|Description||LUF6000 is an allosteric modulator of the human A3 adenosine receptor (AR). It was found to be an allosteric enhancer of Emax. It exerted an Emax-enhancing effect at a concentration of 0.1 microM or higher. It was shown to increase the Emax of Cl-IB-MECA and other low-efficacy agonists to a larger extent than that of the high-efficacy agonist NECA. It converted a nucleoside A3 AR antagonist MRS542. It has anti-inflammatory effect.|
|Solubility||10 mM in DMSO|
|Application||LUF6000 has anti-inflammatory effect.|
|Quality Standard||In-house standard|
|Shelf Life||2 month in rt, long time|
|Boiling Point||650.5±55.0 °C | Condition: Press: 760 Torr|
|Melting Point||237-240 °C | Condition: Solv: methanol (67-56-1); water (7732-18-5)|
|Density||1.401±0.06 g/cm3 | Condition: Temp: 20 °C Press: 760 Torr|
Naxifylline, a xanthine derivative, has been found to be an adenosine A1 receptor antagonist as well as diuretic agent that was once studied in heart failure an...
CVT5440 is a selective, high affinity A(2B) adenosine receptor antagonist. It may has the potential treatment of asthma and has good selectivity.
CF101 is a specific agonist to the A3 adenosine receptor, which inhibits the development of colon carcinoma growth in cell cultures and xenograft murine models...
Valsartan is a selective angiotensin II receptor antagonist, used to treat high blood pressure and congestive heart failure.
CGS 21680 Hydrochloride
CGS 21680 Hcl is an adenosine A2 receptor agonist with IC50 of 22 nM, exhibits 140-fold over A1 receptor.
An orally administered, potent and selective inhibitor of the adenosine 2a (A2a) receptor
N-0861 racemate is the racemate of N-0861 which appears to be an effective and selective A1 adenosine receptor antagonist in humans.
N-[(4-Aminophenyl)methyl]adenosine is a adenosine receptor inhibitor with Ki value of 29 nM for Rat ecto-5′-Nucleotidase.
KF21213 is a highly selective ligand for mapping CNS adenosine A2A receptors. The Ki values of KF21213 were 3.0 nM for the adenosine A2A receptors and >10,000 n...
Regadenoson, as a coronary vasodilator it is a selective A2A adenosine receptor agonist in myocardial imaging.
Neladenoson dalanate is a potent adenosine A1 receptor agonist originated by Bayer HealthCare Pharmaceuticals. It is applicated for the treatment of Chronic hea...
Preladenant is a potent as Adenosine A2 receptor antagonists.
Non-specific inhibitor of cAMP and cGMP phosphodiesterases. The increase in cAMP level as a result of phosphodiesterase inhibition by IBMX activates PKA leading...
Ticlopidine HCl is an P2 receptor inhibitor against ADP-induced platelet aggregation with IC50 of ~2 μM.
Potent, highly irreversible selective A2A antagonist
LUF6000 is an allosteric modulator of the human A3 adenosine receptor (AR). It was found to be an allosteric enhancer of Emax. It exerted an Emax-enhancing effe...
Sonedenoson is an adenosine A2 receptor agonist under the development of King Pharmaceuticals Research and Development. It can effectively promote rapid wound h...
Potent, highly selective A2A antagonist
Theophylline is a methylated xanthine derivative; that functions as a nonselective PDE4 inhibitor and nonselective adenosine receptor antagonist.
UP202-56, an adenosine analogue, selectively acts via A1 receptors to significantly decrease noxiously-evoked spinal c-Fos protein expression.