Lubiprostone - CAS 333963-40-9
Category: APIs
Molecular Formula:
C20H32F2O5
Molecular Weight:
390.46
COA:
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Description:
Lubiprostone, also known as RU-0211, is a new agent indicated for the treatment of patients with chronic constipation. It is a member of a new class of compounds called prostones. It was initially approved by the U.S. Food and Drug Administration (FDA) in 2006. Nonclinical studies demonstrated that lubiprostone exerts its effects on type-2 chloride channels (ClC-2), enhancing fluid secretion into the intestinal lumen.
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Related CAS:
136790-76-6 (open ring)
Appearance:
Solid powder
Synonyms:
7-[(1R,3R,6R,7R)-3-(1,1-Difluoropentyl)-3-hydroxy-8-oxo-2-oxabicyclo[4.3.0]non-7-yl]heptanoic acid; RU-0211; RU 0211; RU0211; Spi 0211; Spi-0211; Spi0211; Lubiprostone hemiketal; Lubiprostone. trade name Amitiza.
Storage:
Store in a cool and dry place (or refer to the Certificate of Analysis).
MSDS:
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Boiling Point:
532.3±50.0 °C at 760 Torr
Density:
1.175±0.06 g/cm3
InChIKey:
WGFOBBZOWHGYQH-MXHNKVEKSA-N
InChI:
1S/C20H32F2O5/c1-2-3-11-19(21,22)20(26)12-10-15-14(16(23)13-17(15)27-20)8-6-4-5-7-9-18(24)25/h14-15,17,26H,2-13H2,1H3,(H,24,25)/t14-,15-,17-,20-/m1/s1
Canonical SMILES:
O=C(O)CCCCCC[C@@H]1[C@@]2([H])CC[C@](O)(C(F)(F)CCCC)O[C@]2([H])CC1=O
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CAS 333963-40-9 Lubiprostone

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