|Description||LPYFD-NH2, is a neuroprotective peptide that binds to Amyloid-β. In vitro and in vivo it protects neurons against toxic effects of Aβ (1-42), which can be used in treating Alzheimer's Disease.|
|Brife Description||A neuroprotective peptide that binds to myloid-β (Aβ)|
|Appearance||White lyophilised solid|
|Synonyms||H-Leu-Pro-Tyr-Phe-Asp-NH2; (3S)-4-amino-3-[[(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-amino-4-methylpentanoyl]pyrrolidine-2-carbonyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-phenylpropanoyl]amino]-4-oxobutanoic acid; ZINC98052568; AKOS024457970|
|Solubility||Soluble to 2 mg/ml in 10% acetonitrile/water|
|Storage||Store in a cool and dry place and at 0 - 4℃ for short term (days to weeks) or -39℃ for long term (months to years).|
|Melting Point||>185℃ (dec.)|
CGP 53353, also called DAPH 2, highly selectively inhibits procarcinogenic protein kinase C-βII (PKCβII) ,and it is also an inhibitor of prionogenic Sup35 fibr...
Amyloid β-peptide (42-1) (human)
Amyloid β-peptide (42-1) (human), is the predominant form of amyloid β-peptide found in the brains of patients with Alzheimer's disease.
Cryptotanshinone, a natural cell-permeable diterpene quinone isolated from Salvia miltiorrhiza, it inhibits acetylcholinesterase (IC50 = 4.09 μM) and reduces Aβ...
Colivelin, as a neuroprotective peptide and activator of STAT3 it is able to suppresses neuronal death. It is also able to protect neurons against the neurotoxi...
AC 186, also called GTPL8897, a diphenyl substituted cyclohexane derivatives, decreases Aβ levels in combination with ACP-105 in a rat model of Alzheimer's dise...
LPYFD-NH2, is a neuroprotective peptide that binds to Amyloid-β. In vitro and in vivo it protects neurons against toxic effects of Aβ (1-42), which can be used ...
SEN 1269, under the IUPAC name 3-[[5-[3-(dimethylamino)phenoxy]pyrimidin-2-yl]amino]phenol, is a derivative of pyrimidine that inhibits Amyloid-β (Aβ) aggregati...
K 114, like Congo Red (sc-359843) and BSB (sc-221384) it is a potent amyloid fibril-specific fluorescent dye (EC50 = 20 - 30 nM)
Tranilast, also called Rizaben or Tranilastum, has anti-inflammatory and immunomodulatory effect. It binds to Aβ40 monomers and increases Aβ40 fibrillation.
Compound W, also called 3,5-bis(4-Nitrophenoxy)benzoic acid, a 3,3'-diiodothyronine sulfate cross-reactive substance, is an inhibitor of γ-secretase which cause...
Tanshinone IIA, under the IUPAC name 1,6,6-trimethyl-8,9-dihydro-7H-naphtho[1,2-g]benzofuran-10,11-dione, one of the original anthracyclines isolated from Sa...
CGP 52411, also called DAPH, inhibits and reverses the formation of Aβ42 fibers (β-sheet content of aggregated β-amyloid (1-42): IC50 = 4.5 µM) in neurons assoc...
CRANAD 2, a difluoroboron-derivatized curcumins, is a near-infrared (NIR) Aβ plaque-specific fluorescent probe. It penetrates the blood-brain barrier and shows...
Y-29794 Tosylate, a novel orally non-peptide PPCE inhibitor, has shown to be able to prevent amyloid-like deposition in senescence-accelerated mice.Y-29794 exhi...
Dimebon dihydrochloride, also called Latrepirdine HCl, an orally-available non-selective antihistamine drug, it was explored the potention to treat Alzheimer's ...
ARN2966, also called 2-PMAP, as a Amyloid-β inhibitor, is non toxic, orally absorbable, blood-brain-barrier penetrable, and effective in vitro and in vivo.
FLI-06 , a Notch inhibitor that disrupts Notch trafficking and processing, disrupts the Golgi by mechanisms different from BFA or GCA. It Reduces amyloid β secr...
gamma-Secretase Modulators, as a potent modulator of γ-secretase, it is derived from oxadiazine. IC50: Aβ42=11 nM, Aβtotal/ Aβ42=1170.
Ro 90-7501, under the IUPCAS name 2-[2-(4-aminophenyl)-3H-benzimidazol-5-yl]-3H-benzimidazol-5-amine, a type of aminoquinolines, is an inhibitor of Aβ42 fibril ...
Frentizole, a nontoxic antiviral and immunosuppressive agent used clinically in rheumatoid arthritis and systemic lupus erythematosus, displayed a slightly impr...