|Description||LTURM34, with antiproliferative activity of a wide range of tumor cell lines in vitro, is a potent and selective DNA-PK inhibitor (IC50= 0.034 μM) with excellent selectivity over the Class I PI3K isoforms.|
|Brife Description||A specific DNA-P Kinhibitor (IC50= 0.034 μM)|
|Synonyms||8-dibenzothiophen-4-yl-2-morpholin-4-yl-1,3-benzoxazin-4-one; CHEMBL3764883; LTURM 34; BDBM50147675|
|Solubility||DMSO: ≥ 37.5 mg/mL|
|Storage||Store in a cool and dry place (or refer to the Certificate of Analysis).|
|Boiling Point||657.8±65.0 ℃ at 760 Torr|
The hydrochloride salt form of CC-115 which is a mTOR / DNA-PK inhibitor that probably has antineoplastic effect through influencing the cellular proliferation ...
PIK-75 is a p110α inhibitor with IC50 of 5.8 nM (200-fold more potently than p110β), isoform-specific mutants at Ser773, and also potently inhibits DNA-PK with ...
Compound 401, a pyrimido-isoquinolinone compound, is a selective and cell-permeable inhibitor that has an reversible function on DNA-dependent protein kinase (D...
LTURM34, with antiproliferative activity of a wide range of tumor cell lines in vitro, is a potent and selective DNA-PK inhibitor (IC50= 0.034 μM) with excellen...
CC-115, a DNA-PK and mTOR inhibitor, has been found to have probable anticarcinoma effect. IC50:13 nM and 21 nM for DNA-PK and mTOR respectively.