|Description||LY 215490, a decahydroisoquinoline derivative, has been found to be an AMPA receptor antagonist that could be a neuroprotective agent in the study of focal ischaemia.|
|Synonyms||LY-293559; LY 215490; LY-215490; CHEMBL70937; SCHEMBL3678843; ZINC5760; (3R,4aS,6S,8aS)-6-[2-(2H-tetrazol-5-yl)ethyl]-1,2,3,4,4a,5,6,7,8,8a-decahydroisoquinoline-3-carboxylic acid|
|Storage||Store in a cool and dry place and at 0 - 4 °C for short term (days to weeks) or -20 °C for long term (months to years).|
|Quality Standard||In-house standard|
This active molecular is an AMPA receptor antagonist which blocks AMPA receptors in 10-20µM concentrations. It is also a Glutamate receptor antagonist. NBQX was...
LY 215490, a decahydroisoquinoline derivative, has been found to be an AMPA receptor antagonist that could be a neuroprotective agent in the study of focal isch...
It is one of a series of AMPA modulators for the potential treatment of Alzheimer's disease, schizophrenia, and mild cognitive impairment (MCI). An ampakine dru...
4-Phenyl-2-pyrrolidone-1-acetamide is a GABA derivative that exhibited apparent immunocorrection properties during immunosuppression induced by cyclophosphamide...
GYKI-47261 is a non-competitive AMPA receptor antagonist (IC50 = 2.5 μM) and a CYP2E1 inducer. GYKI-47261 shows broad spectrum anticonvulsive activity and neuro...
IDRA-21, an analog of cyclothiazide, inhibits AMPA receptor desensitization and enhances cognition by a related mechanism. IDRA-21 inhibits synaptic and extrasy...
NS-1209, an AMPA/GluR5 receptor antagonist, is a antiepileptic drug candidate currently under clinical trials.
GYKI-53784, a dioxolbenzene derivative, has been found to be a AMPA receptor antagonist that could block excitotoxicity and decrease auditory nerve activity at ...
CMPDA is a positive allosteric modulator of AMPA receptors. Binds at the modulator binding pocket located at the interdimer interface and the clamshell hinges.
LY-326325, a decahydroisoquinaline derivative, has been found to be an AMPA receptor antagonist and was once studied for neuroprotection.
A poliamine amide as potent Spermidine uptake inhibitor.
Org-26576 is a positive allosteric modulator of AMPA receptor. Org-26576 increases the anteroventral and laterodorsal thalamus, cingulate cortex, dentate gyrus ...
EGIS-8332 potently decreased AMPA and quisqualate induced LDH release (IC50 = 5.2 ± 0.4 and 7.4 ± 1.3 μM, respectively) from the cells. The inhibition of the AM...
CP 465022, with anticonvulsant activity, is a potent, brain penetrant, orally active and selective noncompetitive AMPA receptor antagonist (IC50 = 25 nM in rat ...
ZK200775 hydrate(Fanapanel; MPQX) is a highly selective AMPA/kainate antagonist with little activity against NMDA; have Ki values of 3.2 nM, 100 nM, and 8.5 &mu...
GYKI-53405 is a noncompetitive α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPA receptor) antagonist. It can bind to Xenopus brain membranes ...
Talampanel, also known as LY300164 and GYKI-53773, is a glutamate receptor inhibitor with anti-seizure activity. Talampanel is also an orally active, potent an...
GYKI 53655 is a selective AMPA receptor antagonist with anticonvulsant activity.
Noopept is a nootropic and neuroprotective drug that normalizes the balance of the pro- and antioxidant systems. Noopept modulates a variety of physiological fu...
GYKI-52466 is a non-competitive AMPA receptor antagonist. It belongs to 2,3-benzodiazepine that acts as an ionotropic glutamate receptor antagonist. It has anti...