LY 221068 - CAS 132392-39-3
Catalog number: 132392-39-3
Category: Inhibitor
Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Molecular Formula:
C20H30N2O2S
Molecular Weight:
362.54
COA:
Inquire
Targets:
Lipoxygenases (LOXs)
Description:
LY 221068 is a Lipoxygenase inhibitor originated by Eli Lilly. It is a potent antioxidant with antiinflammatory properties. But no development was reported for Rheumatic disorders in USA.
Purity:
98%
Appearance:
Powder
Synonyms:
5-((3,5-Bis(1,1,-dimethylethyl)-4-hydroxyphenyl)methylene)-3-(dimethylamino)-4-thiazolidinone
Solubility:
Soluble in DMSO
Storage:
-20°C Freezer
MSDS:
Inquire
Application:
Rheumatic disorders
Quality Standard:
In-house standard
Shelf Life:
2 month in rt, long time
Quantity:
Milligrams-Grams
InChIKey:
DNXBQWAKVPAADQ-WJDWOHSUSA-N
InChI:
1S/C20H30N2O2S/c1-19(2,3)14-9-13(10-15(17(14)23)20(4,5)6)11-16-18(24)22(12-25-16)21(7)8/h9-11,23H,12H2,1-8H3/b16-11-
Canonical SMILES:
S1CN(C(\C1=C\c1cc(c(c(c1)C(C)(C)C)O)C(C)(C)C)=O)N(C)C
Current Developer:
Originator Eli Lilly
1.Inhibition of IL-1 induced articular inflammation of rats by 4-aminothiazolidines, LY 221068 and LY 269415.
Chandrasekhar S;Panetta JA;Bendele AM Agents Actions. 1994 Aug;42(1-2):67-70.
LY 221068 and LY 269415 are representative compounds from a chemical series of 4-aminothiazolidines, with potent antioxidant properties in vitro. We have evaluated these two compounds in a rat model of articular inflammation caused by the administration of recombinant human IL-1 beta into the knee joints. IL-1 injection into the knee joints has been shown to cause a complex series of changes resulting in synovitis, mesenchymal proliferation, and subchondral bone and cartilage erosion. The inflammatory response of the knee joint was measured by determining the changes in the joint swelling and also by histological evaluation of the knee joints. Rats pretreated (p.o.) with 10-25 mg/kg of either of these compounds (4 h prior to IL-1 injection) displayed greatly reduced soft tissue swelling with an IC50 of 7.5 mg/kg. Evaluation of histological lesions revealed, however, that LY 269415 (IC50 of 10 mg/kg) was more potent than LY 221068 (IC50 of 25 mg/kg) in reducing the severity of histological changes. The results demonstrate that antioxidants of this chemical series either directly or indirectly display anti-inflammatory properties and could be beneficial as therapeutic agents in inflammatory arthritis.
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CAS 132392-39-3 LY 221068

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