LY-411575 isomer 1 - CAS 209984-58-7
Catalog number:
209984-58-7
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C26H23F2N3O4
Molecular Weight:
479.48
COA:
Inquire
Targets:
γ-secretase
Description:
LY-411575 isomer 1, is an isomer of LY411575, which is a potent, cell-permeable γ-secretase inhibitor (IC50= 0.078 nM/0.082 nM (in membrane-assay/in cell-basedγ-secretase assays)) and also inhibits Notch clevage (IC50= 0.41 nM). Phase III
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Brife Description:
Inhibits γ-secretase and Notch clevage
Appearance:
White to off-white solid
Synonyms:
(2S)-2-[[(2R)-2-(3,5-difluorophenyl)-2-hydroxyacetyl]amino]-N-[(7S)-5-methyl-6-oxo-7H-benzo[d][1]benzazepin-7-yl]propanamide; LY-411575 (isomer 1); HY-50752A; ZINC38382410; CS-3132; 209984-58-7
Solubility:
Soluble to 96 mg/mL in DMSO
Storage:
Store in a cool and dry place and at 0 - 4℃ for short term (days to weeks) or -39℃ for long term (months to years).
MSDS:
Inquire
Boiling Point:
836.0±65.0℃ at 760 Torr
Density:
1.40±0.1 g/cm3
InChIKey:
ULSSJYNJIZWPSB-AETJINEWSA-N
InChI:
1S/C26H23F2N3O4/c1-14(29-25(34)23(32)15-11-16(27)13-17(28)12-15)24(33)30-22-20-9-4-3-7-18(20)19-8-5-6-10-21(19)31(2)26(22)35/h3-14,22-23,32H,1-2H3,(H,29,34)(H,30,33)/t14-,22-,23+/m0/s1
Canonical SMILES:
CC(C(=O)NC1C2=CC=CC=C2C3=CC=CC=C3N(C1=O)C)NC(=O)C(C4=CC(=CC(=C4)F)F)O
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Chemical Structure

CAS 209984-58-7 LY-411575 isomer 1

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