LY2801653 dihydrochloride - CAS 1206801-37-7
Catalog number: 1206801-37-7
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C30H24Cl2F2N6O3
Molecular Weight:
625.45
COA:
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Targets:
c-Met/HGFR
Description:
LY2801653 is a type-II ATP competitive, slow-off inhibitor of MET tyrosine kinase with a dissociation constant (K(i)) of 2 nM, a pharmacodynamic residence time (K(off)) of 0.00132 min(-1) and t(1/2) of 525 min [1]. LY2801653 was found to have potent activity against several other receptor tyrosine oncokinases including MST1R, FLT3, AXL, MERTK, TEK, ROS1, DDR1/2 and against the serine/threonine kinases MKNK1/2. LY2801653 demonstrated in vitro effects on MET pathway-dependent cell scattering and cell proliferation; in vivo anti-tumor effects in MET amplified (MKN45), MET autocrine (U-87MG, and KP4) and MET over-expressed (H441) xenograft models; and in vivo vessel normalization effects.
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Purity:
>98%
Synonyms:
LY-2801653 dihydrochloride; LY 2801653 dihydrochloride
MSDS:
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CAS 1206801-37-7 LY2801653 dihydrochloride

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