LY 235959 - CAS 137433-06-8
Catalog number:
137433-06-8
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C11H20NO5P
Molecular Weight:
277.26
COA:
Inquire
Targets:
NMDA Receptor
Description:
LY 235959 is a competitive N-Methyl-D-Aspartate Receptor antagonist originated by Eli Lilly. No development was reported for treatment of Movement disorders in USA . Research for treatment of Alzheimer's disease was discontinued.
Publictions citing BOC Sciences Products
  • >> More
Purity:
98%
Appearance:
White Solid
Synonyms:
(3S)-(3-alpha-4-alpha,alpha-6-beta-8-alpha,alpha)-Decahydro-6-(phosphonomethyl)-3-isoquinolinecarboxylic acid;LY 235959
Solubility:
Soluble in DMSO
Storage:
-20°C Freezer
MSDS:
Inquire
Application:
Alzheimer's disease;Movement disorders
Quality Standard:
In-house standard
Shelf Life:
2 month in rt, long time
Quantity:
Milligrams-Grams
Density:
1.339g/cm3
InChIKey:
STIRHCNEGQQBOY-QEYWKRMJSA-N
InChI:
1S/C11H20NO5P/c13-11(14)10-4-9-3-7(6-18(15,16)17)1-2-8(9)5-12-10/h7-10,12H,1-6H2,(H,13,14)(H2,15,16,17)/t7-,8-,9+,10-/m0/s1
Canonical SMILES:
C1C[C@H]2CN[C@@H](C[C@H]2C[C@H]1CP(=O)(O)O)C(=O)O
Current Developer:
Originator Eli Lilly
1.Effects of NMDA receptor antagonists on morphine tolerance: a c-Fos study in the lumbar spinal cord of the rat.
Le Guen S1, Catheline G, Besson JM. Eur J Pharmacol. 1999 May 28;373(1):1-11.
This study investigated the contribution of NMDA receptors to the development of tolerance to the antinociceptive properties of morphine at the level of the spinal cord dorsal horn. The expression of c-Fos protein following intraplantar (i.pl.) injection of carrageenin (6 mg/150 microl of saline) was used. In naive rats, acute intravenous (i.v.) administration of morphine (3 mg/kg) decreased the total number per section of Fos-Like-Immunoreactive (Fos-LI) neurons by 51%, observed at 2 h after injection of carrageenin. In tolerant rats, acute morphine did not significantly modify the total number of Fos-like immunoreactive neurons/section. In rats receiving chronic morphine and chronic injections of the non-competitive ((+)-MK 801 maleate: (5R,10S)-(+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,1 0-imine) or the competitive (LY 235959: [3S-(3alpha,4a alpha,6beta,8a alpha)]-Decahydro-6-(phosphonomethyl)-3-isoquinolinecarboxylic+ ++ acid) NMDA receptor antagonists, only partial tolerance to the acute effects of morphine were observed (decrease of 42% and 38%, respectively).
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related NMDA Receptor Products


LY 233536
(CAS: 136845-59-5)

LY 233536 is a novel competitive N-methyl-D-aspartate (NMDA) receptor antagonist, but few detailed information has been published yet.

CAS 121917-57-5 (-)-MK 801 Maleate

(-)-MK 801 Maleate
(CAS: 121917-57-5)

MK-801 is a potent, selective and non-competitive NMDA receptor antagonist with Kd of 37.2 nM in rat brain membranes.

CAS 142326-59-8 L-701,324

L-701,324
(CAS: 142326-59-8)

L-701,324 is a selective antagonist at the glycine site of the NMDA glutamate receptor. L-701,324 shows a beneficial action in the animal model of parkinsonian ...

LY 257883
(CAS: 118183-22-5)

LY 257883, also known as PPPA, is a competitive NMDA receptor antagonist which displays moderate selectivity for NR2A-containing receptors. Ki values are 0.13μM...

CAS 77086-22-7 (-)-MK-801 maleate

(-)-MK-801 maleate
(CAS: 77086-22-7)

(-)-MK-801 maleate is a potent, selective and non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist with Ki of 30.5 nM that acts at the NMDA receptor-...

CAS 23210-58-4 Ifenprodil Tartrate

Ifenprodil Tartrate
(CAS: 23210-58-4)

Ifenprodil is an atypical noncompetitive antagonist at the NMDA receptor, it interacts with high affinity at a homogeneous population of NMDA receptors in neona...

CAS 130798-51-5 MDL 29951

MDL 29951
(CAS: 130798-51-5)

CAS 768-94-5 Amantadine

Amantadine
(CAS: 768-94-5)

Amantadine is can be used as an antiviral and an antiparkinsonian drug. It is a NMDA receptor antagonist. Amantadine is also a useful building block in organic ...

Cgp 39653
(CAS: 132472-31-2)

Cgp 39653 is a competitive N-Methyl-D-aspartate (NMDA) receptor antagonist. CGP 39653 can selectively bins to the NMDA receptor as an antagonist with high affin...

CAS 253450-09-8 Besonprodil

Besonprodil
(CAS: 253450-09-8)

Besonprodil, a benzimidazolone bioisostere, is an NMDA antagonist that selective for the NR2B subunit.

CGP 43487
(CAS: 146388-56-9)

CGP 43487 has been found to be a NMDA receptor antagonist and was once studied about its influenment of dopaminergic function as a supplement in the treatment o...

Dioxadrol hydrochloride
(CAS: 631-06-1)

Dioxadrol hydrochloride has been found to be an NMDA antagonist and is used as a dissociative anaesthetic drug. It produces similar effects to PCP in animals. I...

CAS 81338-23-0 D-AP7

D-AP7
(CAS: 81338-23-0)

D-AP7 is a selective NMDA receptor antagonist that inhibits the glutamate binding site and activation of NMDA receptor. It is the 8-Bromo-cGMP and the more acti...

PEAQX
(CAS: 459836-30-7)

PEAQX(NVP-AAM 077) is a potent and orally active NMDA antagonist with a 15-fold preference for human NMDA receptors with the 1A/2A(IC50=270 nM), rather than 1A/...

GV-196771
(CAS: 166974-22-7)

GV-196771, an indole derivative, has been found to be a non-opioid analgesic agent which is also a NMDA antagonist binds to glycine-binding site and was once st...

CP-283097
(CAS: 138047-56-0)

CP-283097 is NR2B N-Methyl-D-Aspartate receptor antagonist originated by Pfizer. Preclinical trials for the treatment of Migraine and Neurodegenerative disorder...

Rapastinel
(CAS: 117928-94-6)

Rapastinel, a brain penetrable tetrapeptide, could be a partial agonist of NMDA receptor. It was already finished the Phase II trial for acting as an antidepres...

Felbamate hydrate
(CAS: 1177501-39-1)

The hydrate of Felbamate which is an effective anticonvulsant agent. It was found to be clinically active for probably restraining the effectivity of NMDA.

AM-36
(CAS: 199467-52-2)

AM-36 is a potent blocker of batrachotoxinin (BTX)-sensitive Na+ channel binding in rat brain homogenates with an IC50 of 0.28 microM. As a unique neuroprotecti...

Apimostinel
(CAS: 1421866-48-9)

Apimostinel is a selective partial agonist of an allosteric site of the glycine site of the NMDA receptor complex under investigation by Naurex. Its mechanism o...

Chemical Structure

CAS 137433-06-8 LY 235959

Quick Inquiry

Verification code

Featured Items