LY-2562175 - CAS 1103500-20-4
Catalog number: 1103500-20-4
Category: Inhibitor
Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Molecular Formula:
C28H27Cl2N3O4
Molecular Weight:
540.44
COA:
Inquire
Targets:
FXR
Description:
LY2562175 is a potent and selective FXR agonist in vitro. It has robust lipid modulating properties, lowering LDL and triglycerides while raising HDL in preclinical species. It was developed by Eli Lilly and Company and in clinic phase 1 trials with no progress.
Purity:
>98%
Appearance:
Solid powder
Synonyms:
LY2562175;6-(4-((5-Cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methoxy)piperidin-1-yl)-1-methyl-1H-indole-3-carboxylic acid
Solubility:
10 mM in DMSO
Storage:
-20°C Freezer
MSDS:
Inquire
Application:
LY2562175 has robust lipid modulating properties, lowering LDL and triglycerides while raising HDL in preclinical species.
Quality Standard:
In-house standard
Shelf Life:
2 month in rt, long time
Quantity:
Milligrams-Grams
Boiling Point:
740.1±60.0 °C | Condition: Press: 760 Torr
Density:
1.48±0.1 g/cm3 | Condition: Temp: 20 °C Press: 760 Torr
InChIKey:
RPVDFHPBGBMWID-UHFFFAOYSA-N
InChI:
InChI=1S/C28H27Cl2N3O4/c1-32-14-20(28(34)35)19-8-7-17(13-24(19)32)33-11-9-18(10-12-33)36-15-21-26(31-37-27(21)16-5-6-16)25-22(29)3-2-4-23(25)30/h2-4,7-8,13-14,16,18H,5-6,9-12,15H2,1H3,(H,34,35)
Canonical SMILES:
CN1C=C(C2=C1C=C(C=C2)N3CCC(CC3)OCC4=C(ON=C4C5=C(C=CC=C5Cl)Cl)C6CC6)C(=O)O
Current Developer:
LY2562175 was developed by Eli Lilly and Company and in clinic phase 1 trials with no progress.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related FXR Products


PX 102
(CAS: 1268245-19-7)

PX102 is a Farnesoid X-activated Receptor (FXR) agonist originated by Phenex Pharmaceuticals. PX102 demonstrated potent plasma cholesterol-lowering activity tha...

CAS 629664-81-9 Turofexorate Isopropyl

Turofexorate Isopropyl
(CAS: 629664-81-9)

Turofexorate Isopropyl is a highly potent, selective, and orally active farnesoid X receptor (FXR) agonist.

CAS 474-25-9 Chenodeoxycholic Acid

Chenodeoxycholic Acid
(CAS: 474-25-9)

Chenodeoxycholic Acid is a naturally occurring human bile acid.Chenodeoxycholic acid has been used as medical therapy to dissolve gallstones.

DY-268
(CAS: 1609564-75-1)

DY-268, a pyrazol carboamide derivative, has been found to be a FXR antagonist that could be significant in studies of the biological activities of FXR. IC50: 7...

EP-024297

EP-024297 is a novel agonist of farnesoid X receptor (FXR). Study in Chinese hamster ovary cells showed that it is 20000-fold more potent than obeticholic acid ...

CAS 1000403-03-1 INT-767

INT-767
(CAS: 1000403-03-1)

INT-767, a steride compound, has been found to be a inhibitor of FXR and TGF5 and could have probable effect against some liver and metabolic diseases. It was j...

LY-2562175
(CAS: 1103500-20-4)

LY2562175 is a potent and selective FXR agonist in vitro. It has robust lipid modulating properties, lowering LDL and triglycerides while raising HDL in preclin...

CAS 1612191-86-2 BAR502

BAR502
(CAS: 1612191-86-2)

BAR502 is a dual FXR and GPBAR1 agonist (IC50= 2 μM and 0.4 μM for FXR and GPBAR1, respectively).

CAS 39025-23-5 Z-Guggulsterone

Z-Guggulsterone
(CAS: 39025-23-5)

Z-Guggulsterone is a broad spectrum steroid receptor ligand that acts as a mineralocorticoid, progesterone and glucocorticoid receptor antagonist (Ki = 37, 224 ...

PX-102
(CAS: 1268244-85-4)

PX-102, also known as PX-20606, is a farnesoid X-activated receptor (FXR) agonist. PX-102 is indicated to be active in lowering plasma cholesterol, and ameliora...

CAS 574013-66-4 Fexaramine

Fexaramine
(CAS: 574013-66-4)

Fexaramine is a small molecule farnesoid X receptor agonist with 100-fold increased affinity relative to natural compounds.

CAS 278779-30-9 GW4064

GW4064
(CAS: 278779-30-9)

GW4064 is a selective non-steroidal agonist of farnesoid X receptor (FXR) with EC50 value of 15 nM.

CAS 1198085-23-2 PX 20350

PX 20350
(CAS: 1198085-23-2)

PX 20350 is a farnesoid X receptor (FXR) agonist with enhanced affinity and efficacy (12 nM and 109% (compared to GW 4064)) in FXR FRET assay and full length FX...

CAS 459789-99-2 Obeticholic Acid

Obeticholic Acid
(CAS: 459789-99-2)

Obeticholic Acid is a potent and selective farnesoid X receptor (FXR) agonist with EC50 of 99 nM. It reduced liver fat and reverted cholestasis in a rat model.

CAS 1383816-29-2 Tropifexor

Tropifexor
(CAS: 1383816-29-2)

Tropifexor is a novel highly potent agonist of farnesoid X receptor (FXR), which regulates bile acid metabolism and signaling. FXR activated by Tropifexor can i...

Quick Inquiry

Verification code

Featured Items