LY-518674 - CAS 425671-29-0
Catalog number:
425671-29-0
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C23H27N3O4
Molecular Weight:
409.48
COA:
Inquire
Targets:
PPAR
Description:
LY518674, a phenoxypropionic acid derivative, is a Potent and selective PPAR-alpha agonist produced a dose-dependent increase in serum HDL-c, resulting in 208 +/- 15% elevation at optimum dose.
Publictions citing BOC Sciences Products
  • >> More
Purity:
≥95%
Appearance:
Solid powder
Synonyms:
2-(4-(3-(2,5-dihydro-1-((4-methylphenyl)methyl)-5-oxo-1H-1,2,4-triazol-3-yl)propyl)phenoxy)-2-methyl-Propanoic acid;
Solubility:
Soluble in DMSO
Storage:
Store at -20 °C
MSDS:
Inquire
Application:
Peroxisome proliferator-activated receptor alpha agonists
Quality Standard:
Enterprise standard
Shelf Life:
As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly.
Quantity:
Milligrams-Grams
Boiling Point:
575.852ºC at 760 mmHg
Density:
1.21g/cm3
InChIKey:
PNHFDVSKDSLUFH-UHFFFAOYSA-N
InChI:
InChI=1S/C23H27N3O4/c1-16-7-9-18(10-8-16)15-26-22(29)24-20(25-26)6-4-5-17-11-13-19(14-12-17)30-23(2,3)21(27)28/h7-14H,4-6,15H2,1-3H3,(H,27,28)(H,24,25,29)
Canonical SMILES:
CC1=CC=C(C=C1)CN2C(=O)N=C(N2)CCCC3=CC=C(C=C3)OC(C)(C)C(=O)O
Current Developer:
Eli Lilly; Ligand Pharmaceuticals
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related PPAR Products


Pemafibrate
(CAS: 848259-27-8)

Pemafibrate is a Peroxisome proliferator-activated receptor alpha agonist. It can decrease the secretion of inflammatory markers without affecting cell prolifer...

CAS 1453-93-6 PROTOPANAXATRIOL

PROTOPANAXATRIOL
(CAS: 1453-93-6)

Protopanaxatriol is a dammarane-type tetracyclic triterpene sapogenins found in ginseng (Panax ginseng) and in notoginseng (Panax pseudoginseng). It may have a ...

CS-7017 monohydrate
(CAS: 1048002-36-3)

CS-7017 monohydrate is a peroxisome proliferator activated receptor gamma (PPAR) agonist. It is a potential therapy for thyroid cancer and liposarcoma. It is al...

CAS 22978-25-2 GW9662

GW9662
(CAS: 22978-25-2)

GW9662 is a potent, irreversible and selective PPARgamma antagonist, which prevented activation of PPARgamma and inhibited growth of human mammary tumour cell ...

GFT505
(CAS: 824932-88-9)

Elafibranor is an agonist of the peroxisome proliferator-activated receptor-α and peroxisome proliferator-activated receptor-δ. It induces resolution of nonalco...

CAS 213252-19-8 KRP297

KRP297
(CAS: 213252-19-8)

KRP297, also called as L4 10198 or MK 767, is a Peroxisome proliferator-activated receptor (PPAR) alpha and gamma (PPARα and PPARγ) agonist. With potential to t...

Saroglitazar
(CAS: 495399-09-2)

Saroglitazar is a novel peroxisome proliferator-activated receptor (PPAR) agonist with predominant PPARα and moderate PPARγ activity as a drug for the treatment...

CAS 161600-01-7 MCC-555

MCC-555
(CAS: 161600-01-7)

MCC-555, a thiazolidinedion derivative, has been found to be a PPAR agonist that was once studied as hyperglycaemic and hyperlipidaemic. The Phase II trial agai...

CAS 52214-84-3 Ciprofibrate

Ciprofibrate
(CAS: 52214-84-3)

Ciprofibrate is a peroxisome proliferator-activated receptor agonist.

CAS 112529-15-4 Pioglitazone HCl

Pioglitazone HCl
(CAS: 112529-15-4)

Pioglitazone HCl is a hydrochloride salt form of pioglitazone which is a cytochrome P450 (CYP)2C8 and CYP3A4 enzymes inhibitor for CYP2C8, CYP3A4 and CYP2C9 wit...

CAS 637-07-0 Clofibrate

Clofibrate
(CAS: 637-07-0)

Clofibrate is a fibric acid derivative used in the treatment of hyperlipoproteinemia type III and severe hypertriglyceridemia.

GSK7227
(CAS: 1067214-81-6)

GSK7227 is a novel class of PPARdelta partial agonists. It shows potent partial agonism of the PPARdelta target genes CPT1a and PDK4 in skeletal muscle cells.

CAS 108409-83-2 FH535

FH535
(CAS: 108409-83-2)

FH535 is a Wnt/β-catenin signaling inhibitor and also a dual PPARγ and PPARδ antagonist.

CAS 24136-23-0 Arhalofenate

Arhalofenate
(CAS: 24136-23-0)

Arhalofenateis, also known as JNJ-39659100 and MBX102, as an uricosuric agent it is a selective, partial PPAR-γ agonist.

CAS 50892-23-4 Pirinixic Acid

Pirinixic Acid
(CAS: 50892-23-4)

WY 14643 (Pirinixic Acid) is a potent peroxisome proliferator and activator of PPARα with EC50 of 1.5 μM.

CAS 25812-30-0 Gemfibrozil

Gemfibrozil
(CAS: 25812-30-0)

Gemfibrozil is the generic name for an oral drug used to lower lipid levels. It belongs to a group of drugs known as fibrates. It is most commonly sold as the b...

CAS 313516-66-4 T0070907

T0070907
(CAS: 313516-66-4)

T0070907 was identified as a potent and selective PPARgamma antagonist. T0070907 blocked PPARgamma function in both cell-based reporter gene and adipocyte diffe...

CAS 539813-69-9 PPAR agonist 1

PPAR agonist 1
(CAS: 539813-69-9)

An agonist of PPAR α and PPAR γ

CAS 810677-36-2 PPARα-MO-1

PPARα-MO-1
(CAS: 810677-36-2)

A potent PPARα modulator

CAS 223132-38-5 Inolitazone dihydrochloride

Inolitazone dihydrochloride
(CAS: 223132-38-5)

In vitro, the IC50 for growth inhibition is approximately 0.8 nM while anaplastic thyroid carcinoma (ATC) tumor growth was inhibited three- to fourfold in nude ...

Chemical Structure

CAS 425671-29-0 LY-518674

Quick Inquiry

Verification code

Featured Items