|Description||LY-221501, a piperidine derivative, has been found to be a NMDA receptor antagonist.|
|Synonyms||LY-221501; Cis-4-(3-Carboxyprop-1-yl)piperidine-2-carboxylic acid; 145512-35-2; LY 221501; 4-Piperidinebutanoicacid, 2-carboxy-, (2R,4S)-; AC1L31HC|
|Storage||Store in a cool and dry place and at 0 - 4 °C for short term (days to weeks) or -20 °C for long term (months to years).|
|Quality Standard||In-house standard|
Besonprodil, a benzimidazolone bioisostere, is an NMDA antagonist that selective for the NR2B subunit.
AM-36 is a potent blocker of batrachotoxinin (BTX)-sensitive Na+ channel binding in rat brain homogenates with an IC50 of 0.28 microM. As a unique neuroprotecti...
CIQ is a derivative of tetrahydroisoquinoline acts as subunit-selective potentiator of NMDA receptors containing the NR2C (EC50=2.7 μM) or NR2D (EC50=2.8 μM) su...
Ifenprodil is an atypical noncompetitive antagonist at the NMDA receptor, it interacts with high affinity at a homogeneous population of NMDA receptors in neona...
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CP-283097 is NR2B N-Methyl-D-Aspartate receptor antagonist originated by Pfizer. Preclinical trials for the treatment of Migraine and Neurodegenerative disorder...
TCN 237 dihydrochloride
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LY 233536 is a novel competitive N-methyl-D-aspartate (NMDA) receptor antagonist, but few detailed information has been published yet.
Cgp 39551 is a selective and competitive N-methyl-D-aspartate (NMDA) receptor antagonist originated by Novartis. Ki is 310 nM for inhibition of [3H]-CPP binding...
CGP 43487 has been found to be a NMDA receptor antagonist and was once studied about its influenment of dopaminergic function as a supplement in the treatment o...
Memantine is the first in a novel class of Alzheimer's disease medications acting on the glutamatergic system by blocking NMDA receptors.It is also a CYP2B6 and...
LY 235959 is a competitive N-Methyl-D-Aspartate Receptor antagonist originated by Eli Lilly. No development was reported for treatment of Movement disorders in ...
Mephenesin is an NMDA receptor antagonist, is a centrally acting muscle relaxant.
(-)-MK-801 maleate is a potent, selective and non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist with Ki of 30.5 nM that acts at the NMDA receptor-...
GV-196771, an indole derivative, has been found to be a non-opioid analgesic agent which is also a NMDA antagonist binds to glycine-binding site and was once st...
D-AP7 is a selective NMDA receptor antagonist that inhibits the glutamate binding site and activation of NMDA receptor. It is the 8-Bromo-cGMP and the more acti...
Orphenadrine Citrate is a skeletal muscle relaxant, it acts in the central nervous system to produce its muscle relaxant effects.
Dextromethorphan hydrobromide hydrate
Dextromethorphan, a dextratrorotatory morphinan, is a non-competitive, low affinity NMDA receptor antagonist.
LY 257883, also known as PPPA, is a competitive NMDA receptor antagonist which displays moderate selectivity for NR2A-containing receptors. Ki values are 0.13μM...