LY2801653 dihydrochloride - CAS 1206801-37-7
Catalog number:
1206801-37-7
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C30H24Cl2F2N6O3
Molecular Weight:
625.45
COA:
Inquire
Targets:
c-Met/HGFR
Description:
LY2801653 is a type-II ATP competitive, slow-off inhibitor of MET tyrosine kinase with a dissociation constant (K(i)) of 2 nM, a pharmacodynamic residence time (K(off)) of 0.00132 min(-1) and t(1/2) of 525 min [1]. LY2801653 was found to have potent activity against several other receptor tyrosine oncokinases including MST1R, FLT3, AXL, MERTK, TEK, ROS1, DDR1/2 and against the serine/threonine kinases MKNK1/2. LY2801653 demonstrated in vitro effects on MET pathway-dependent cell scattering and cell proliferation; in vivo anti-tumor effects in MET amplified (MKN45), MET autocrine (U-87MG, and KP4) and MET over-expressed (H441) xenograft models; and in vivo vessel normalization effects.
Publictions citing BOC Sciences Products
  • >> More
Purity:
>98%
Synonyms:
LY-2801653 dihydrochloride; LY 2801653 dihydrochloride
MSDS:
Inquire
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related c-Met/HGFR Products


AMG-337
(CAS: 1173699-31-4)

AMG 337 is an orally bioavailable inhibitor of the proto-oncogene c-Met with potential antineoplastic activity. c-Met inhibitor AMG 337 selectively binds to c-M...

LCRF-0004
(CAS: 1229611-73-7)

This active molecular is a selective RON receptor tyrosine kinase inhibitor. The RON receptor tyrosine kinase has been reported that it usually overexpressed in...

CAS 658084-23-2 SU11274

SU11274
(CAS: 658084-23-2)

SU11274 is a selective Met tyrosine kinase inhibitor with IC50 of 10 nM.

TAS-115
(CAS: 1190836-34-0)

This active molecular is a c-MET and VEGFR inhibitor which is selective and specific in vitro. In vivo studies, TAS-115 suppressed the progression of MET-inacti...

CAS 956905-27-4 PF-04217903

PF-04217903
(CAS: 956905-27-4)

PF-04136309 is an orally available human chemokine receptor 2 (CCR2) antagonist with potential immunomodulating and antineoplastic activities. Upon oral adminis...

CAS 1025720-94-8 BMS-777607

BMS-777607
(CAS: 1025720-94-8)

BMS-777607 is a novel prodrug of the dual Met/VEGFR-2 inhibitor.

CAS 905854-02-6 Tivantinib

Tivantinib
(CAS: 905854-02-6)

Tivantinib (ARQ-197) is an orally bioavailable small molecule inhibitor of c-Met with potential antineoplastic activity. c-Met inhibitor ARQ 197 binds to the c-...

SCR-1481B1
(CAS: 1174161-86-4)

SCR-1481B1, also known as c-Met inhibitor 2, is an effective inhibitor of MET kinase so that probably has anti-tumor activity. It is also found to be an inhibit...

CAS 928037-13-2 Golvatinib

Golvatinib
(CAS: 928037-13-2)

golvatinib (also known as E7050) is an orally bioavailable dual kinase inhibitor of c-Met (hepatocyte growth factor receptor) and VEGFR-2 (vascular endothelial ...

Glesatinib hydrochloride
(CAS: 1123838-51-6)

The hydrochloride salt form of Glesatinib, an inhibitor of tyrosine kinase, could be effectively targeting tumors that are driving to grow through MET and AXL r...

CAS 1206801-37-7 LY2801653 dihydrochloride

LY2801653 dihydrochloride
(CAS: 1206801-37-7)

LY2801653 is a type-II ATP competitive, slow-off inhibitor of MET tyrosine kinase with a dissociation constant (K(i)) of 2 nM, a pharmacodynamic residence time ...

CAS 1100598-32-0 Tepotinib

Tepotinib
(CAS: 1100598-32-0)

Tepotinib, also known as EMD 1214063 and MSC2156119, is an inhibitor of MET tyrosine kinase with potential antineoplastic activity. MET tyrosine kinase inhibito...

CAS 1401708-83-5 Dihexa

Dihexa
(CAS: 1401708-83-5)

Dihexa, an oligopeptide drug, is a stable bioavailable synthetic Hepatocyte growth factor (HGF) mimetic with potential to improve cognitive function in animal m...

CAS 1001917-37-8 MK-8033

MK-8033
(CAS: 1001917-37-8)

MK8033 is a novel and specific dual ATP competitive c-Met/Ron inhibitor (IC50=1 nM Wt c-Met) under investigation as a treatment for cancer.

CAS 877399-52-5 Crizotinib

Crizotinib
(CAS: 877399-52-5)

Crizotinib is an anti-cancer drug acting as an ALK (anaplastic lymphoma kinase) and ROS1 (c-ros oncogene 1) inhibitor.

CAS 849217-64-7 foretinib

foretinib
(CAS: 849217-64-7)

CAS 1437321-24-8 CEP-40783

CEP-40783
(CAS: 1437321-24-8)

CEP-40783 is an orally-active, nanomolar potent and highly kinase-selective Type II inhibitor of the AXL and c-Met RTK with IC50 values of 7 nM and 12 nM, respe...

CAS 1283000-43-0 MK-8033 hydrochloride

MK-8033 hydrochloride
(CAS: 1283000-43-0)

MK-8033 binds 3-fold more tightly to phosphorylated c-Met kinase domain (Kd= 3.2 nM) than to its unphosphorylated counterpart (Kd = 10.4 nM). Signigicantly, MK-...

CAS 1029712-80-8 Capmatinib

Capmatinib
(CAS: 1029712-80-8)

Capmatinib, also known as INCB28060 and INC280,  is an orally bioavailable inhibitor of the proto-oncogene c-Met (hepatocyte growth factor receptor [HGFR]) with...

CAS 1022150-57-7 SGX-523

SGX-523
(CAS: 1022150-57-7)

SGX523 is a novel, ATP-competitive kinase inhibitor remarkable for its exquisite selectivity for MET. SGX523 potently inhibited MET with an IC50 of 4 nmol/L an...

Chemical Structure

CAS 1206801-37-7 LY2801653 dihydrochloride

Quick Inquiry

Verification code

Featured Items