(±)-LY 367385 - CAS 198419-90-8
Category: Inhibitor
Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Molecular Formula:
C10H11NO4
Molecular Weight:
209.2
COA:
Inquire
Targets:
mGluR
Description:
(±)-LY367385 is a selective mGlu1a antagonist.
Brife Description:
mGlu1a antagonist
Purity:
98%
Synonyms:
4-[Amino(carboxy)methyl]-3-methylbenzoic acid
MSDS:
Inquire
InChIKey:
SGIKDIUCJAUSRD-UHFFFAOYSA-N
InChI:
InChI=1S/C10H11NO4/c1-5-4-6(9(12)13)2-3-7(5)8(11)10(14)15/h2-4,8H,11H2,1H3,(H,12,13)(H,14,15)
Canonical SMILES:
CC1=C(C=CC(=C1)C(=O)O)C(C(=O)O)N
1.Persistent receptor activity underlies group I mGluR-mediated cellular plasticity in CA3 neuron.
Young SR;Chuang SC;Zhao W;Wong RK;Bianchi R J Neurosci. 2013 Feb 6;33(6):2526-40. doi: 10.1523/JNEUROSCI.3338-12.2013.
Plastic changes in cortical activities induced by group I metabotropic glutamate receptor (mGluR) stimulation include epileptogenesis, expressed in vitro as the conversion of normal neuronal activity to persistent, prolonged synchronized (ictal) discharges. At present, the mechanism that maintains group I mGluR-induced plasticity is not known. We examined this issue using hippocampal slices from guinea pigs and mice. Agonist [(S)-3,5-dihydroxyphenylglycine (DHPG), 30-50 μm)] stimulation of group I mGluRs induces persistent prolonged synchronized (ictal-like) discharges in CA3 that are associated with three identified excitatory cellular responses-suppression of spike afterhyperpolarizations, activation of a voltage-dependent cationic current, and increase in neuronal input resistance. Persistent prolonged synchronized discharges and the underlying excitatory cellular responses maintained following induction were reversibly blocked by mGluR1 antagonists [(S)-+-α-amino-4-carboxy-2-methylbenzeneacetic acid (LY 367385), 50, 100 μm; CPCCOEt (hydroxyimino)cyclopropa[b]chromen-1a-carboxylate ethyl ester, 100 μm], and to a lesser extent by the mGluR5 antagonist MPEP [2-methyl-6-(phenylethynyl)pyridine hydrochloride, 50 μm].
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related mGluR Products


CAS 1216398-09-2 YM 298198 hydrochloride

YM 298198 hydrochloride
(CAS: 1216398-09-2)

YM 298198 hydrochloride is a non-competitive and high affinity antagonist at mGlu1 receptors (Ki = 19 nM). YM 298198 is inactive at other mGlu receptor subtypes...

CAS 302841-86-7 Ro 01-6128

Ro 01-6128
(CAS: 302841-86-7)

Ro 01-6128 is a positive allosteric modulator of mGluR1 that potentiates glutamate-induced calcium release (EC50 = 104 nM). Ro 01-6128 activates ERK1/2 phosphor...

CAS 157381-42-5 MAP4

MAP4
(CAS: 157381-42-5)

MAP4 is a selective group III metabotropic glutamate receptor (mGluR) antagonist in some electrophysiological systems. It acts as a group II/group III agonist i...

CAS 2018282-44-3 BMT-145027

BMT-145027
(CAS: 2018282-44-3)

BMT-145027 is a potent mGluR5 PAM without inherent agonist activity with an EC50 of 47 nM. BMT-145027 is a non-MPEP site PAM to demonstrate in vivo efficacy.

CAS 170846-74-9 CHPG

CHPG
(CAS: 170846-74-9)

CHPG is a selective metabotropic glutamate 5 (mGlu5) receptor agonist, and it is inactive in CHO cells. CHPG potentiates NMDA-induced depolarizations in rat hip...

CAS 327056-26-8 AZD 9272

AZD 9272
(CAS: 327056-26-8)

AZD 9272 is a potent, long-acting and selective nervous system penetrant mGlu5 antagonist with IC50 values of 2.6 and 7.6 nM for rat and human receptors, respec...

FITM
(CAS: 932737-65-0)

FITM is a potent mGlu1 inhibitor (Ki = 2.5 nM) with great selectivity that does not disrupt mGlu5.

CAS 117857-93-9 L-CCG-l

L-CCG-l
(CAS: 117857-93-9)

L-CCG-l is a potent group II metabotropic glutamate receptor (mGluR) agonist.

Chemical Structure

CAS 198419-90-8 (±)-LY 367385

Quick Inquiry

Verification code

Featured Items