|Description||LY-293284 is a Serotonin 1A receptor agonist developed by Eli Lilly. It is a selective 5-HT1A receptor full agonist. LY-293284 is far more selective for 5-HT1A with over 1000x selectivity over other serotonin receptor subtypes and other targets. No development was reported for the treatment of Anxiety disorders and Major depressive disorder.|
|Solubility||Soluble in DMSO|
|Application||Anxiety disorders; Major depressive disorder|
|Quality Standard||In-house standard|
|Shelf Life||2 month in rt, long time|
|Current Developer||Eli Lilly; Nonindustrial source|
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LY 344864 hydrochloride
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4F 4PP oxalate
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WAY 100135 dihydrochloride
WAY 100135 dihydrochloride is a selective 5-HT1A antagonist (IC50 = 15 nM).
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LY 393558 is a 5-HT reuptake inhibitor with pIC50 value of 8.48. It is also a dual 5-HT1B/1D receptor antagonist with pKB values of 9.05 and 8.98 respectively.