LY2801653 dihydrochloride - CAS 1206801-37-7
Catalog number: 1206801-37-7
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C30H24Cl2F2N6O3
Molecular Weight:
625.45
COA:
Inquire
Targets:
c-Met/HGFR
Description:
LY2801653 is a type-II ATP competitive, slow-off inhibitor of MET tyrosine kinase with a dissociation constant (K(i)) of 2 nM, a pharmacodynamic residence time (K(off)) of 0.00132 min(-1) and t(1/2) of 525 min [1]. LY2801653 was found to have potent activity against several other receptor tyrosine oncokinases including MST1R, FLT3, AXL, MERTK, TEK, ROS1, DDR1/2 and against the serine/threonine kinases MKNK1/2. LY2801653 demonstrated in vitro effects on MET pathway-dependent cell scattering and cell proliferation; in vivo anti-tumor effects in MET amplified (MKN45), MET autocrine (U-87MG, and KP4) and MET over-expressed (H441) xenograft models; and in vivo vessel normalization effects.
Publictions citing BOC Sciences Products
  • >> More
Purity:
>98%
Synonyms:
LY-2801653 dihydrochloride; LY 2801653 dihydrochloride
MSDS:
Inquire
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related c-Met/HGFR Products


CAS 877399-52-5 Crizotinib

Crizotinib
(CAS: 877399-52-5)

Crizotinib is an anti-cancer drug acting as an ALK (anaplastic lymphoma kinase) and ROS1 (c-ros oncogene 1) inhibitor.

Glesatinib hydrochloride
(CAS: 1123838-51-6)

The hydrochloride salt form of Glesatinib, an inhibitor of tyrosine kinase, could be effectively targeting tumors that are driving to grow through MET and AXL r...

CAS 1357072-61-7 c-Met inhibitor 1

c-Met inhibitor 1
(CAS: 1357072-61-7)

c-Met inhibitor 1 is an inhibitor of the c-Met receptor signaling pathway useful for the treatment of cancer including gastric, glioblastoma, and pancreatic can...

CAS 477575-56-7 PHA665752

PHA665752
(CAS: 477575-56-7)

PHA665752 is a small-molecule inhibitor of c-Met/HGF/SF signaling c-Met is highly expressed in most tumors from patients with advanced-stage, metastatic NBL....

CAS 1283000-43-0 MK-8033 hydrochloride

MK-8033 hydrochloride
(CAS: 1283000-43-0)

MK-8033 binds 3-fold more tightly to phosphorylated c-Met kinase domain (Kd= 3.2 nM) than to its unphosphorylated counterpart (Kd = 10.4 nM). Signigicantly, MK-...

CAS 875337-44-3 MGCD-265

MGCD-265
(CAS: 875337-44-3)

MGCD-265 is a potent, multi-target and ATP-competitive inhibitor of c-Met and VEGFR1/2/3 with IC50 of 1 nM, 3 nM/3 nM/4 nM, respectively and also inhibits Ron a...

CAS 1100598-32-0 Tepotinib

Tepotinib
(CAS: 1100598-32-0)

Tepotinib, also known as EMD 1214063 and MSC2156119, is an inhibitor of MET tyrosine kinase with potential antineoplastic activity. MET tyrosine kinase inhibito...

LCRF-0004
(CAS: 1229611-73-7)

This active molecular is a selective RON receptor tyrosine kinase inhibitor. The RON receptor tyrosine kinase has been reported that it usually overexpressed in...

CAS 956905-27-4 PF-04217903

PF-04217903
(CAS: 956905-27-4)

PF-04136309 is an orally available human chemokine receptor 2 (CCR2) antagonist with potential immunomodulating and antineoplastic activities. Upon oral adminis...

CAS 1391426-24-6 Lys01 trihydrochloride

Lys01 trihydrochloride
(CAS: 1391426-24-6)

Lys01 trihydrochloride, a water-soluble salt of Lys01, is a selective and orally available inhibitor of AXL and c-Met with IC50 values of 7 nM and 12 nM, respec...

SCR-1481B1
(CAS: 1174161-86-4)

SCR-1481B1, also known as c-Met inhibitor 2, is an effective inhibitor of MET kinase so that probably has anti-tumor activity. It is also found to be an inhibit...

CAS 1002304-34-8 AMG208

AMG208
(CAS: 1002304-34-8)

AMG 208 is a selective small-molecule inhibitor of the proto-oncogene c-Met with potential antineoplastic activity. C-Met encodes the hepatocyte growth factor r...

CAS 905854-02-6 Tivantinib

Tivantinib
(CAS: 905854-02-6)

Tivantinib (ARQ-197) is an orally bioavailable small molecule inhibitor of c-Met with potential antineoplastic activity. c-Met inhibitor ARQ 197 binds to the c-...

CAS 917879-39-1 MK-2461

MK-2461
(CAS: 917879-39-1)

MK-2461 is a novel ATP-competitive multitargeted inhibitor of activated c-Met. MK-2461 inhibited in vitro phosphorylation of a peptide substrate recognized by w...

CAS 943540-75-8 JNJ-38877605

JNJ-38877605
(CAS: 943540-75-8)

JNJ-38877605 is an ATP-competitive inhibitor of c-Met with IC50 of 4 nM, 600-fold selective for c-Met than 200 other tyrosine and serine-threonine kinases.

CAS 1206799-15-6 LY2801653

LY2801653
(CAS: 1206799-15-6)

LY2801653 is an orally available, small molecule inhibitor of the proto-oncogene c-Met with potential antineoplastic activity.

CAS 956906-93-7 PF-04217903 methanesulfonate

PF-04217903 methanesulfonate
(CAS: 956906-93-7)

PF-04217903 methanesulfonate is a selective ATP-competitive c-Met inhibitor and is susceptible to oncogenic mutations (no activity to Y1230C mutant). It showed ...

CAS 1025720-94-8 BMS-777607

BMS-777607
(CAS: 1025720-94-8)

BMS-777607 is a novel prodrug of the dual Met/VEGFR-2 inhibitor.

CAS 1001917-37-8 MK-8033

MK-8033
(CAS: 1001917-37-8)

MK8033 is a novel and specific dual ATP competitive c-Met/Ron inhibitor (IC50=1 nM Wt c-Met) under investigation as a treatment for cancer.

CAS 1022150-57-7 SGX-523

SGX-523
(CAS: 1022150-57-7)

SGX523 is a novel, ATP-competitive kinase inhibitor remarkable for its exquisite selectivity for MET. SGX523 potently inhibited MET with an IC50 of 4 nmol/L an...

Chemical Structure

CAS 1206801-37-7 LY2801653 dihydrochloride

Quick Inquiry

Verification code

Featured Items