|Description||LY2409881 is a novel selective inhibitor of IKK2. It inhibited constitutively activated NF-κB, and caused concentration- and time-dependent growth inhibition and apoptosis in lymphoma cells. It suppressed the activity of the NF-κB subunit p65 in lymphoma cells treated by the HDAC inhibitor romidepsin, underlying a potential mechanism of the marked synergy observed of these two drugs.|
LY2409881 is a potent and selective IKK2 inhibitor with IC50 of 30 nM, >10-fold selectivity over IKK1 and other common kinases.
IKK-3 Inhibitor is a potent, selective, inhibitor of IKK-epsilon kinase and is inactive at IKK-α and IKK-β.
BI605906 is a novel pharmacological inhibitors of the IKK family. It inhibits IKKβ with an IC50 value of 380 nM when assayed at 0.1 mM ATP in vitro. It also inh...
MRT67307 is a potent and dual IKKϵ and TBK1 inhibitor with IC50 of 160 and 19 nM, respectively. It is an inhibitor for ULK1and ULK2 with IC50 value of 45 and 38...
IKK-2 inhibitor VIII
IKK-2 inhibitor VIII is a potent and selective IKK-2 inhibitor.
BMS-345541 is a highly selective inhibitor of the catalytic subunits of IKK-2 and IKK-1. It exhibits no effect against a panel of 15 other kinases and attenuate...
IKKε-IN-1 is a potent IKKε inhibitor; inhibit the in-situ ΙKΚ ε-mediated phosphorylation of IRF3 with an IC50 value of less than about 100 nM.
IKK16 is a selective IκB kinase (IKK) inhibitor for IKK-2( IC50=40 nM), IKK complex( IC50=70 nM) and IKK-1(IC50=2000 nM).
MLN120B is a potent and effective IKKbeta inhibitor. It is currently being explored for treatment of inflammatory diseases such as COPD and asthma.
SC-514 is an orally active, ATP-competitive IKK-2 inhibitor with IC50 of 3-12 μM, blocks NF-κB-dependent gene expression, does not inhibit other IKK isoforms or...
Bay 65-1942 R form
Bay 65-1942 R form is an ATP-competitive inhibitor that selectively targets IKKβ kinase.
AZD3264 is a novel IKK2 inhibitor.
PS-1145 is a selective IκB kinase (IKK) inhibitor (IC50 = 100 nM). PS1145 efficiently inhibited both basal and induced NF-kappaB activity in PC cells.
LY2409881 is a novel selective inhibitor of IKK2. It inhibited constitutively activated NF-κB, and caused concentration- and time-dependent growth inhibition an...
Bay 65-1942 hydrochloride
Bay 65-1942 hydrochloride is an ATP-competitive inhibitor that selectively targets IKKβ kinase.
IMD-0354 is an IKKβ inhibitor and blocks IκBα phosphorylation in NF-κβ pathway.
BAY 11-7082 completely and specifically abrogates NF-κB DNA binding, downregulating the NF-κB-inducible cytokine IL-6 and inducing apoptosis.
BMS-345541 is a highly selective inhibitor of the catalytic subunits of IKK-2 and IKK-1 with IC50 of 0.3 μM and 4 μM, respectively.
Bay 65-1942 free base
Bay 65-1942 is an ATP-competitive inhibitor that selectively targets IKKβ kinase.
TPCA-1 is an inhibitor of IKK-2 with IC50 of 17.9 nM, inhibits NF-κB pathway, exhibits 22-fold selectivity over IKK-1.