|Description||LY-411575 isomer 1, is an isomer of LY411575, which is a potent, cell-permeable γ-secretase inhibitor (IC50= 0.078 nM/0.082 nM (in membrane-assay/in cell-basedγ-secretase assays)) and also inhibits Notch clevage (IC50= 0.41 nM). Phase III|
|Brife Description||Inhibits γ-secretase and Notch clevage|
|Appearance||White to off-white solid|
|Synonyms||(2S)-2-[[(2R)-2-(3,5-difluorophenyl)-2-hydroxyacetyl]amino]-N-[(7S)-5-methyl-6-oxo-7H-benzo[d]benzazepin-7-yl]propanamide; LY-411575 (isomer 1); HY-50752A; ZINC38382410; CS-3132; 209984-58-7|
|Solubility||Soluble to 96 mg/mL in DMSO|
|Storage||Store in a cool and dry place and at 0 - 4℃ for short term (days to weeks) or -39℃ for long term (months to years).|
|Boiling Point||836.0±65.0℃ at 760 Torr|
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LY-411575 isomer 1
LY-411575 isomer 1, is an isomer of LY411575, which is a potent, cell-permeable γ-secretase inhibitor (IC50= 0.078 nM/0.082 nM (in membrane-assay/in cell-based...
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