LY-2562175 - CAS 1103500-20-4
Catalog number: 1103500-20-4
Category: Inhibitor
Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Molecular Formula:
C28H27Cl2N3O4
Molecular Weight:
540.44
COA:
Inquire
Targets:
FXR
Description:
LY2562175 is a potent and selective FXR agonist in vitro. It has robust lipid modulating properties, lowering LDL and triglycerides while raising HDL in preclinical species. It was developed by Eli Lilly and Company and in clinic phase 1 trials with no progress.
Purity:
>98%
Appearance:
Solid powder
Synonyms:
LY2562175; LY 2562175; LY-2562175;6-(4-((5-Cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methoxy)piperidin-1-yl)-1-methyl-1H-indole-3-carboxylic acid
Solubility:
10 mM in DMSO
Storage:
-20°C Freezer
MSDS:
Inquire
Application:
LY2562175 has robust lipid modulating properties, lowering LDL and triglycerides while raising HDL in preclinical species.
Quality Standard:
In-house standard
Shelf Life:
2 month in rt, long time
Quantity:
Milligrams-Grams
Boiling Point:
740.1±60.0 °C | Condition: Press: 760 Torr
Density:
1.48±0.1 g/cm3 | Condition: Temp: 20 °C Press: 760 Torr
InChIKey:
RPVDFHPBGBMWID-UHFFFAOYSA-N
InChI:
InChI=1S/C28H27Cl2N3O4/c1-32-14-20(28(34)35)19-8-7-17(13-24(19)32)33-11-9-18(10-12-33)36-15-21-26(31-37-27(21)16-5-6-16)25-22(29)3-2-4-23(25)30/h2-4,7-8,13-14,16,18H,5-6,9-12,15H2,1H3,(H,34,35)
Canonical SMILES:
CN1C=C(C2=C1C=C(C=C2)N3CCC(CC3)OCC4=C(ON=C4C5=C(C=CC=C5Cl)Cl)C6CC6)C(=O)O
Current Developer:
LY2562175 was developed by Eli Lilly and Company and in clinic phase 1 trials with no progress.
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