(±)-LY 367385 - CAS 198419-90-8
Category: Inhibitor
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Molecular Formula:
Molecular Weight:
(±)-LY367385 is a selective mGlu1a antagonist.
Brife Description:
mGlu1a antagonist
4-[Amino(carboxy)methyl]-3-methylbenzoic acid; LY 367385; LY-367385; LY367385
Canonical SMILES:
1.Persistent receptor activity underlies group I mGluR-mediated cellular plasticity in CA3 neuron.
Young SR;Chuang SC;Zhao W;Wong RK;Bianchi R J Neurosci. 2013 Feb 6;33(6):2526-40. doi: 10.1523/JNEUROSCI.3338-12.2013.
Plastic changes in cortical activities induced by group I metabotropic glutamate receptor (mGluR) stimulation include epileptogenesis, expressed in vitro as the conversion of normal neuronal activity to persistent, prolonged synchronized (ictal) discharges. At present, the mechanism that maintains group I mGluR-induced plasticity is not known. We examined this issue using hippocampal slices from guinea pigs and mice. Agonist [(S)-3,5-dihydroxyphenylglycine (DHPG), 30-50 μm)] stimulation of group I mGluRs induces persistent prolonged synchronized (ictal-like) discharges in CA3 that are associated with three identified excitatory cellular responses-suppression of spike afterhyperpolarizations, activation of a voltage-dependent cationic current, and increase in neuronal input resistance. Persistent prolonged synchronized discharges and the underlying excitatory cellular responses maintained following induction were reversibly blocked by mGluR1 antagonists [(S)-+-α-amino-4-carboxy-2-methylbenzeneacetic acid (LY 367385), 50, 100 μm; CPCCOEt (hydroxyimino)cyclopropa[b]chromen-1a-carboxylate ethyl ester, 100 μm], and to a lesser extent by the mGluR5 antagonist MPEP [2-methyl-6-(phenylethynyl)pyridine hydrochloride, 50 μm].
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CAS 198419-90-8 (±)-LY 367385

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