is a second generation triptan drug. It is used as an abortive medication, blocking a migra...
Zolmitriptan is a selective serotonin receptor agonist.
The citrate salt form of tandospirone, a partial 5HT1A receptors agonist, could be effective as an antianxiety and antidepressant agent.
LY 278584 is a 5-HT3-receptor antagonist and no detailed information has been published yet.
Nelotanser is Serotonin 2A receptor inverse agonist. In Aug 2016, Axovant Sciences initiated a phase-II clinical trial in Lewy body disease in USA.
LY-293284 is a Serotonin 1A receptor agonist developed by Eli Lilly. It is a selective 5-HT1A receptor full agonist. LY-293284 is far more selective for 5-HT1A ...
Almotriptan Malate is a selective 5-hydroxytryptamine1B/1D (5-HT1B/1D) receptor agonist, used for the treatment of Migraine attacks in adults.
Thioproperazine is a potent neuroleptic with antipsychotic properties, for the treatment of all types of acute and chronic schizophrenia, including those which ...
Ondansetron is a serotonin 5-HT3 receptor antagonist used mainly as an antiemetic.
LY 344864 is a brain penetrant, full agonist that specifically targets 5-HT1F receptor (pKi = 8.2) with > 80-fold selectivity over other serotonin receptors (Ki...
Zatosetron has been identified as a potent, orally available, long-acting, selective 5HT3 receptor antagonist, which is potentially useful in the treatment of c...
The hydrochloride salt form of Ramosetron, a benzimidazol derivative, could be used to against nausea and vomiting for acting as a 5-HT3 receptor antagonist.
Eltoprazine belongs the phenylpiperazine class which is a serenic or antiaggressive agent. It acts as an agonist at the 5-HT1A and 5-HT1B receptors and as an an...